Property Summary

NCBI Gene PubMed Count 11
PubMed Score 15.52
PubTator Score 6.53

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count P-value
ovarian cancer 8492 1.9158980220546E-8
intraductal papillary-mucinous adenoma (IPMA) 2956 1.39122910304382E-5
interstitial cystitis 2299 1.59141964928916E-5
intraductal papillary-mucinous carcinoma (IPMC) 2988 1.75819948929773E-4
psoriasis 6685 8.57501602742237E-4
lung cancer 4473 0.00121855371337488
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00318739716060407
ductal carcinoma in situ 1745 0.00630062658560871
invasive ductal carcinoma 2950 0.0239716211246999
Disease Target Count Z-score Confidence
Posterior polymorphous corneal dystrophy 24 5.701 2.9
Pilomatrixoma 11 3.444 1.7

Expression

Synonym

Accession Q9BRP0 Q5T8B4 Q9BX22 Q9HA54 Q9Y4M0 hOvo2
Symbols PPCD1
ZNF339
EUROIMAGE566589

Gene

  Ortholog (11)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG
Cow OMA EggNOG Inparanoid
Opossum EggNOG Inparanoid
Platypus EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Anole lizard EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid

 GO Component (1)

Gene RIF (5)

PMID Text
26873447 that the OVOL1-OVOL2 axis may actively contribute to cell differentiation and proliferation in the hair bulb
26749309 data demonstrate that all four mutated OVOL2 promoters exhibited more transcriptional activity than the corresponding wild-type promoter
26619963 OVOL2 is a colorectal tumor suppressor that blocks WNT signaling by facilitating the recruitment of histone deacetylase 1 to the TCF4-beta-catenin complex.
22737237 Molecular phylogeny of OVOL1, OVOL2 and OVOL3 genes illustrates a conserved C2H2 zinc finger domain coupled by hypervariable unstructured regions in humans and other species
19700410 Ovol2 directly represses two critical downstream targets, c-Myc and Notch1, thereby suppressing keratinocyte transient proliferation and terminal differentiation, respectively

AA Sequence

MPKVFLVKRRSLGVSVRSWDELPDEKRADTYIPVGLGRLLHDPPEDCRSDGGSSSGSGSSSAGEPGGAES      1 - 70
SSSPHAPESETPEPGDAEGPDGHLATKQRPVARSKIKFTTGTCSDSVVHSCDLCGKGFRLQRMLNRHLKC     71 - 140
HNQVKRHLCTFCGKGFNDTFDLKRHVRTHTGIRPYKCNVCNKAFTQRCSLESHLKKIHGVQQQYAYKQRR    141 - 210
DKLYVCEDCGYTGPTQEDLYLHVNSAHPGSSFLKKTSKKLAALLQGKLTSAHQENTSLSEEEERK         211 - 275
//

Text Mined References (12)

PMID Year Title
26873447 2016 Activation of the OVOL1-OVOL2 Axis in the Hair Bulb and in Pilomatricoma.
26749309 2016 Autosomal-Dominant Corneal Endothelial Dystrophies CHED1 and PPCD1 Are Allelic Disorders Caused by Non-coding Mutations in the Promoter of OVOL2.
26619963 2016 OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and Is Down-regulated in Human Colorectal Tumors.
24124593 2013 Transcription factors OVOL1 and OVOL2 induce the mesenchymal to epithelial transition in human cancer.
22737237 2012 Molecular phylogeny of OVOL genes illustrates a conserved C2H2 zinc finger domain coupled by hypervariable unstructured regions.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
19700410 2009 Ovol2 suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing c-Myc and Notch1.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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