Property Summary

NCBI Gene PubMed Count 16
Grant Count 17
R01 Count 15
Funding $2,276,980.35
PubMed Score 81.85
PubTator Score 23.20

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (3)

Disease log2 FC p
osteosarcoma -2.330 0.000
active Crohn's disease -4.085 0.001
ulcerative colitis -3.600 0.000

Gene RIF (12)

PMID Text
24703425 Hepatic OSTalpha-OSTbeta expression is induced by hypoxia.
22535958 Ostbeta is required for both proper trafficking of Ostalpha and formation of the functional transport unit, and identify specific residues of Ostbeta critical for these processes.
22404213 Knockdown of organic solute transporter alpha (OSTalpha) by siRNA enhances HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells
21691099 The present report summarizes the evidence for a pleiotropic role of Ostalpha-Ostbeta in different tissues.
18847488 human OSTalpha is a glycoprotein that requires interaction with OSTbeta to reach the plasma membrane. However, glycosylation of OSTalpha is not necessary for interaction with the beta subunit or for membrane localization .
18469300 The mRNA expression of OSTalpha-OSTbeta was significantly reduced (OSTalpha: 3.3-fold, P = 0.006; OSTbeta: 2.6-fold, P = 0.03) in normal-weight but not overweight gallstone carriers
17332473 Demonstrate association of OST-alpha and OST-beta to determine trafficking to plasma membrane and activity.
16423920 These results indicate that expression of Ostalpha and Ostbeta are highly regulated in response to cholestasis and that this response is dependent on the FXR bile acid receptor.
16317684 the selective localization of OSTalpha and OSTbeta to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption.
16269519 OSTalpha/OSTbeta expression is induced by bile acids through ligand-dependent transactivation of both OST genes by the nuclear bile acid receptor/farnesoid X receptor (FXR).
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AA Sequence

MEPGRTQIKLDPRYTADLLEVLKTNYGIPSACFSQPPTAAQLLRALGPVELALTSILTLLALGSIAIFLE      1 - 70
DAVYLYKNTLCPIKRRTLLWKSSAPTVVSVLCCFGLWIPRSLVLVEMTITSFYAVCFYLLMLVMVEGFGG     71 - 140
KEAVLRTLRDTPMMVHTGPCCCCCPCCPRLLLTRKKLQLLMLGPFQYAFLKITLTLVGLFLVPDGIYDPA    141 - 210
DISEGSTALWINTFLGVSTLLALWTLGIISRQARLHLGEQNMGAKFALFQVLLILTALQPSIFSVLANGG    211 - 280
QIACSPPYSSKTRSQVMNCHLLILETFLMTVLTRMYYRRKDHKVGYETFSSPDLDLNLKA              281 - 340
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Text Mined References (17)

PMID Year Title
24816252 2014 An atlas of genetic influences on human blood metabolites.
24703425 2015 The organic solute transporters alpha and beta are induced by hypoxia in human hepatocytes.
22535958 2012 ?-Subunit of the Ost?-Ost? organic solute transporter is required not only for heterodimerization and trafficking but also for function.
21691099 2011 Pleiotropic functions of the organic solute transporter Ost?-Ost?.
20538072 2010 Getting the mOST from OST: Role of organic solute transporter, OSTalpha-OSTbeta, in bile acid and steroid metabolism.
18847488 2008 N-Glycosylation of the alpha subunit does not influence trafficking or functional activity of the human organic solute transporter alpha/beta.
18469300 2008 Reduced ileal expression of OSTalpha-OSTbeta in non-obese gallstone disease.
17332473 2007 Protein-protein interactions and membrane localization of the human organic solute transporter.
16713569 2006 A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
16423920 2006 Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents.
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