| Tbio | Zinc finger protein 516 |
Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress (PubMed:23446422).
Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc-finger protein, and belongs to the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. [provided by RefSeq, Sep 2012]
Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc-finger protein, and belongs to the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. [provided by RefSeq, Sep 2012]
Comments
| Disease | log2 FC | p |
|---|---|---|
| malignant mesothelioma | -1.300 | 0.000 |
| psoriasis | -1.700 | 0.001 |
| osteosarcoma | -2.135 | 0.002 |
| cystic fibrosis | 1.348 | 0.000 |
| primitive neuroectodermal tumor | 1.200 | 0.005 |
| lung cancer | 1.200 | 0.000 |
| group 3 medulloblastoma | -1.300 | 0.001 |
| posterior fossa group B ependymoma | 1.200 | 0.000 |
| Breast cancer | -1.700 | 0.003 |
| PMID | Text |
|---|---|
| 24241165 | ZNF516 promoter methylation was the best biomarker, with both sensitivity and specificity of 90% (AUC = 0.92), results subsequently corroborated in a Prevalence cohort. |
| 23045156 | one interacting gene pair (RBMS3 versus ZNF516) which, even after Bonferroni correction for multiple testing, showed consistently significant effects on hip bone mineral density. |
| 18976975 | Knockdown of zinc finger protein 516 (ZNF516) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells |
MDRNREAEMELRRGPSPTRAGRGHEVDGDKATCHTCCICGKSFPFQSSLSQHMRKHTGEKPYKCPYCDHR 1 - 70 ASQKGNLKIHIRSHRTGTLIQGHEPEAGEAPLGEMRASEGLDACASPTKSASACNRLLNGASQADGARVL 71 - 140 NGASQADSGRVLLRSSKKGAEGSACAPGEAKAAVQCSFCKSQFERKKDLELHVHQAHKPFKCRLCSYATL 141 - 210 REESLLSHIERDHITAQGPGSGEACVENGKPELSPGEFPCEVCGQAFSQTWFLKAHMKKHRGSFDHGCHI 211 - 280 CGRRFKEPWFLKNHMKAHGPKTGSKNRPKSELDPIATINNVVQEEVIVAGLSLYEVCAKCGNLFTNLDSL 281 - 350 NAHNAIHRRVEASRTRAPAEEGAEGPSDTKQFFLQCLNLRPSAAGDSCPGTQAGRRVAELDPVNSYQAWQ 351 - 420 LATRGKVAEPAEYLKYGAWDEALAGDVAFDKDRREYVLVSQEKRKREQDAPAAQGPPRKRASGPGDPAPA 421 - 490 GHLDPRSAARPNRRAAATTGQGKSSECFECGKIFRTYHQMVLHSRVHRRARRERDSDGDRAARARCGSLS 491 - 560 EGDSASQPSSPGSACAAADSPGSGLADEAAEDSGEEGAPEPAPGGQPRRCCFSEEVTSTELSSGDQSHKM 561 - 630 GDNASERDTGESKAGIAASVSILENSSRETSRRQEQHRFSMDLKMPAFHPKQEVPVPGDGVEFPSSTGAE 631 - 700 GQTGHPAEKLSDLHNKEHSGGGKRALAPDLMPLDLSARSTRDDPSNKETASSLQAALVVHPCPYCSHKTY 701 - 770 YPEVLWMHKRIWHRVSCNSVAPPWIQPNGYKSIRSNLVFLSRSGRTGPPPALGGKECQPLLLARFTRTQV 771 - 840 PGGMPGSKSGSSPLGVVTKAASMPKNKESHSGGPCALWAPGPDGYRQTKPCHGQEPHGAATQGPLAKPRQ 841 - 910 EASSKPVPAPGGGGFSRSATPTPTVIARAGAQPSANSKPVEKFGVPPAGAGFAPTNKHSAPDSLKAKFSA 911 - 980 QPQGPPPAKGEGGAPPLPPREPPSKAAQELRTLATCAAGSRGDAALQAQPGVAGAPPVLHSIKQEPVAEG 981 - 1050 HEKRLDILNIFKTYIPKDFATLYQGWGVSGPGLEHRGTLRTQARPGEFVCIECGKSFHQPGHLRAHMRAH 1051 - 1120 SVVFESDGPRGSEVHTTSADAPKQGRDHSNTGTVQTVPLRKGT 1121 - 1163 //
| PMID | Year | Title |
|---|---|---|
| 25578880 | 2015 | Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat. |
| 25378659 | 2015 | Genetic loci associated with circulating levels of very long-chain saturated fatty acids. |
| 24241165 | 2014 | Genome-wide methylation profiling reveals Zinc finger protein 516 (ZNF516) and FK-506-binding protein 6 (FKBP6) promoters frequently methylated in cervical neoplasia, associated with HPV status and ethnicity in a Chilean population. |
| 23446422 | 2013 | Replication stress links structural and numerical cancer chromosomal instability. |
| 23432519 | A genome-wide association study of recipient genotype and medium-term kidney allograft function. | |
| 23064961 | 2013 | GWAS of dental caries patterns in the permanent dentition. |
| 23045156 | 2013 | Gene-gene interaction between RBMS3 and ZNF516 influences bone mineral density. |
| 20834067 | 2010 | Joint influence of small-effect genetic variants on human longevity. |
| 19413330 | 2009 | Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. |
| 18029348 | 2008 | Toward a confocal subcellular atlas of the human proteome. |
| More... |
