| Tbio | CAP-Gly domain-containing linker protein 3 |
Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes.
This gene encodes a member of the cytoplasmic linker protein 170 family. Members of this protein family contain a cytoskeleton-associated protein glycine-rich domain and mediate the interaction of microtubules with cellular organelles. The encoded protein plays a role in T cell apoptosis by facilitating the association of tubulin and the lipid raft ganglioside GD3. The encoded protein also functions as a scaffold protein mediating membrane localization of phosphorylated protein kinase B. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
This gene encodes a member of the cytoplasmic linker protein 170 family. Members of this protein family contain a cytoskeleton-associated protein glycine-rich domain and mediate the interaction of microtubules with cellular organelles. The encoded protein plays a role in T cell apoptosis by facilitating the association of tubulin and the lipid raft ganglioside GD3. The encoded protein also functions as a scaffold protein mediating membrane localization of phosphorylated protein kinase B. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 4.3e-29 |
| ependymoma | 4679 | 5.9e-12 |
| ovarian cancer | 8520 | 7.6e-11 |
| glioblastoma | 5792 | 2.7e-07 |
| atypical teratoid / rhabdoid tumor | 5112 | 4.2e-05 |
| group 3 medulloblastoma | 4104 | 4.4e-05 |
| adult high grade glioma | 3801 | 4.5e-05 |
| Pick disease | 1894 | 8.4e-05 |
| medulloblastoma, large-cell | 6241 | 3.5e-04 |
| psoriasis | 6694 | 4.0e-04 |
| colon cancer | 1478 | 3.9e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Gender identity disorder | 4 | 4.363 | 2.2 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.600 | 4.5e-05 |
| atypical teratoid / rhabdoid tumor | -1.200 | 4.2e-05 |
| colon cancer | -1.100 | 3.9e-03 |
| ependymoma | -1.500 | 5.9e-12 |
| glioblastoma | -1.500 | 2.7e-07 |
| group 3 medulloblastoma | -1.800 | 4.4e-05 |
| lung carcinoma | 1.400 | 4.3e-29 |
| medulloblastoma, large-cell | -2.400 | 3.5e-04 |
| ovarian cancer | -1.600 | 7.6e-11 |
| Pick disease | -1.400 | 8.4e-05 |
| psoriasis | -1.400 | 4.0e-04 |
| Species | Source | Disease |
|---|---|---|
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
MTKTDPAPMAPPPRGEEEEEEEEDEPVPEAPSPTQERRQKPVVHPSAPAPLPKDYAFTFFDPNDPACQEI 1 - 70 LFDPQTTIPELFAIVRQWVPQVQHKIDVIGNEILRRGCHVNDRDGLTDMTLLHYACKAGAHGVGDPAAAV 71 - 140 RLSQQLLALGADVTLRSRWTNMNALHYAAYFDVPDLVRVLLKGARPRVVNSTCSDFNHGSALHIAASSLC 141 - 210 LGAAKCLLEHGANPALRNRKGQVPAEVVPDPMDMSLDKAEAALVAKELRTLLEEAVPLSCALPKVTLPNY 211 - 280 DNVPGNLMLSALGLRLGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRYFICPPK 281 - 350 QGLFASVSKISKAVDAPPSSVTSTPRTPRMDFSRVTGKGRREHKGKKKTPSSPSLGSLQQRDGAKAEVGD 351 - 420 QVLVAGQKQGIVRFYGKTDFAPGYWYGIELDQPTGKHDGSVFGVRYFTCPPRHGVFAPASRIQRIGGSTD 421 - 490 SPGDSVGAKKVHQVTMTQPKRTFTTVRTPKDIASENSISRLLFCCWFPWMLRAEMQS 491 - 547 //
