Property Summary

NCBI Gene PubMed Count 133
Grant Count 74
R01 Count 38
Funding $9,367,898.21
PubMed Score 239.38
PubTator Score 240.70

Knowledge Summary

Patent

No data available

Expression

Synonym

Accession Q99612 B2RE86 B4DDN0 D3DRR1 F5H3M5 Q5VUT7 Q5VUT8 Q9BT79
Symbols GBF
ZF9
BCD1
CBA1
CPBP
PAC1
ST12
COPEB

Gene

Gene RIF (123)

PMID Text
26193637 KLF6 overexpression partially phenocopied chaetocin treatment in DDLPS cells and induced phenotypic changes that were consistent with adipocytic differentiation, suggesting that the effects of increased H3K9me3 may be mediated through KLF6
25686501 Palmitic acid increases Ppargamma and Klf6 & Klf9 gene expression and promotes triglyceride accumulation in HepG2 cells.
25652467 In this review, we focus on the functions, roles, and regulatory networks of these five KLFs in HCC, summarize key pathways, and propose areas for further investigation
25537765 KLF6 is a novel regulator of human villous trophoblast fusion.
25230316 Study revealed that overexpression of miR-101 inhibited the proliferation, cell migration, invasion, and promoted apoptosis of glioblastoma stem cells by directly targeting KLF6
25182666 the possibility that overexpression of miR-181a contributes to the increased permeability of BTB by targeting KLF6, thereby revealing potential therapeutic targets for the treatment of brain gliomas.
24921656 Data show that MiR-1301 and miR-210 specifically target the tumor suppressive KLF6-FL isoform but not the oncogenic KLF6-SV1 isoform in hepatocellular carcinoma.
24634218 Data indicate that upon IL-1beta stimulation, Kruppel-like factor 6 (KLF6) was recruited to promoters of a subset of NF-kappaB target genes in a p65-dependent manner, which was in turn required for the optimal binding of p65 to the target gene promoters.
24519062 Downregulation of KLF6 during the progression of breast cancer is independent of the mutations and occurs by a different mechanism.
24385430 KLF6 is required for optimal LPS-induced pro-inflammatory gene expression, acting cooperatively with NF-kappaB
More...

AA Sequence

MDVLPMCSIFQELQIVHETGYFSALPSLEEYWQQTCLELERYLQSEPCYVSASEIKFDSQEDLWTKIILA      1 - 70
REKKEESELKISSSPPEDTLISPSFCYNLETNSLNSDVSSESSDSSEELSPTAKFTSDPIGEVLVSSGKL     71 - 140
SSSVTSTPPSSPELSREPSQLWGCVPGELPSPGKVRSGTSGKPGDKGNGDASPDGRRRVHRCHFNGCRKV    141 - 210
YTKSSHLKAHQRTHTGEKPYRCSWEGCEWRFARSDELTRHFRKHTGAKPFKCSHCDRCFSRSDHLALHMK    211 - 280
RHL                                                                       281 - 283
//

Text Mined References (134)

PMID Year Title
26193637 2015 Increased H3K9me3 drives dedifferentiated phenotype via KLF6 repression in liposarcoma.
25686501 2015 The activation of peroxisome proliferator-activated receptor ? is regulated by Krüppel-like transcription factors 6 & 9 under steatotic conditions.
25652467 2015 Krüppel-like factors in hepatocellular carcinoma.
25537765 2015 A novel regulator of human villous trophoblast fusion: the Krüppel-like factor 6.
25230316 2015 miR-101 acts as a tumor suppressor by targeting Kruppel-like factor 6 in glioblastoma stem cells.
25182666 2014 MiR-181a regulates blood-tumor barrier permeability by targeting Krüppel-like factor 6.
24921656 2014 Identification of miRNAs that specifically target tumor suppressive KLF6-FL rather than oncogenic KLF6-SV1 isoform.
24634218 2014 Krüppel-like factor 6 is a co-activator of NF-?B that mediates p65-dependent transcription of selected downstream genes.
24519062 2014 Mutations and Krüppel-like factor 6 (KLF6) expression levels in breast cancer.
24385430 2014 Kruppel-like transcription factor 6 regulates inflammatory macrophage polarization.
More...