Tbio FGF13 Fibroblast growth factor 13

Protein Summary

Description

Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus. May regulate voltage-gated sodium channels transport and function. May also play a role in MAPK signaling. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked cognitive disability mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini. [provided by RefSeq, Nov 2008]

Uniprot Accession IDs

• Q92913
• B1AK18
• B7Z4M7
• B7Z8N0
• D3DWH4
• O95830
• Q9NZH9
• Q9NZI0
• FGF-13

Gene Name

• FGF13

Ensembl ID

• ENST00000305414
• ENSP00000303391
• ENSG00000129682
• ENST00000315930
• ENSP00000322390
• ENST00000436198
• ENSP00000396198
• ENST00000441825
• ENSP00000409276
• ENST00000626909
• ENSP00000487411

Symbol

• FHF2
• FGF2
• FHF2
• FHF-2
• FGF-13

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.94
PubMedID	0.87
transcription factor perturbation	0.84
small molecule perturbation	0.74
molecular function	0.73

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Fibroblast Growth Factor 13

DTO Classes

Protein / Signaling / Growth Factor / Fibroblast Growth Factor 13

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1452.78   (req: < 5)

Gene RIFs: 32   (req: <= 3)

Antibodies: 533   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1452.78   (req: >= 5)

Gene RIFs: 32   (req: > 3)

Antibodies: 533   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0