| Tbio | Zinc finger protein 516 |
Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress (PubMed:23446422).
Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc-finger protein, and belongs to the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. [provided by RefSeq, Sep 2012]
Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc-finger protein, and belongs to the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. [provided by RefSeq, Sep 2012]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| posterior fossa group A ependymoma | 468 | 3.4e-07 |
| malignant mesothelioma | 3232 | 2.4e-06 |
| cystic fibrosis | 1696 | 2.5e-04 |
| lung cancer | 4740 | 3.3e-04 |
| group 3 medulloblastoma | 4104 | 6.5e-04 |
| psoriasis | 6694 | 8.2e-04 |
| osteosarcoma | 7950 | 1.5e-03 |
| Breast cancer | 3578 | 2.5e-03 |
| primitive neuroectodermal tumor | 3035 | 4.7e-03 |
| Disease | log2 FC | p |
|---|---|---|
| Breast cancer | -1.700 | 2.5e-03 |
| cystic fibrosis | 1.348 | 2.5e-04 |
| group 3 medulloblastoma | -1.300 | 6.5e-04 |
| lung cancer | 1.200 | 3.3e-04 |
| malignant mesothelioma | -1.300 | 2.4e-06 |
| osteosarcoma | -2.135 | 1.5e-03 |
| posterior fossa group A ependymoma | 1.100 | 3.4e-07 |
| primitive neuroectodermal tumor | 1.200 | 4.7e-03 |
| psoriasis | -1.700 | 8.2e-04 |
MDRNREAEMELRRGPSPTRAGRGHEVDGDKATCHTCCICGKSFPFQSSLSQHMRKHTGEKPYKCPYCDHR 1 - 70 ASQKGNLKIHIRSHRTGTLIQGHEPEAGEAPLGEMRASEGLDACASPTKSASACNRLLNGASQADGARVL 71 - 140 NGASQADSGRVLLRSSKKGAEGSACAPGEAKAAVQCSFCKSQFERKKDLELHVHQAHKPFKCRLCSYATL 141 - 210 REESLLSHIERDHITAQGPGSGEACVENGKPELSPGEFPCEVCGQAFSQTWFLKAHMKKHRGSFDHGCHI 211 - 280 CGRRFKEPWFLKNHMKAHGPKTGSKNRPKSELDPIATINNVVQEEVIVAGLSLYEVCAKCGNLFTNLDSL 281 - 350 NAHNAIHRRVEASRTRAPAEEGAEGPSDTKQFFLQCLNLRPSAAGDSCPGTQAGRRVAELDPVNSYQAWQ 351 - 420 LATRGKVAEPAEYLKYGAWDEALAGDVAFDKDRREYVLVSQEKRKREQDAPAAQGPPRKRASGPGDPAPA 421 - 490 GHLDPRSAARPNRRAAATTGQGKSSECFECGKIFRTYHQMVLHSRVHRRARRERDSDGDRAARARCGSLS 491 - 560 EGDSASQPSSPGSACAAADSPGSGLADEAAEDSGEEGAPEPAPGGQPRRCCFSEEVTSTELSSGDQSHKM 561 - 630 GDNASERDTGESKAGIAASVSILENSSRETSRRQEQHRFSMDLKMPAFHPKQEVPVPGDGVEFPSSTGAE 631 - 700 GQTGHPAEKLSDLHNKEHSGGGKRALAPDLMPLDLSARSTRDDPSNKETASSLQAALVVHPCPYCSHKTY 701 - 770 YPEVLWMHKRIWHRVSCNSVAPPWIQPNGYKSIRSNLVFLSRSGRTGPPPALGGKECQPLLLARFTRTQV 771 - 840 PGGMPGSKSGSSPLGVVTKAASMPKNKESHSGGPCALWAPGPDGYRQTKPCHGQEPHGAATQGPLAKPRQ 841 - 910 EASSKPVPAPGGGGFSRSATPTPTVIARAGAQPSANSKPVEKFGVPPAGAGFAPTNKHSAPDSLKAKFSA 911 - 980 QPQGPPPAKGEGGAPPLPPREPPSKAAQELRTLATCAAGSRGDAALQAQPGVAGAPPVLHSIKQEPVAEG 981 - 1050 HEKRLDILNIFKTYIPKDFATLYQGWGVSGPGLEHRGTLRTQARPGEFVCIECGKSFHQPGHLRAHMRAH 1051 - 1120 SVVFESDGPRGSEVHTTSADAPKQGRDHSNTGTVQTVPLRKGT 1121 - 1163 //
