| Tbio | Neurolysin, mitochondrial |
Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A.
This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.[provided by RefSeq, Jun 2010]
This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.[provided by RefSeq, Jun 2010]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2798 | 2.04927814807643E-25 |
| ulcerative colitis | 2087 | 2.98697335759821E-8 |
| ovarian cancer | 8492 | 7.5902066061353E-5 |
| osteosarcoma | 7933 | 1.52764273917709E-4 |
| intraductal papillary-mucinous adenoma (IPMA) | 2956 | 3.98240506683074E-4 |
| tuberculosis | 1563 | 4.18749595272208E-4 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3289 | 0.00186448628177577 |
| medulloblastoma, large-cell | 6234 | 0.00328955756972876 |
| primitive neuroectodermal tumor | 3031 | 0.00370735523075221 |
| adrenocortical carcinoma | 1427 | 0.00465845469045698 |
| pancreatic ductal adenocarcinoma liver metastasis | 1795 | 0.0152196522973714 |
| Disease | log2 FC | p |
|---|---|---|
| osteosarcoma | 1.540 | 0.000 |
| medulloblastoma, large-cell | 1.500 | 0.003 |
| primitive neuroectodermal tumor | 1.200 | 0.004 |
| adrenocortical carcinoma | 1.169 | 0.005 |
| pancreatic ductal adenocarcinoma liver m... | -1.708 | 0.015 |
| tuberculosis | 1.400 | 0.000 |
| non-small cell lung cancer | 1.488 | 0.000 |
| intraductal papillary-mucinous adenoma (... | 1.200 | 0.000 |
| intraductal papillary-mucinous neoplasm ... | 1.600 | 0.002 |
| ulcerative colitis | -2.400 | 0.000 |
| ovarian cancer | 1.100 | 0.000 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Cow | OMA Inparanoid |
| Opossum | OMA Inparanoid |
| Chicken | OMA EggNOG Inparanoid |
| Anole lizard | OMA EggNOG Inparanoid |
| Xenopus | OMA EggNOG Inparanoid |
| S.cerevisiae | OMA EggNOG Inparanoid |
| PMID | Text |
|---|---|
| 23383108 | A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of neurolysin (NLN) in peptide-treated PBMCs |
| 20877624 | Observational study of gene-disease association. (HuGE Navigator) |
| 20379614 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17251185 | Mutations at only two residues (Arg-470 and Arg-498) are required to swap specificity with thimet oligopeptidase, a result that is confirmed by testing the two-mutant constructs. |
MIARCLLAVRSLRRVGGSRILLRMTLGREVMSPLQAMSSYTVAGRNVLRWDLSPEQIKTRTEELIVQTKQ 1 - 70 VYDAVGMLGIEEVTYENCLQALADVEVKYIVERTMLDFPQHVSSDKEVRAASTEADKRLSRFDIEMSMRG 71 - 140 DIFERIVHLQETCDLGKIKPEARRYLEKSIKMGKRNGLHLPEQVQNEIKSMKKRMSELCIDFNKNLNEDD 141 - 210 TFLVFSKAELGALPDDFIDSLEKTDDDKYKITLKYPHYFPVMKKCCIPETRRRMEMAFNTRCKEENTIIL 211 - 280 QQLLPLRTKVAKLLGYSTHADFVLEMNTAKSTSRVTAFLDDLSQKLKPLGEAEREFILNLKKKECKDRGF 281 - 350 EYDGKINAWDLYYYMTQTEELKYSIDQEFLKEYFPIEVVTEGLLNTYQELLGLSFEQMTDAHVWNKSVTL 351 - 420 YTVKDKATGEVLGQFYLDLYPREGKYNHAACFGLQPGCLLPDGSRMMAVAALVVNFSQPVAGRPSLLRHD 421 - 490 EVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWDVDSLRRLSKHYKDGSPIADDLL 491 - 560 EKLVASRLVNTGLLTLRQIVLSKVDQSLHTNTSLDAASEYAKYCSEILGVAATPGTNMPATFGHLAGGYD 561 - 630 GQYYGYLWSEVFSMDMFYSCFKKEGIMNPEVGMKYRNLILKPGGSLDGMDMLHNFLKREPNQKAFLMSRG 631 - 700 LHAP 701 - 704 //
| PMID | Year | Title |
|---|---|---|
| 25944712 | 2015 | N-terminome analysis of the human mitochondrial proteome. |
| 25367360 | 2015 | Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium. |
| 24275569 | 2014 | An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
| 21269460 | 2011 | Initial characterization of the human central proteome. |
| 20877624 | 2010 | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. |
| 20379614 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | |
| 20068231 | 2010 | Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. |
| 19608861 | 2009 | Lysine acetylation targets protein complexes and co-regulates major cellular functions. |
| 18669648 | 2008 | A quantitative atlas of mitotic phosphorylation. |
| More... |
