Property Summary

NCBI Gene PubMed Count 32
PubMed Score 42.88
PubTator Score 36.38

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (6)

Disease Target Count
Autistic Disorder 320
Disease Target Count P-value
non-small cell lung cancer 2798 6.47884237909269E-26
ovarian cancer 8492 1.47431375790575E-8
malignant mesothelioma 3163 2.04398080390611E-8
psoriasis 6685 6.95909219183816E-8
ulcerative colitis 2087 7.7300531271387E-8
ependymoma 2514 1.56108496554319E-7
cystic fibrosis 1670 4.91705221327852E-7
medulloblastoma, large-cell 6234 5.97952256112076E-7
atypical teratoid / rhabdoid tumor 4369 2.27816454892629E-6
tuberculosis and treatment for 6 months 686 3.83653145130516E-6
lung cancer 4473 1.0220378079948E-5
Breast cancer 3099 4.70255612843021E-5
glioblastoma 5572 1.30315163414754E-4
lung adenocarcinoma 2714 2.71200418644664E-4
nasopharyngeal carcinoma 1056 8.67499726257944E-4
primitive neuroectodermal tumor 3031 0.00101579675106164
pediatric high grade glioma 2712 0.00151036555641524
osteosarcoma 7933 0.00374222071436816
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0123388041192571
invasive ductal carcinoma 2950 0.0162314677361728
active Crohn's disease 918 0.0208035550946006
Gaucher disease type 3 76 0.0219631981175794
gastric carcinoma 832 0.0305134741141298
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0336518910163227
Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0
Disease Target Count Z-score Confidence
Acquired metabolic disease 267 0.0 2.0
Disease Target Count Z-score Confidence
Cancer 2346 0.0 4.0
Disease Target Count Z-score Confidence
Dyslexia 36 4.51 2.3
Intraductal papilloma 3 3.065 1.5

Expression

  Differential Expression (24)

Synonym

Accession Q8N1I0 O14584 O94824 Q8NB45
Symbols

Gene

  Ortholog (11)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Dog OMA Inparanoid
Cow OMA Inparanoid
Opossum OMA Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid
C. elegans OMA Inparanoid

Gene RIF (17)

PMID Text
26578796 These data identify DOCK4 as a putative 7q gene whose reduced expression can lead to erythroid dysplasia
26129894 DOCK4 signalling is necessary for lateral filopodial protrusions and tubule remodelling prior to vascular lumen formation
25644601 activator DOCK4 as a key component of the TGF-beta/Smad pathway that promotes lung ADC cell extravasation and metastasis.
24599690 The study found significant associations between autism and a SNP of the DOCK4 gene.
23720743 The Atypical guanine nucleotide exchange factor Dock4 regulates neurite differentiation through modulation of Rac1 GTPase and actin dynamics.
21682944 This study revealed ROCK4 as novel schizophrenia candidate genes in the Jewish population.
21532034 novel epigenetic alterations in myelodysplastic leukocytes and implicate DOCK4 as a pathogenic gene located on the 7q chromosomal region.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
20346443 Data suggest that exonic deletions of DOCK4 may act as a risk factor for reading impairment. Genomic disruption of both DOCK4 and CNTNAP5 genes may have an additive effect and may result in a more severe autism spectrum phenotype.
20346443 Observational study of gene-disease association. (HuGE Navigator)
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AA Sequence

MWIPTEHEKYGVVIASFRGTVPYGLSLEIGDTVQILEKCDGWYRGFALKNPNIKGIFPSSYVHLKNACVK      1 - 70
NKGQFEMVIPTEDSVITEMTSTLRDWGTMWKQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMK     71 - 140
DVKRHITARLDWGNEQLGLDLVPRKEYAMVDPEDISITELYRLMEHRHRKKDTPVQASSHHLFVQMKSLM    141 - 210
CSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLPKAPDKPERHCSLFVDLGSSELRKDIYITVHIIR    211 - 280
IGRMGAGEKKNACSVQYRRPFGCAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNL    281 - 350
TGSNAGLAVSLQLLHGDIEQIRREYSSVFSHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSV    351 - 420
ARNVEVTMFIVDSSGQTLKDFISFGSGEPPASEYHSFVLYHNNSPRWSELLKLPIPVDKFRGAHIRFEFR    421 - 490
HCSTKEKGEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKCEENTNLQDTTRYLKLPFSKGIFLGNNNQAM    491 - 560
KATKESFCITSFLCSTKLTQNGDMLDLLKWRTHPDKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDEN    561 - 630
SQKYGSKVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGALAYRDLIKVLKWYVDRITEAERQEHIQE    631 - 700
VLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSGALSQSQAVFLSSFPAV    701 - 770
YSELLKLFDVREVANLVQDTLGSLPTILHVDDSLQAIKLQCIGKTVESQLYTNPDSRYILLPVVLHHLHI    771 - 840
HLQEQKDLIMCARILSNVFCLIKKNSSEKSVLEEIDVIVASLLDILLRTILEITSRPQPSSSAMRFQFQD    841 - 910
VTGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLLQIFTVFRILIRPEMFPKDWTVMRLVANNVII    911 - 980
TTVLYLSDALRKNFLNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYGDMRVTMGCEIFS    981 - 1050
MWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMMDWEQRRSGNFKQVEAKLIDKLDSLMSE   1051 - 1120
GKGDETYRELFNSILLKKIERETWRESGVSLIATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYK   1121 - 1190
TELNKEEMYIRYIHKLYDLHLKAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTII   1191 - 1260
QNFDRGKCWENGIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFL   1261 - 1330
RNKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPESQEVLQREGV   1331 - 1400
PDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPGISRWFEVEKREVVEMSPLE   1401 - 1470
NAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDAAVNGGVSRYQEAFFVKEYILSHPEDGEKI   1471 - 1540
ARLRELMLEQAQILEFGLAVHEKFVPQDMRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSPRV   1541 - 1610
CRNSAPASVSPDGTRVIPRRSPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQPSPSTSSLS   1611 - 1680
STHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPCSAIYPTPVEPSQRMLFNHIGDGALPRS   1681 - 1750
DPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLISPPVPPRPTQTASPARHTTSVSPSPAGRSPLKGS   1751 - 1820
VQSFTPSPVEYHSPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAPLPVPVPVPVPSYGGE   1821 - 1890
EPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPVTSEPPALPPKPLAARSSHLENGARRTDPGPRPRPLP   1891 - 1960
RKVSQL                                                                   1961 - 1966
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Text Mined References (35)

PMID Year Title
26578796 2015 Reduced DOCK4 expression leads to erythroid dysplasia in myelodysplastic syndromes.
26129894 2015 A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis.
25644601 2015 TGF-?/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis.
24599690 2014 Family-based association study of ZNF533, DOCK4 and IMMP2L gene polymorphisms linked to autism in a northeastern Chinese Han population.
24324551 2013 Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23720743 2013 The atypical guanine nucleotide exchange factor Dock4 regulates neurite differentiation through modulation of Rac1 GTPase and actin dynamics.
22890011 2012 Genome-wide association study indicates variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrate.
22788528 2013 Genetic associations with C-reactive protein level and white blood cell count in the KARE study.
22747683 2012 Genetic variants associated with breast size also influence breast cancer risk.
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