1. Home
  2. Targets
  3. Neuralized-like protein 2

Tdark Neuralized-like protein 2

Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity).

This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]

 Comments

Property Summary

NCBI Gene PubMed Count 9
PubMed Score 3.16
PubTator Score 2.45

Knowledge Summary

Patent

No data available

Expression

Synonym

Accession Q9BR09 Q3KR34
Symbols OZZ
OZZ-E3
C20orf163

Gene

NEURL2

  Ortholog (12)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG
Opossum EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA EggNOG

 GO Component (1)

 GO Process (2)

 Compartment GO Term (7)

 IMPC Term (3)

 MGI Term (4)

 HCA RNA Cell Line (56)

See all...

Pathway (3)

 UniProt Keyword (5)

Gene RIF (1)

PMID Text
19472918 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence 

MAAASEPVDSGALWGLERPEPPPTRFHRVHGANIRVDPSGTRATRVESFAHGVCFSREPLAPGQVFLVEI      1 - 70
EEKELGWCGHLRLGLTALDPASLAPVPEFSLPDLVNLGHTWVFAITRHHNRVPREGRPEAEAAAPSRPPT     71 - 140
LLVEPYLRIEQFRIPRDRLVGRSRPGLYSHLLDQLYELNVLPPTARRSRLGVLFCPRPDGTADMHIIING    141 - 210
EDMGPSARGLPAAQPLYAVVDVFASTKSVRLVQLEYGLPSLQTLCRLVIQRSMVHRLAIDGLHLPKELKD    211 - 280
FCKYE                                                                     281 - 285
//

Text Mined References (9)

PMID Year Title
19723503 2009 Neuralized-2: expression in human and rodents and interaction with Delta-like ligands.
19472918 2008 Candidate-gene testing for orphan limb-girdle muscular dystrophies.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14992713 2004 Ozz; a new name on the long list of beta-catenin's nemeses.
14960280 2004 Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12076535 2002 The SOCS box: a tale of destruction and degradation.
11780052 2001 The DNA sequence and comparative analysis of human chromosome 20.