Property Summary

NCBI Gene PubMed Count 30
PubMed Score 111.07
PubTator Score 41.46

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (4)

Disease Target Count P-value
atypical teratoid/rhabdoid tumor 1095 6.05978840320224E-11
juvenile dermatomyositis 1189 6.26595038751406E-10
glioblastoma 5572 6.67730317774005E-10
Duchenne muscular dystrophy 602 1.86150107096178E-9
pilocytic astrocytoma 3086 5.3414995975914E-9
pituitary cancer 1972 1.07945905829028E-8
malignant mesothelioma 3163 2.20950427317273E-7
sonic hedgehog group medulloblastoma 1482 2.93716043314422E-7
pediatric high grade glioma 2712 8.35624629983142E-7
posterior fossa group A ependymoma 1511 2.99586302508392E-6
ulcerative colitis 2087 7.04244401558746E-6
non-small cell lung cancer 2798 8.8378412191177E-6
ovarian cancer 8492 2.27455797137837E-5
interstitial cystitis 2299 3.88027791656215E-5
psoriasis 6685 3.57243336173627E-4
lung cancer 4473 5.47674304062944E-4
primitive neuroectodermal tumor 3031 7.95153488275508E-4
astrocytic glioma 2241 0.00310454504453264
oligodendroglioma 2849 0.00413131003066884
gastric carcinoma 832 0.00593013194422646
dermatomyositis 967 0.00683812568474219
primary pancreatic ductal adenocarcinoma 1271 0.0070610665080269
chronic kidney disease 90 0.0093225176291545
pancreatic cancer 2300 0.00943284466784715
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0139341277301856
esophageal adenocarcinoma 737 0.0179278454253891
Breast cancer 3099 0.0272509794404806
nasopharyngeal carcinoma 1056 0.0436018778682293
Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0
Disease Target Count
Anterior Segment Dysgenesis 7 2

Expression

Synonym

Accession Q92626 A8QM65 D6W4Y0 Q4KMG2
Symbols PXN
VPO
MG50
PRG2
COPOA
D2S448
D2S448E

Gene

PANTHER Protein Class (2)

  Ortholog (10)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Opossum EggNOG Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid

Gene RIF (17)

PMID Text
26178375 The catalytic domain of peroxidasin and its immunoglobulin (Ig) domains are required for efficient sulfilimine bond formation.
25713063 Despite sequence homology at the active site and biophysical properties similar to human peroxidases, the catalytic efficiency of bromide oxidation (kcat/KM(app)) of full-length hsPxd01 is rather low but increased upon truncation.
24939590 Novel mutations in PXDN cause microphthalmia and anterior segment dysgenesis
24895407 Peroxidasin is essential for eye development in the mouse.
24556843 MiR-4782-3p inhibited cell proliferation in NSCLC by targeting USP14, ZEB2 and XIAP.
22982576 studies demonstrate the enzymatic properties and substrate specificity of VPO1 are similar to MPO; however, significantly lower catalytic rate constants of VPO1 relative to MPO suggest the possibility of other physiologic roles for this peroxidase
22526679 VPO1 is likely to participate in host defense, with bactericidal activity mediated through the generation of HOCl.
22157634 Results from this study indicate that the 2p25.3 duplication disrupting PXDN and MYT1L is a potential autism-causing variant in the pedigree reported here and should receive further consideration as a candidate for autism
21907015 Homozygous mutations in PXDN cause congenital cataract, corneal opacity, and developmental glaucoma.
21820048 plays a critical role in ox-LDL-induced endothelial cell apoptosis
More...

AA Sequence

MAKRSRGPGRRCLLALVLFCAWGTLAVVAQKPGAGCPSRCLCFRTTVRCMHLLLEAVPAVAPQTSILDLR      1 - 70
FNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLY     71 - 140
LHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLKTY    141 - 210
AESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWL    211 - 280
RNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQN    281 - 350
TEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDS    351 - 420
VHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRIS    421 - 490
GVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNK    491 - 560
DGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIVE    561 - 630
AIATVDRAINSTRTHLFDSRPRSPNDLLALFRYPRDPYTVEQARAGEIFERTLQLIQEHVQHGLMVDLNG    631 - 700
TSYHYNDLVSPQYLNLIANLSGCTAHRRVNNCSDMCFHQKYRTHDGTCNNLQHPMWGASLTAFERLLKSV    701 - 770
YENGFNTPRGINPHRLYNGHALPMPRLVSTTLIGTETVTPDEQFTHMLMQWGQFLDHDLDSTVVALSQAR    771 - 840
FSDGQHCSNVCSNDPPCFSVMIPPNDSRARSGARCMFFVRSSPVCGSGMTSLLMNSVYPREQINQLTSYI    841 - 910
DASNVYGSTEHEARSIRDLASHRGLLRQGIVQRSGKPLLPFATGPPTECMRDENESPIPCFLAGDHRANE    911 - 980
QLGLTSMHTLWFREHNRIATELLKLNPHWDGDTIYYETRKIVGAEIQHITYQHWLPKILGEVGMRTLGEY    981 - 1050
HGYDPGINAGIFNAFATAAFRFGHTLVNPLLYRLDENFQPIAQDHLPLHKAFFSPFRIVNEGGIDPLLRG   1051 - 1120
LFGVAGKMRVPSQLLNTELTERLFSMAHTVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAHTFEDLKN   1121 - 1190
EIKNPEIREKLKRLYGSTLNIDLFPALVVEDLVPGSRLGPTLMCLLSTQFKRLRDGDRLWYENPGVFSPA   1191 - 1260
QLTQIKQTSLARILCDNADNITRVQSDVFRVAEFPHGYGSCDEIPRVDLRVWQDCCEDCRTRGQFNAFSY   1261 - 1330
HFRGRRSLEFSYQEDKPTKKTRPRKIPSVGRQGEHLSNSTSAFSTRSDASGTNDFREFVLEMQKTITDLR   1331 - 1400
TQIKKLESRLSTTECVDAGGESHANNTKWKKDACTICECKDGQVTCFVEACPPATCAVPVNIPGACCPVC   1401 - 1470
LQKRAEEKP                                                                1471 - 1479
//

Text Mined References (32)

PMID Year Title
26178375 2015 The Ancient Immunoglobulin Domains of Peroxidasin Are Required to Form Sulfilimine Cross-links in Collagen IV.
25713063 2015 Multidomain human peroxidasin 1 is a highly glycosylated and stable homotrimeric high spin ferric peroxidase.
24939590 2015 Novel mutations in PXDN cause microphthalmia and anterior segment dysgenesis.
24895407 2014 Peroxidasin is essential for eye development in the mouse.
24556843 2014 Activation of ?7 nicotinic acetylcholine receptor protects against oxidant stress damage through reducing vascular peroxidase-1 in a JNK signaling-dependent manner in endothelial cells.
23979707 2013 SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
22982576 2012 Vascular peroxidase 1 catalyzes the formation of hypohalous acids: characterization of its substrate specificity and enzymatic properties.
22842973 2012 Peroxidasin forms sulfilimine chemical bonds using hypohalous acids in tissue genesis.
22526679 2012 Microbicidal activity of vascular peroxidase 1 in human plasma via generation of hypochlorous acid.
More...