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Tbio
RIOX2
Ribosomal oxygenase 2

Protein Summary
Description
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles. MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333396
  • ENSP00000328251
  • ENSG00000170854
  • ENST00000360258
  • ENSP00000353395
  • ENST00000394198
  • ENSP00000377748
  • ENST00000514314
  • ENSP00000424955

Symbol
  • MDIG
  • MINA
  • MINA53
  • NO52
  • ROX
  • MDIG
  • MINA
  • NO52
  • JMJD10
  • MINA53
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.11   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 354   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.11   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 354   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0