| Tbio | Histone-lysine N-methyltransferase NSD3 |
Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.
This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015]
This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015]
Comments
| Disease | Target Count |
|---|---|
| Leukemia, Myelocytic, Acute | 120 |
| Disease | Target Count | P-value |
|---|---|---|
| juvenile dermatomyositis | 1187 | 5.4e-14 |
| non-small cell lung cancer | 2890 | 1.6e-08 |
| osteosarcoma | 7950 | 3.2e-07 |
| ovarian cancer | 8520 | 1.7e-06 |
| malignant mesothelioma | 3232 | 3.5e-06 |
| Pick disease | 1894 | 5.8e-06 |
| acute quadriplegic myopathy | 1158 | 1.6e-05 |
| psoriasis | 6694 | 8.9e-05 |
| medulloblastoma, large-cell | 6241 | 2.2e-04 |
| primitive neuroectodermal tumor | 3035 | 2.8e-04 |
| adult high grade glioma | 3801 | 1.0e-03 |
| glioblastoma | 5792 | 1.1e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 2.0e-03 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 3.3e-03 |
| atypical teratoid / rhabdoid tumor | 5112 | 5.3e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 9.1e-03 |
| group 3 medulloblastoma | 4104 | 1.9e-02 |
| Breast cancer | 3578 | 2.3e-02 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 2.8e-02 |
| spina bifida | 1074 | 3.5e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Wolf-Hirschhorn syndrome | 32 | 4.365 | 2.2 |
| Sotos syndrome | 13 | 4.006 | 2.0 |
| Disease | Target Count |
|---|---|
| Leukemia, Acute Myeloid | 17 |
| Disease | log2 FC | p |
|---|---|---|
| acute quadriplegic myopathy | 1.090 | 1.6e-05 |
| adult high grade glioma | -1.300 | 1.0e-03 |
| atypical teratoid / rhabdoid tumor | -1.100 | 5.3e-03 |
| Breast cancer | 3.300 | 2.3e-02 |
| glioblastoma | -1.300 | 1.1e-03 |
| group 3 medulloblastoma | 1.100 | 1.9e-02 |
| intraductal papillary-mucinous adenoma (... | 1.600 | 2.0e-03 |
| intraductal papillary-mucinous carcinoma... | 1.100 | 2.8e-02 |
| intraductal papillary-mucinous neoplasm ... | 1.800 | 9.1e-03 |
| juvenile dermatomyositis | 1.391 | 5.4e-14 |
| malignant mesothelioma | 1.300 | 3.5e-06 |
| medulloblastoma, large-cell | -1.200 | 2.2e-04 |
| non-small cell lung cancer | 1.009 | 1.6e-08 |
| osteosarcoma | -3.092 | 3.2e-07 |
| ovarian cancer | -2.000 | 1.7e-06 |
| pancreatic ductal adenocarcinoma liver m... | 1.849 | 3.3e-03 |
| Pick disease | 1.100 | 5.8e-06 |
| primitive neuroectodermal tumor | 1.300 | 2.8e-04 |
| psoriasis | -2.700 | 8.9e-05 |
| spina bifida | -1.308 | 3.5e-02 |
MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIAEDGGQTPYEATLQQGFQYPATTEDLPPLT 1 - 70 NGYPSSISVYETQTKYQSYNQYPNGSANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPSVP 71 - 140 QTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEVQASEHTKSKHESRKEKRKKSNKHDSSRSEE 141 - 210 RKSHKIPKLEPEEQNRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGT 211 - 280 YPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNH 281 - 350 SEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTR 351 - 420 RPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPASITMHKGSL 421 - 490 DLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVS 491 - 560 SPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPL 561 - 630 KKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKK 631 - 700 DTVCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGAC 701 - 770 GKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLV 771 - 840 SSYILICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAELMKLPMIPSS 841 - 910 SASKKKCEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICN 911 - 980 PRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQE 981 - 1050 LKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQ 1051 - 1120 YECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKR 1121 - 1190 AHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFN 1191 - 1260 YNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIKTEPKQMHEDYCFQCGDG 1261 - 1330 GELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALE 1331 - 1400 GRLCCSEHDPMAPVSPEYWSKIKCKWESQDHGEEVKE 1401 - 1437 //
