| Tbio | Neurolysin, mitochondrial |
Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A.
This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.[provided by RefSeq, Jun 2010]
This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.[provided by RefSeq, Jun 2010]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 2.0e-25 |
| ulcerative colitis | 1819 | 3.0e-08 |
| ovarian cancer | 8520 | 7.6e-05 |
| osteosarcoma | 7950 | 1.5e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 4.0e-04 |
| tuberculosis | 2010 | 4.2e-04 |
| primitive neuroectodermal tumor | 3035 | 3.7e-03 |
| adrenocortical carcinoma | 1428 | 4.7e-03 |
| medulloblastoma, large-cell | 6241 | 1.3e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 1.5e-02 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 1.5e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical carcinoma | 1.169 | 4.7e-03 |
| intraductal papillary-mucinous adenoma (... | 1.200 | 4.0e-04 |
| intraductal papillary-mucinous neoplasm ... | 1.300 | 1.5e-02 |
| medulloblastoma, large-cell | 1.400 | 1.3e-02 |
| non-small cell lung cancer | 1.488 | 2.0e-25 |
| osteosarcoma | 1.540 | 1.5e-04 |
| ovarian cancer | 1.100 | 7.6e-05 |
| pancreatic ductal adenocarcinoma liver m... | -1.708 | 1.5e-02 |
| primitive neuroectodermal tumor | 1.200 | 3.7e-03 |
| tuberculosis | 1.400 | 4.2e-04 |
| ulcerative colitis | -2.400 | 3.0e-08 |
MIARCLLAVRSLRRVGGSRILLRMTLGREVMSPLQAMSSYTVAGRNVLRWDLSPEQIKTRTEELIVQTKQ 1 - 70 VYDAVGMLGIEEVTYENCLQALADVEVKYIVERTMLDFPQHVSSDKEVRAASTEADKRLSRFDIEMSMRG 71 - 140 DIFERIVHLQETCDLGKIKPEARRYLEKSIKMGKRNGLHLPEQVQNEIKSMKKRMSELCIDFNKNLNEDD 141 - 210 TFLVFSKAELGALPDDFIDSLEKTDDDKYKITLKYPHYFPVMKKCCIPETRRRMEMAFNTRCKEENTIIL 211 - 280 QQLLPLRTKVAKLLGYSTHADFVLEMNTAKSTSRVTAFLDDLSQKLKPLGEAEREFILNLKKKECKDRGF 281 - 350 EYDGKINAWDLYYYMTQTEELKYSIDQEFLKEYFPIEVVTEGLLNTYQELLGLSFEQMTDAHVWNKSVTL 351 - 420 YTVKDKATGEVLGQFYLDLYPREGKYNHAACFGLQPGCLLPDGSRMMAVAALVVNFSQPVAGRPSLLRHD 421 - 490 EVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWDVDSLRRLSKHYKDGSPIADDLL 491 - 560 EKLVASRLVNTGLLTLRQIVLSKVDQSLHTNTSLDAASEYAKYCSEILGVAATPGTNMPATFGHLAGGYD 561 - 630 GQYYGYLWSEVFSMDMFYSCFKKEGIMNPEVGMKYRNLILKPGGSLDGMDMLHNFLKREPNQKAFLMSRG 631 - 700 LHAP 701 - 704 //
