| Tbio | Myeloid-derived growth factor |
Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).
The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was considered an interleukin. However, this activity has not been reproducible and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]
The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was considered an interleukin. However, this activity has not been reproducible and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 4.6e-05 |
| psoriasis | 6694 | 5.7e-05 |
| Multiple myeloma | 1332 | 1.5e-04 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 1.9e-03 |
| glioblastoma | 5792 | 6.0e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Seasonal affective disorder | 28 | 3.573 | 1.8 |
| Coronary artery disease | 268 | 3.479 | 1.7 |
| diabetes mellitus | 1728 | 3.049 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| glioblastoma | 1.100 | 6.0e-03 |
| Multiple myeloma | 2.044 | 1.5e-04 |
| ovarian cancer | 1.700 | 4.6e-05 |
| pancreatic ductal adenocarcinoma liver m... | -2.194 | 1.9e-03 |
| psoriasis | 1.500 | 5.7e-05 |
