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  7. Cytoplasmic polyadenylation element-binding protein 2

Tbio Cytoplasmic polyadenylation element-binding protein 2

May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity).

The protein encoded by this gene is highly similar to cytoplasmic polyadenylation element binding protein (CPEB), an mRNA-binding protein that regulates cytoplasmic polyadenylation of mRNA as a trans factor in oogenesis and spermatogenesis. Studies of the similar gene in mice suggested a possible role of this protein in transcriptionally inactive haploid spermatids. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 10
PubMed Score 6.14
PubTator Score 3.81

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
non-small cell lung cancer 2798 1.41902798485675E-12
Amyotrophic Lateral Sclerosis 432 1.06689778278478E-6
acute quadriplegic myopathy 1157 6.38026993776219E-6
atypical teratoid / rhabdoid tumor 4369 6.69001100880995E-6
Pick disease 1893 2.47480868943905E-4
medulloblastoma, large-cell 6234 0.00157471762046815
medulloblastoma 1524 0.0024691417860409
mucosa-associated lymphoid tissue lymphoma 480 0.0064478865626482
glioblastoma 5572 0.0134943755809328
progressive supranuclear palsy 674 0.0142622604545362
astrocytic glioma 2241 0.0145477051235176
spina bifida 1064 0.0226439600247717
gastric carcinoma 832 0.0325527491286752
acute myeloid leukemia 785 0.0417162171515595
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0456450648008496

Expression

  Differential Expression (15)

Disease log2 FC p
astrocytic glioma -1.800 0.015
medulloblastoma -1.500 0.002
atypical teratoid / rhabdoid tumor -2.300 0.000
glioblastoma -1.100 0.013
medulloblastoma, large-cell -3.200 0.002
Amyotrophic Lateral Sclerosis 1.300 0.000
acute quadriplegic myopathy 1.483 0.000
non-small cell lung cancer -1.097 0.000
intraductal papillary-mucinous neoplasm ... 1.300 0.046
spina bifida -1.616 0.023
Pick disease -1.100 0.000
progressive supranuclear palsy -1.100 0.014
gastric carcinoma -1.100 0.033
mucosa-associated lymphoid tissue lympho... 1.127 0.006
acute myeloid leukemia 1.400 0.042

Synonym

Accession Q7Z5Q1 E7EPM3 F5H160 Q3B8N6 Q3MI89 Q3MI90 Q3MI92 Q7Z5Q0 CPE-BP2
Symbols CPEB-2
CPE-BP2
hCPEB-2

Gene

CPEB2

PANTHER Protein Class (4)

  Ortholog (8)

Species Source
Chimp OMA EggNOG Inparanoid
Macaque EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog EggNOG Inparanoid
Horse EggNOG Inparanoid
Pig EggNOG Inparanoid
Platypus EggNOG Inparanoid

 GO Function (10)

 GO Component (5)

 GO Process (7)

 Compartment GO Term (21)

See all...

 HCA RNA Cell Line (56)

See all...

Pathway (4)

 UniProt Keyword (8)

Gene RIF (3)

PMID Text
26398195 CPEB1, 2, and 4, are essential to successful mitotic cell division.
26304115 findings demonstrate that the regulation of CPEB2 mRNA splicing is a key mechanism in AnR and a driving force in TNBC metastasis
12672660 Functional studies of the mouse homolog

AA Sequence 

MPPPSPDSENGFYPGLPSSMNPAFFPSFSPVSPHGCTGLSVPTSGGGGGGFGGPFSATAVPPPPPPAMNI      1 - 70
PQQQPPPPAAPQQPQSRRSPVSPQLQQQHQAAAAAFLQQRNSYNHHQPLLKQSPWSNHQSSGWGTGSMSW     71 - 140
GAMHGRDHRRTGNMGIPGTMNQISPLKKPFSGNVIAPPKFTRSTPSLTPKSWIEDNVFRTDNNSNTLLPL    141 - 210
QVRSSLQLPAWGSDSLQDSWCTAAGTSRIDQDRSRMYDSLNMHSLENSLIDIMRAEHDPLKGRLSYPHPG    211 - 280
TDNLLMLNGRSSLFPIDDGLLDDGHSDQVGVLNSPTCYSAHQNGERIERFSRKVFVGGLPPDIDEDEITA    281 - 350
SFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQEESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRP    351 - 420
WNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFS    421 - 490
NQQSYIAAISARFVQLQHGDIDKRVEVKPYVLDDQMCDECQGARCGGKFAPFFCANVTCLQYYCEFCWAN    491 - 560
IHSRAGREFHKPLVKEGADRPRQIHFRWN                                             561 - 589
//

Text Mined References (11)

PMID Year Title
26398195 2015 Global Analysis of CPEBs Reveals Sequential and Non-Redundant Functions in Mitotic Cell Cycle.
26304115 2015 The Alternative Splicing of Cytoplasmic Polyadenylation Element Binding Protein 2 Drives Anoikis Resistance and the Metastasis of Triple Negative Breast Cancer.
22681889 2012 The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
22658674 2012 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
20639532 2010 A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neurons.
18752464 2009 Cytoplasmic polyadenylation-element-binding protein (CPEB)1 and 2 bind to the HIF-1alpha mRNA 3'-UTR and modulate HIF-1alpha protein expression.
15815621 2005 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12672660 2003 CPEB2, a novel putative translational regulator in mouse haploid germ cells.
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