Tbio CUZD1 CUB and zona pellucida-like domain-containing protein 1

Protein Summary

Description

CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes. May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells.

Uniprot Accession IDs

• Q86UP6
• A8K080
• B2RN93
• D3DRE5
• Q7Z660
• Q7Z661
• Q86SG1
• Q86UP5
• Q9HAR7
• CUB and ZP domain-containing protein 1

Gene Name

• CUZD1

Ensembl ID

• ENST00000368904
• ENSP00000357900
• ENSG00000138161
• ENST00000392790
• ENSP00000376540

Symbol

• ERG1
• ERG-1
• UO-44
• ITMAP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
small molecule perturbation	0.65
cellular component	0.51
tissue sample	0.49
tissue	0.48

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.75   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 138   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.75   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0