| Tdark | Neuralized-like protein 2 |
Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity).
This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]
This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Comments
Property Summary
| NCBI Gene PubMed Count | 9 |
| Grant Count | 5 |
| R01 Count | 5 |
| Funding | $194,055.51 |
| PubMed Score | 3.16 |
| PubTator Score | 2.45 |
MAAASEPVDSGALWGLERPEPPPTRFHRVHGANIRVDPSGTRATRVESFAHGVCFSREPLAPGQVFLVEI 1 - 70 EEKELGWCGHLRLGLTALDPASLAPVPEFSLPDLVNLGHTWVFAITRHHNRVPREGRPEAEAAAPSRPPT 71 - 140 LLVEPYLRIEQFRIPRDRLVGRSRPGLYSHLLDQLYELNVLPPTARRSRLGVLFCPRPDGTADMHIIING 141 - 210 EDMGPSARGLPAAQPLYAVVDVFASTKSVRLVQLEYGLPSLQTLCRLVIQRSMVHRLAIDGLHLPKELKD 211 - 280 FCKYE 281 - 285 //
| PMID | Year | Title |
|---|---|---|
| 19723503 | 2009 | Neuralized-2: expression in human and rodents and interaction with Delta-like ligands. |
| 19472918 | 2008 | Candidate-gene testing for orphan limb-girdle muscular dystrophies. |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| 14992713 | 2004 | Ozz; a new name on the long list of beta-catenin's nemeses. |
| 14960280 | 2004 | Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis. |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
| 12076535 | 2002 | The SOCS box: a tale of destruction and degradation. |
| 11780052 | 2001 | The DNA sequence and comparative analysis of human chromosome 20. |
