| Tdark | Copine-2 |
Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties.
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Sequence analysis identified multiple alternatively spliced transcript variants but their full-length natures could not be determined. [provided by RefSeq, Jul 2008]
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Sequence analysis identified multiple alternatively spliced transcript variants but their full-length natures could not be determined. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 4.3e-14 |
| Astrocytoma, Pilocytic | 3081 | 2.3e-10 |
| ovarian cancer | 8520 | 3.1e-07 |
| glioblastoma | 5792 | 1.9e-06 |
| ependymoma | 4679 | 1.1e-05 |
| pediatric high grade glioma | 1064 | 2.5e-05 |
| ulcerative colitis | 1819 | 3.7e-05 |
| primitive neuroectodermal tumor | 3035 | 4.6e-05 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 4.8e-04 |
| atypical teratoid / rhabdoid tumor | 5112 | 5.1e-04 |
| medulloblastoma, large-cell | 6241 | 4.8e-03 |
| gastric carcinoma | 807 | 3.0e-02 |
| oligodendroglioma | 2850 | 4.4e-02 |
| astrocytic glioma | 2597 | 4.8e-02 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | 1.200 | 4.8e-02 |
| Astrocytoma, Pilocytic | 1.700 | 2.3e-10 |
| atypical teratoid / rhabdoid tumor | 1.200 | 5.1e-04 |
| ependymoma | 1.100 | 1.1e-05 |
| gastric carcinoma | 1.300 | 3.0e-02 |
| glioblastoma | 1.200 | 1.9e-06 |
| intraductal papillary-mucinous adenoma (... | -1.100 | 4.8e-04 |
| lung carcinoma | -1.200 | 4.3e-14 |
| medulloblastoma, large-cell | -1.400 | 4.8e-03 |
| oligodendroglioma | 1.300 | 4.4e-02 |
| ovarian cancer | 2.100 | 3.1e-07 |
| pediatric high grade glioma | 1.200 | 2.5e-05 |
| primitive neuroectodermal tumor | 1.600 | 4.6e-05 |
| ulcerative colitis | -1.200 | 3.7e-05 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA | ||
| OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA |
MAHIPSGGAPAAGAAPMGPQYCVCKVELSVSGQNLLDRDVTSKSDPFCVLFTENNGRWIEYDRTETAINN 1 - 70 LNPAFSKKFVLDYHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKKITRPLLLLNDKPAG 71 - 140 KGLITIAAQELSDNRVITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTLDPVWKPF 141 - 210 TVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVSQMCEARDSVPLEFECINPKKQRKKKNYKNS 211 - 280 GIIILRSCKINRDYSFLDYILGGCQLMFTVGIDFTASNGNPLDPSSLHYINPMGTNEYLSAIWAVGQIIQ 281 - 350 DYDSDKMFPALGFGAQLPPDWKVSHEFAINFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHV 351 - 420 ARFAAQATQQRTATQYFILLIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDSRML 421 - 490 RSHTGEEAARDIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKHKNLPPTNSEPA 491 - 548 //
