| Tbio | WD repeat-containing protein 20 |
Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336).
This gene encodes a WD repeat-containing protein that functions to preserve and regulate the activity of the USP12-UAF1 deubiquitinating enzyme complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2011]
This gene encodes a WD repeat-containing protein that functions to preserve and regulate the activity of the USP12-UAF1 deubiquitinating enzyme complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2011]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Thyroid cancer, papillary | 14 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| Breast cancer | 3578 | 2.8e-26 |
| ovarian cancer | 8520 | 5.1e-05 |
| gastric cancer | 459 | 1.3e-04 |
| osteosarcoma | 7950 | 2.8e-04 |
| medulloblastoma, large-cell | 6241 | 9.1e-04 |
| subependymal giant cell astrocytoma | 2287 | 1.0e-02 |
| Rheumatoid arthritis | 1191 | 1.5e-02 |
| group 3 medulloblastoma | 4104 | 3.4e-02 |
| astrocytic glioma | 2597 | 3.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| locked-in syndrome | 14 | 3.618 | 1.8 |
| Hypertensive Retinopathy | 14 | 3.303 | 1.7 |
| Brachial plexus neuropathy | 6 | 3.075 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | -1.300 | 3.8e-02 |
| Breast cancer | -1.700 | 2.8e-26 |
| gastric cancer | 1.100 | 1.3e-04 |
| group 3 medulloblastoma | 1.100 | 3.4e-02 |
| medulloblastoma, large-cell | -1.100 | 9.1e-04 |
| osteosarcoma | -1.388 | 2.8e-04 |
| ovarian cancer | -1.300 | 5.1e-05 |
| Rheumatoid arthritis | 1.400 | 1.5e-02 |
| subependymal giant cell astrocytoma | -1.591 | 1.0e-02 |
MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSGNGDRLCFNVG 1 - 70 RELYFYIYKGVRKAADLSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLVGFSAGQVQLIDPIKKETSKL 71 - 140 FNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKSTR 141 - 210 NPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTG 211 - 280 GEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQS 281 - 350 RLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTT 351 - 420 PGNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRNHSMGHISSK 421 - 490 SSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLIFLEDCIVTACQEGFICTWGR 491 - 560 PGKVVSFNP 561 - 569 //
