Tbio | Myeloid-derived growth factor |
Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).
The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was considered an interleukin. However, this activity has not been reproducible and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]
The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was considered an interleukin. However, this activity has not been reproducible and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]
Comments
Disease | Target Count | P-value |
---|---|---|
ovarian cancer | 8492 | 4.62305064757956E-5 |
psoriasis | 6685 | 5.70727829814111E-5 |
Multiple myeloma | 1328 | 1.48147303956599E-4 |
pancreatic ductal adenocarcinoma liver metastasis | 1795 | 0.00185059111829318 |
glioblastoma | 5572 | 0.00535390546538759 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Seasonal affective disorder | 25 | 3.549 | 1.8 |
Coronary artery disease | 240 | 3.483 | 1.7 |
diabetes mellitus | 1663 | 3.056 | 1.5 |
Disease | log2 FC | p |
---|---|---|
Multiple myeloma | 2.044 | 0.000 |
psoriasis | 1.500 | 0.000 |
glioblastoma | 1.200 | 0.005 |
pancreatic ductal adenocarcinoma liver m... | -2.194 | 0.002 |
ovarian cancer | 1.700 | 0.000 |
PMID | Text |
---|---|
25581518 | Bone marrow-derived monocytes and macrophages produce this protein endogenously to protect and repair the heart after myocardial infarction. |
21128247 | Taken together, these data suggest that c19orf10 might be one of the growth factors and potential molecular targets activated in HCC. |
17362502 | we identified a novel protein, c19orf10 (chromosome 19 open reading frame 10), produced by fibroblast-like synoviocytes |
14641539 | Observational study of gene-disease association. (HuGE Navigator) |
PMID | Year | Title |
---|---|---|
25944712 | 2015 | N-terminome analysis of the human mitochondrial proteome. |
25581518 | 2015 | Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction. |
25416956 | 2014 | A proteome-scale map of the human interactome network. |
23376485 | 2013 | Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. |
21269460 | 2011 | Initial characterization of the human central proteome. |
21128247 | 2011 | Identification of a secretory protein c19orf10 activated in hepatocellular carcinoma. |
19892738 | 2009 | Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini. |
17362502 | 2007 | The identification and characterization of a novel protein, c19orf10, in the synovium. |
15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
15057824 | 2004 | The DNA sequence and biology of human chromosome 19. |
More... |