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  4. Pleckstrin homology domain-containing family M member 2

Tbio Pleckstrin homology domain-containing family M member 2

May play a role in the regulation of conventional kinesin activity. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation (PubMed:15905402). May play a role in lysosomes movement and localization at the cell periphery (PubMed:25898167).

 Comments

Property Summary

NCBI Gene PubMed Count 7
PubMed Score 2.68
PubTator Score 19.92

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
posterior fossa group B ependymoma 1530 9.07142110938094E-12
psoriasis 6685 1.94662083138628E-5
medulloblastoma, large-cell 6234 4.56902486779871E-5
group 3 medulloblastoma 2254 8.12643335022834E-5
Disease Target Count Z-score Confidence
Left ventricular noncompaction 23 4.655 2.3

Expression

  Differential Expression (4)

Disease log2 FC p
psoriasis 2.500 0.000
group 3 medulloblastoma -1.300 0.000
medulloblastoma, large-cell -1.200 0.000
posterior fossa group B ependymoma -1.100 0.000

Synonym

Accession Q8IWE5 O94928 Q5VT65 Q6NUH9 Q7L8G1 Q8IVT7 Q8N2T4 Q96AY0 Q9NTF7 PH domain-containing family M member 2
Symbols SKIP

Gene

PLEKHM2

PANTHER Protein Class (1)

PDB

3CXB   3HW2   3ZFW  

  Ortholog (11)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG
Xenopus OMA EggNOG

 GO Function (1)

 GO Component (1)

 GO Process (4)

 Compartment GO Term (25)

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 IMPC Term (5)

 MGI Term (5)

 HCA RNA Cell Line (56)

See all...

Pathway (2)

 UniProt Keyword (7)

Gene RIF (3)

PMID Text
26464484 The association of PLEKHM2 mutation with dilated cardiomyopathy and left ventricular noncompaction supports the importance of autophagy for normal cardiac function.
19460752 Knockdown of pleckstrin homology domain containing, family M (with RUN domain) member 2 (PLEKHM2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells
15905402 A dynamic process of kinesin recruitment in Salmonella-infected cells is down-regulated by the SifA-mediated recruitment of SKIP on membranes [SKIP]

AA Sequence 

MEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDLSSGYWVLVVH      1 - 70
FTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFL     71 - 140
TLVSGLEFIRFELDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDS    141 - 210
AIAPSSEDYDFGDVFPAVPSVPSTDWEDGDLTDTVSGPRSTASDLTSSKASTRSPTQRQNPFNEEPAETV    211 - 280
SSSDTTPVHTTSQEKEEAQALDPPDACTELEVIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGD    281 - 350
GDSRNGSPSLGRDSPDTMLASPQEEGEGPSSTTESSERSEPGLLIPEMKDTSMERLGQPLSKVIDQLNGQ    351 - 420
LDPSTWCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGGGHHDPAGLGQP    421 - 490
LHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQLSLVREGPVSEPEPGTQEVLCQLKRDQPSP    491 - 560
CLSSAEDSGVDEGQGSPSEMVHSSEFRVDNNHLLLLMIHVFRENEEQLFKMIRMSTGHMEGNLQLLYVLL    561 - 630
TDCYVYLLRKGATEKPYLVEEAVSYNELDYVSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKS    631 - 700
AMIKGCREPPYPSILTDATMEKLALAKFVAQESKCEASAVTVRFYGLVHWEDPTDESLGPTPCHCSPPEG    701 - 770
TITKEGMLHYKAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCRRANTTDRPHA    771 - 840
FQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCCLVLTDDRLFTCHEDCQTSFF    841 - 910
RSLGTAKLGDISAVSTEPGKEYCVLEFSQDSQQLLPPWVIYLSCTSELDRLLSALNSGWKTIYQVDLPHT    911 - 980
AIQEASNKKKFEDALSLIHSAWQRSDSLCRGRASRDPWC                                   981 - 1019
//

Text Mined References (14)

PMID Year Title
26464484 2015 PLEKHM2 mutation leads to abnormal localization of lysosomes, impaired autophagy flux and associates with recessive dilated cardiomyopathy and left ventricular noncompaction.
25898167 2015 BORC, a multisubunit complex that regulates lysosome positioning.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
18996344 2008 Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation.
18787122 2008 The Salmonella virulence protein SifA is a G protein antagonist.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
18220336 2008 Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
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