| Tbio | Histone-lysine N-methyltransferase NSD3 |
Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.
This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015]
This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015]
Comments
Property Summary
| NCBI Gene PubMed Count | 24 |
| Grant Count | 15 |
| R01 Count | 6 |
| Funding | $926,324.22 |
| PubMed Score | 15.45 |
| PubTator Score | 16.34 |
| Disease | log2 FC | p |
|---|---|---|
| malignant mesothelioma | 1.300 | 0.000 |
| psoriasis | -2.700 | 0.000 |
| osteosarcoma | -3.092 | 0.000 |
| atypical teratoid / rhabdoid tumor | -1.100 | 0.005 |
| glioblastoma | -1.300 | 0.001 |
| medulloblastoma, large-cell | -1.200 | 0.000 |
| primitive neuroectodermal tumor | 1.300 | 0.000 |
| juvenile dermatomyositis | 1.391 | 0.000 |
| acute quadriplegic myopathy | 1.090 | 0.000 |
| pancreatic ductal adenocarcinoma liver m... | 1.849 | 0.003 |
| non-small cell lung cancer | 1.009 | 0.000 |
| intraductal papillary-mucinous adenoma (... | 1.600 | 0.002 |
| intraductal papillary-mucinous carcinoma... | 1.100 | 0.028 |
| intraductal papillary-mucinous neoplasm ... | 1.800 | 0.009 |
| Breast cancer | 3.300 | 0.023 |
| adult high grade glioma | -1.300 | 0.001 |
| group 3 medulloblastoma | 1.100 | 0.019 |
| spina bifida | -1.435 | 0.033 |
| Pick disease | 1.100 | 0.000 |
| ovarian cancer | -2.100 | 0.000 |
| PMID | Text |
|---|---|
| 26626481 | Results demonstrate that the AML maintenance function of BRD4 requires its interaction with the short isoform of NSD3 lacking the methyltransferase domain. This protein is an adaptor that sustains leukemia by linking BRD4 to the CHD8 chromatin remodeler. |
| 25942451 | Studies indicate that the NSD methyltransferases NSD1, NSD2/WHSC1/MMSET and NSD3/WHSC1L1 were overexpressed, amplified or somatically mutated in multiple types of cancer, suggesting their critical role in cancer. |
| 25494638 | The results describe the binding of NSD1, 2 and 3 catalytic domains (CD) on histone tails through recognition of histone-lysine and methylation properties. |
| 24875858 | The involvement of the NSD3 methyltransferase as a component of the NUT fusion protein oncogenic complex identifies a new potential therapeutic target. |
| 24051013 | PPAPDC1B and WHSC1L1 played a major role in regulating the survival of breast cancer, pancreatic adenocarcinoma and small-cell lung cancer-derived cell lines. |
| 23269674 | methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NSD (nuclear receptor SET domain) family members in their histone H3 recognition |
| 23011637 | Data indicate that siRNA attenuated the expression levels of CCNG1 and NEK7, implying that WHSC1L1 appears to activate the expression of CCNG1 and NEK7 in cancer cells. |
| 21555454 | Functional studies with Brd4 indicate that the ET domain mediates pTEFb-independent transcriptional activation through a subset of these associated factors, including NSD3. |
| 20940404 | Overexpression of WHSC1L1 gene is associated with breast cancer. |
| 20599755 | NSD3L depletion increased the invasiveness of MDA-MB-231 breast cancer cells indicating that NSD3L normally restrain cellular metastatic potential. Together the presented data indicates that NSD3L is a candidate tumor suppressor. |
MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIAEDGGQTPYEATLQQGFQYPATTEDLPPLT 1 - 70 NGYPSSISVYETQTKYQSYNQYPNGSANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPSVP 71 - 140 QTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEVQASEHTKSKHESRKEKRKKSNKHDSSRSEE 141 - 210 RKSHKIPKLEPEEQNRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGT 211 - 280 YPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNH 281 - 350 SEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTR 351 - 420 RPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPASITMHKGSL 421 - 490 DLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVS 491 - 560 SPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPL 561 - 630 KKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKK 631 - 700 DTVCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGAC 701 - 770 GKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLV 771 - 840 SSYILICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAELMKLPMIPSS 841 - 910 SASKKKCEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICN 911 - 980 PRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQE 981 - 1050 LKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQ 1051 - 1120 YECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKR 1121 - 1190 AHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFN 1191 - 1260 YNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIKTEPKQMHEDYCFQCGDG 1261 - 1330 GELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALE 1331 - 1400 GRLCCSEHDPMAPVSPEYWSKIKCKWESQDHGEEVKE 1401 - 1437 //
| PMID | Year | Title |
|---|---|---|
| 26626481 | 2015 | NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler. |
| 25942451 | 2015 | The NSD family of protein methyltransferases in human cancer. |
| 25772364 | 2015 | SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage. |
| 25755297 | 2015 | System-wide Analysis of SUMOylation Dynamics in Response to Replication Stress Reveals Novel Small Ubiquitin-like Modified Target Proteins and Acceptor Lysines Relevant for Genome Stability. |
| 25640309 | 2015 | Systematic identification of molecular links between core and candidate genes in breast cancer. |
| 25494638 | 2014 | In vitro histone lysine methylation by NSD1, NSD2/MMSET/WHSC1 and NSD3/WHSC1L. |
| 25416956 | 2014 | A proteome-scale map of the human interactome network. |
| 25218447 | 2014 | Uncovering global SUMOylation signaling networks in a site-specific manner. |
| 24875858 | 2014 | NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism. |
| 24051013 | 2013 | PPAPDC1B and WHSC1L1 are common drivers of the 8p11-12 amplicon, not only in breast tumors but also in pancreatic adenocarcinomas and lung tumors. |
| More... |
