| Tdark | Copine-2 |
Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties.
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Sequence analysis identified multiple alternatively spliced transcript variants but their full-length natures could not be determined. [provided by RefSeq, Jul 2008]
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Sequence analysis identified multiple alternatively spliced transcript variants but their full-length natures could not be determined. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2844 | 4.33477504470917E-14 |
| pilocytic astrocytoma | 3086 | 2.56750803505381E-10 |
| ovarian cancer | 8492 | 3.0602145741251E-7 |
| posterior fossa group B ependymoma | 1530 | 9.98136128739293E-7 |
| pediatric high grade glioma | 2712 | 2.45502902772927E-5 |
| ulcerative colitis | 2087 | 3.6833326256886E-5 |
| primitive neuroectodermal tumor | 3031 | 4.60197613780603E-5 |
| glioblastoma | 5572 | 1.77785925251279E-4 |
| intraductal papillary-mucinous adenoma (IPMA) | 2956 | 4.78719643782699E-4 |
| atypical teratoid / rhabdoid tumor | 4369 | 5.13615962571598E-4 |
| medulloblastoma, large-cell | 6234 | 0.00481593519610155 |
| gastric carcinoma | 832 | 0.0302056883816185 |
| oligodendroglioma | 2849 | 0.0437488517007659 |
| astrocytic glioma | 2241 | 0.0477013350074796 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | 1.200 | 0.048 |
| oligodendroglioma | 1.300 | 0.044 |
| posterior fossa group B ependymoma | 1.200 | 0.000 |
| glioblastoma | 1.300 | 0.000 |
| atypical teratoid / rhabdoid tumor | 1.200 | 0.001 |
| medulloblastoma, large-cell | -1.400 | 0.005 |
| primitive neuroectodermal tumor | 1.600 | 0.000 |
| intraductal papillary-mucinous adenoma (... | -1.100 | 0.000 |
| pediatric high grade glioma | 1.200 | 0.000 |
| pilocytic astrocytoma | 1.700 | 0.000 |
| lung carcinoma | -1.200 | 0.000 |
| gastric carcinoma | 1.300 | 0.030 |
| ulcerative colitis | -1.200 | 0.000 |
| ovarian cancer | 2.100 | 0.000 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG |
| Dog | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Opossum | EggNOG Inparanoid |
| Platypus | OMA EggNOG Inparanoid |
| Chicken | OMA Inparanoid |
| Anole lizard | OMA Inparanoid |
| Xenopus | OMA Inparanoid |
| PMID | Text |
|---|---|
| 20381070 | This protein has been found differentially expressed in the anterior cingulate cortex in women patients with schizophrenia. |
MAHIPSGGAPAAGAAPMGPQYCVCKVELSVSGQNLLDRDVTSKSDPFCVLFTENNGRWIEYDRTETAINN 1 - 70 LNPAFSKKFVLDYHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKKITRPLLLLNDKPAG 71 - 140 KGLITIAAQELSDNRVITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTLDPVWKPF 141 - 210 TVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVSQMCEARDSVPLEFECINPKKQRKKKNYKNS 211 - 280 GIIILRSCKINRDYSFLDYILGGCQLMFTVGIDFTASNGNPLDPSSLHYINPMGTNEYLSAIWAVGQIIQ 281 - 350 DYDSDKMFPALGFGAQLPPDWKVSHEFAINFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHV 351 - 420 ARFAAQATQQRTATQYFILLIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDSRML 421 - 490 RSHTGEEAARDIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKHKNLPPTNSEPA 491 - 548 //
| PMID | Year | Title |
|---|---|---|
| 25416956 | 2014 | A proteome-scale map of the human interactome network. |
| 23533145 | 2013 | In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. |
| 21269460 | 2011 | Initial characterization of the human central proteome. |
| 21044950 | 2011 | Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. |
| 20381070 | 2010 | Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia. |
| 17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. |
| 15616553 | 2004 | The sequence and analysis of duplication-rich human chromosome 16. |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| 15146197 | 2004 | Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
| More... |
