Tbio | WD repeat-containing protein 20 |
This gene encodes a WD repeat-containing protein that functions to preserve and regulate the activity of the USP12-UAF1 deubiquitinating enzyme complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2011]
Comments
Disease | Target Count | P-value |
---|---|---|
Breast cancer | 3099 | 2.84881639970989E-26 |
osteosarcoma | 7933 | 3.23565145028092E-6 |
gastric cancer | 436 | 1.31399570359966E-4 |
medulloblastoma, large-cell | 6234 | 9.14085472275851E-4 |
ovarian cancer | 8492 | 0.00636013249814441 |
subependymal giant cell astrocytoma | 2287 | 0.010008120817866 |
Rheumatoid Arthritis | 1171 | 0.0146204511575966 |
group 3 medulloblastoma | 2254 | 0.0338979840486226 |
astrocytic glioma | 2241 | 0.0381016595154735 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
locked-in syndrome | 10 | 3.724 | 1.9 |
Hypertensive retinopathy | 9 | 3.331 | 1.7 |
Retinal artery occlusion | 1 | 3.003 | 1.5 |
Disease | log2 FC | p |
---|---|---|
Rheumatoid Arthritis | 1.400 | 0.015 |
gastric cancer | 1.100 | 0.000 |
astrocytic glioma | -1.300 | 0.038 |
osteosarcoma | -1.598 | 0.000 |
medulloblastoma, large-cell | -1.100 | 0.001 |
group 3 medulloblastoma | 1.100 | 0.034 |
subependymal giant cell astrocytoma | -1.591 | 0.010 |
Breast cancer | -1.700 | 0.000 |
ovarian cancer | 1.400 | 0.006 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG Inparanoid |
Mouse | OMA EggNOG |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Horse | OMA EggNOG |
Cow | OMA EggNOG Inparanoid |
Pig | OMA EggNOG |
Opossum | EggNOG Inparanoid |
Platypus | OMA EggNOG Inparanoid |
Chicken | OMA EggNOG Inparanoid |
Anole lizard | OMA EggNOG Inparanoid |
Xenopus | OMA EggNOG Inparanoid |
Zebrafish | OMA EggNOG |
Fruitfly | EggNOG Inparanoid |
PMID | Text |
---|---|
26790128 | our data suggest that downregulation of WDR20 due to 14q loss may be involved in the malignant transformation of ccRCCs, in part through activation of the ERK and protein kinase B/AKT pathways |
20628086 | Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
20147737 | WDR20 serves as a stimulatory subunit for preserving and regulating the activity of the subset of the UAF1 x USP12 complexes |
19913121 | Observational study of gene-disease association. (HuGE Navigator) |
MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSGNGDRLCFNVG 1 - 70 RELYFYIYKGVRKAADLSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLVGFSAGQVQLIDPIKKETSKL 71 - 140 FNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKSTR 141 - 210 NPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTG 211 - 280 GEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQS 281 - 350 RLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTT 351 - 420 PGNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRNHSMGHISSK 421 - 490 SSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLIFLEDCIVTACQEGFICTWGR 491 - 560 PGKVVSFNP 561 - 569 //
PMID | Year | Title |
---|---|---|
26790128 | 2016 | Downregulation of WDR20 due to loss of 14q is involved in the malignant transformation of clear cell renal cell carcinoma. |
25814554 | 2015 | Phospho-tyrosine dependent protein-protein interaction network. |
24275569 | 2014 | An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. |
23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
22814378 | 2012 | N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. |
21406692 | 2011 | System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. |
20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. |
20147737 | 2010 | WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex. |
20068231 | 2010 | Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. |
19913121 | 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. |
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