1. Home
  2. Targets
  3. Metallothionein-1L

Tbio Metallothionein-1L

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

 Comments

Property Summary

NCBI Gene PubMed Count 7
PubMed Score 40.10
PubTator Score 2.10

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
lung adenocarcinoma 2714 1.1018393926853E-4
inflammatory breast cancer 404 0.0143628206021807
facioscapulohumeral dystrophy 286 0.0187107989820797

Expression

  Differential Expression (3)

Disease log2 FC p
lung adenocarcinoma -1.300 0.000
inflammatory breast cancer -1.100 0.014
facioscapulohumeral dystrophy -2.100 0.019

Synonym

Accession Q93083 MT-1L
Symbols MT1
MTF
MT1R

Gene

MT1L

 GO Function (1)

 GO Component (3)

 GO Process (2)

 Compartment GO Term (13)

Pathway (2)

 UniProt Keyword (9)

Gene RIF (1)

PMID Text
15747776 Eight MT genes were up-regulated after treatment of T-ALL cells with 0.15 and 1.5 microg/mL of metal ores. Heavy metal binding activity.

AA Sequence 

MDPNCSCATGGSCSCASSCKCKECKCTSCKKSCCSCCPMGCAKCAQGCVCKGASEKCSCCA               1 - 61
//

Text Mined References (7)

PMID Year Title
16395595 2006 Human-specific nonsense mutations identified by genome sequence comparisons.
15747776 2003 Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
9074634 1997 Human metallothionein gene MT1L mRNA is present in several human tissues but is unlikely to produce a metallothionein protein.
8766831 1996 Cloning and sequencing a novel metallothionein I isoform expressed in human reticulocytes.
8049263 1994 Characterisation of six additional human metallothionein genes.
2286373 1990 Human metallothionein genes: structure of the functional locus at 16q13.