Tbio | Pleckstrin homology domain-containing family M member 2 |
May play a role in the regulation of conventional kinesin activity. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation (PubMed:15905402). May play a role in lysosomes movement and localization at the cell periphery (PubMed:25898167).
Comments
Disease | Target Count | P-value |
---|---|---|
posterior fossa group B ependymoma | 1530 | 9.07142110938094E-12 |
psoriasis | 6685 | 1.94662083138628E-5 |
medulloblastoma, large-cell | 6234 | 4.56902486779871E-5 |
group 3 medulloblastoma | 2254 | 8.12643335022834E-5 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Left ventricular noncompaction | 23 | 4.655 | 2.3 |
Disease | log2 FC | p |
---|---|---|
psoriasis | 2.500 | 0.000 |
group 3 medulloblastoma | -1.300 | 0.000 |
medulloblastoma, large-cell | -1.200 | 0.000 |
posterior fossa group B ependymoma | -1.100 | 0.000 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG Inparanoid |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Opossum | OMA EggNOG Inparanoid |
Platypus | OMA EggNOG Inparanoid |
Chicken | OMA EggNOG Inparanoid |
Anole lizard | OMA EggNOG |
Xenopus | OMA EggNOG |
PMID | Text |
---|---|
26464484 | The association of PLEKHM2 mutation with dilated cardiomyopathy and left ventricular noncompaction supports the importance of autophagy for normal cardiac function. |
19460752 | Knockdown of pleckstrin homology domain containing, family M (with RUN domain) member 2 (PLEKHM2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells |
15905402 | A dynamic process of kinesin recruitment in Salmonella-infected cells is down-regulated by the SifA-mediated recruitment of SKIP on membranes [SKIP] |
MEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDLSSGYWVLVVH 1 - 70 FTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFL 71 - 140 TLVSGLEFIRFELDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDS 141 - 210 AIAPSSEDYDFGDVFPAVPSVPSTDWEDGDLTDTVSGPRSTASDLTSSKASTRSPTQRQNPFNEEPAETV 211 - 280 SSSDTTPVHTTSQEKEEAQALDPPDACTELEVIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGD 281 - 350 GDSRNGSPSLGRDSPDTMLASPQEEGEGPSSTTESSERSEPGLLIPEMKDTSMERLGQPLSKVIDQLNGQ 351 - 420 LDPSTWCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGGGHHDPAGLGQP 421 - 490 LHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQLSLVREGPVSEPEPGTQEVLCQLKRDQPSP 491 - 560 CLSSAEDSGVDEGQGSPSEMVHSSEFRVDNNHLLLLMIHVFRENEEQLFKMIRMSTGHMEGNLQLLYVLL 561 - 630 TDCYVYLLRKGATEKPYLVEEAVSYNELDYVSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKS 631 - 700 AMIKGCREPPYPSILTDATMEKLALAKFVAQESKCEASAVTVRFYGLVHWEDPTDESLGPTPCHCSPPEG 701 - 770 TITKEGMLHYKAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCRRANTTDRPHA 771 - 840 FQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCCLVLTDDRLFTCHEDCQTSFF 841 - 910 RSLGTAKLGDISAVSTEPGKEYCVLEFSQDSQQLLPPWVIYLSCTSELDRLLSALNSGWKTIYQVDLPHT 911 - 980 AIQEASNKKKFEDALSLIHSAWQRSDSLCRGRASRDPWC 981 - 1019 //
PMID | Year | Title |
---|---|---|
26464484 | 2015 | PLEKHM2 mutation leads to abnormal localization of lysosomes, impaired autophagy flux and associates with recessive dilated cardiomyopathy and left ventricular noncompaction. |
25898167 | 2015 | BORC, a multisubunit complex that regulates lysosome positioning. |
23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
22814378 | 2012 | N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. |
18996344 | 2008 | Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation. |
18787122 | 2008 | The Salmonella virulence protein SifA is a G protein antagonist. |
18669648 | 2008 | A quantitative atlas of mitotic phosphorylation. |
18220336 | 2008 | Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. |
17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. |
16710414 | 2006 | The DNA sequence and biological annotation of human chromosome 1. |
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