Property Summary

NCBI Gene PubMed Count 29
PubMed Score 56.47
PubTator Score 39.87

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (5)

Disease Target Count P-value
osteosarcoma 7933 6.98444796007562E-8
tuberculosis 1563 5.06529481978275E-6
psoriasis 6685 4.32165889326973E-5
intraductal papillary-mucinous adenoma (IPMA) 2956 3.83700601828054E-4
lung cancer 4473 8.09130674138107E-4
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00125430735032813
ovarian cancer 8492 0.00178449893893644
subependymal giant cell astrocytoma 2287 0.0398241586494829
Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0
Disease Target Count Z-score Confidence
Autistic Disorder 320 0.0 1.0
Disease Target Count Z-score Confidence
Spina bifida occulta 7 3.475 1.7

Expression

  Differential Expression (8)

Disease log2 FC p
psoriasis -1.800 0.000
osteosarcoma -2.488 0.000
tuberculosis -1.500 0.000
intraductal papillary-mucinous adenoma (... 1.500 0.000
intraductal papillary-mucinous carcinoma... 1.400 0.001
lung cancer 1.700 0.001
subependymal giant cell astrocytoma -1.448 0.040
ovarian cancer 1.200 0.002

Synonym

Accession Q92833 A8K9Z6 B7Z5S5 B7Z8L0 Q5U5L5 Q86X63
Symbols JMJ

Gene

PDB

5HYN  

  Ortholog (12)

Species Source
Chimp OMA EggNOG
Macaque OMA Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA Inparanoid

Gene RIF (20)

PMID Text
25939703 JARID2 inhibits leukemia cell proliferation by regulating CCND1 expression
25645357 Jarid2 is an important component of PRC2 that has a central role in coordinating hematopoietic stem and progenitor cell function
25620564 Results suggest a regulation loop where Jarid2 protein methylation fine-tunes polycomb repressive complex 2 (PRC2) activity depending on the chromatin context.
25542019 TGF-ss-dependent expression changes of EMT-related genes were inhibited by JARID2 knockdown and enhanced by JARID2 overexpression.
25155265 Data further strengthen the conclusion that JARID2 polymorphisms are associated with NSOC susceptibility.
24889693 Decreased miRNA-940 affects the proliferation and migration of the progenitor cells of the secondary heart field by targeting JARID2.
24856900 miR-155 regulates the fate of Th17 and Treg cells and miR-155 contributes to Th17 cell function by suppressing the inhibitory effects of Jarid2.
24462204 Jarid2 is an important mediator of Xist-induced PRC2 targeting.
24374312 The presence of long noncoding RNAs stimulated JARID2-EZH2 interactions in vitro and JARID2-mediated recruitment of PRC2 to chromatin.
23435416 The interaction of JARID2 at these promoters is dependent on EED.
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AA Sequence

MSKERPKRNIIQKKYDDSDGIPWSEERVVRKVLYLSLKEFKNSQKRQHAEGIAGSLKTVNGLLGNDQSKG      1 - 70
LGPASEQSENEKDDASQVSSTSNDVSSSDFEEGPSRKRPRLQAQRKFAQSQPNSPSTTPVKIVEPLLPPP     71 - 140
ATQISDLSKRKPKTEDFLTFLCLRGSPALPNSMVYFGSSQDEEEVEEEDDETEDVKTATNNASSSCQSTP    141 - 210
RKGKTHKHVHNGHVFNGSSRSTREKEPVQKHKSKEATPAKEKHSDHRADSRREQASANHPAAAPSTGSSA    211 - 280
KGLAATHHHPPLHRSAQDLRKQVSKVNGVTRMSSLGAGVTSAKKMREVRPSPSKTVKYTATVTKGAVTYT    281 - 350
KAKRELVKDTKPNHHKPSSAVNHTISGKTESSNAKTRKQVLSLGGASKSTGPAVNGLKVSGRLNPKSCTK    351 - 420
EVGGRQLREGLQLREGLRNSKRRLEEAHQAEKPQSPPKKMKGAAGPAEGPGKKAPAERGLLNGHVKKEVP    421 - 490
ERSLERNRPKRATAGKSTPGRQAHGKADSASCENRSTSQPESVHKPQDSGKAEKGGGKAGWAAMDEIPVL    491 - 560
RPSAKEFHDPLIYIESVRAQVEKFGMCRVIPPPDWRPECKLNDEMRFVTQIQHIHKLGRRWGPNVQRLAC    561 - 630
IKKHLKSQGITMDELPLIGGCELDLACFFRLINEMGGMQQVTDLKKWNKLADMLRIPRTAQDRLAKLQEA    631 - 700
YCQYLLSYDSLSPEEHRRLEKEVLMEKEILEKRKGPLEGHTENDHHKFHPLPRFEPKNGLIHGVAPRNGF    701 - 770
RSKLKEVGQAQLKTGRRRLFAQEKEVVKEEEEDKGVLNDFHKCIYKGRSVSLTTFYRTARNIMSMCFSKE    771 - 840
PAPAEIEQEYWRLVEEKDCHVAVHCGKVDTNTHGSGFPVGKSEPFSRHGWNLTVLPNNTGSILRHLGAVP    841 - 910
GVTIPWLNIGMVFSTSCWSRDQNHLPYIDYLHTGADCIWYCIPAEEENKLEDVVHTLLQANGTPGLQMLE    911 - 980
SNVMISPEVLCKEGIKVHRTVQQSGQFVVCFPGSFVSKVCCGYSVSETVHFATTQWTSMGFETAKEMKRR    981 - 1050
HIAKPFSMEKLLYQIAQAEAKKENGPTLSTISALLDELRDTELRQRRQLFEAGLHSSARYGSHDGSSTVA   1051 - 1120
DGKKKPRKWLQLETSERRCQICQHLCYLSMVVQENENVVFCLECALRHVEKQKSCRGLKLMYRYDEEQII   1121 - 1190
SLVNQICGKVSGKNGSIENCLSKPTPKRGPRKRATVDVPPSRLSASSSSKSASSSS                 1191 - 1246
//

Text Mined References (33)

PMID Year Title
25939703 2015 JARID2 inhibits leukemia cell proliferation by regulating CCND1 expression.
25645357 2015 Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2.
25620564 2015 Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation.
25542019 2014 JARID2 is involved in transforming growth factor-beta-induced epithelial-mesenchymal transition of lung and colon cancer cell lines.
25155265 2015 Association of JARID2 polymorphisms with non-syndromic orofacial clefts in northern Chinese Han population.
24889693 2014 miRNA-940 reduction contributes to human Tetralogy of Fallot development.
24856900 2014 miR-155 activates cytokine gene expression in Th17 cells by regulating the DNA-binding protein Jarid2 to relieve polycomb-mediated repression.
24462204 2014 Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome.
24374312 2014 Interactions between JARID2 and noncoding RNAs regulate PRC2 recruitment to chromatin.
23435416 2014 JARID2 is a direct target of the PAX3-FOXO1 fusion protein and inhibits myogenic differentiation of rhabdomyosarcoma cells.
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