Property Summary

NCBI Gene PubMed Count 16
PubMed Score 155.79
PubTator Score 175.26

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count P-value
juvenile dermatomyositis 1189 1.42347199110415E-10
pituitary cancer 1972 2.3959243153027E-9
malignant mesothelioma 3163 9.98993286081743E-9
pilocytic astrocytoma 3086 2.62378956621399E-7
osteosarcoma 7933 1.36871076617403E-5
ulcerative colitis 2087 2.39451279491145E-5
cutaneous lupus erythematosus 1056 4.8690701271902E-5
psoriasis 6685 1.35285582755124E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 1.9003772169241E-4
pancreatic cancer 2300 4.07074082210997E-4
pediatric high grade glioma 2712 4.46598637321452E-4
glioblastoma 5572 5.94785085738544E-4
primary Sjogren syndrome 789 0.00113989137496862
interstitial cystitis 2299 0.00116427995577279
lung cancer 4473 0.00259656155159786
cystic fibrosis 1670 0.00265227589301811
invasive ductal carcinoma 2950 0.00458571218329215
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00487587206443937
Endometriosis 535 0.00665278127062265
ovarian cancer 8492 0.0150253964212403
active Crohn's disease 918 0.0151655637749776
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0181845823106222
Multiple myeloma 1328 0.0253793931812491
dermatomyositis 967 0.0276100284443202
ductal carcinoma in situ 1745 0.0281172455114017
Multiple Sclerosis 498 0.0336717889138153
Disease Target Count Z-score Confidence
Connective tissue disease 59 0.0 1.0
Rheumatoid Arthritis 1171 0.0 1.0

Expression

Synonym

Accession Q96AZ6 O00441 O00586
Symbols CD25
HEM45

Gene

PDB

1WLJ  

  Ortholog (8)

Gene RIF (8)

PMID Text
26116899 HIV-1 Vpr upregulates the expression of ISG20 in human monocyte-derived dendritic cells
25170834 HIV-1 Vpr upregulates the expression of ISG20 in human monocyte-derived dendritic cells
23830076 The results suggest that hantavirus infection interferes with DAXX-mediated apoptosis, and expression of interferon-activated Sp100 and ISG-20 proteins may indicate intracellular intrinsic antiviral attempts.
22647704 HIV-1 Vpr upregulates the expression of ISG20 in human monocyte-derived dendritic cells
21036379 ISG20 inhibited infections by hepatitis C virus, bovine viral diarrhea virus and hepatitis A virus. Moreover, ISG20 demonstrated cell-type specific antiviral activity against yellow fever virus, a classical flavivirus.
18278447 ISG20 has a role in reducing the synthesis of HBV proteins
15527770 ISG20has distinctive residues, Met14 and Arg53, to accommodate hydrogen bonds with the 2'-OH group of the UMP ribose, and these residues may be responsible for the preference of ISG20 for RNA substrates
12539042 HIV-1 Vpr upregulates the expression of ISG20 in human monocyte-derived dendritic cells

AA Sequence

MAGSREVVAMDCEMVGLGPHRESGLARCSLVNVHGAVLYDKFIRPEGEITDYRTRVSGVTPQHMVGATPF      1 - 70
AVARLEILQLLKGKLVVGHDLKHDFQALKEDMSGYTIYDTSTDRLLWREAKLDHCRRVSLRVLSERLLHK     71 - 140
SIQNSLLGHSSVEDARATMELYQISQRIRARRGLPRLAVSD                                 141 - 181
//

Text Mined References (19)

PMID Year Title
23830076 2013 Death-domain associated protein-6 (DAXX) mediated apoptosis in hantavirus infection is counter-balanced by activation of interferon-stimulated nuclear transcription factors.
23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
21732829 2011 Wnt signaling and Dupuytren's disease.
21269460 2011 Initial characterization of the human central proteome.
21036379 2011 Antiviral activities of ISG20 in positive-strand RNA virus infections.
18278447 2008 Cloning, eukaryotic expression of human ISG20 and preliminary study on the effect of its anti-HBV.
17445960 ISG20, an actor of the innate immune response.
16514659 2006 The exonuclease ISG20 mainly localizes in the nucleolus and the Cajal (Coiled) bodies and is associated with nuclear SMN protein-containing complexes.
16033969 2005 Interferon-induced exonuclease ISG20 exhibits an antiviral activity against human immunodeficiency virus type 1.
15527770 2004 Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease.
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