Tdark ZSCAN10 Zinc finger and SCAN domain-containing protein 10

Protein Summary

Description

Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression of target genes, depending on the context. Specifically binds the 5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4.

Uniprot Accession IDs

• Q96SZ4
• B3KQD3
• H0YFS6
• Q1WWM2

Gene Name

• ZSCAN10

Ensembl ID

• ENST00000252463
• ENSP00000252463
• ENSG00000130182
• ENST00000538082
• ENSP00000440047
• ENST00000575108
• ENSP00000459520

Symbol

• ZNF206
• ZFP206
• ZNF206

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.77
protein domain	0.73
transcription factor binding site profile	0.67
PubMedID	0.6
transcription factor	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.81   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 26   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.81   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0