| Tbio | Cytoplasmic polyadenylation element-binding protein 2 |
May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity).
The protein encoded by this gene is highly similar to cytoplasmic polyadenylation element binding protein (CPEB), an mRNA-binding protein that regulates cytoplasmic polyadenylation of mRNA as a trans factor in oogenesis and spermatogenesis. Studies of the similar gene in mice suggested a possible role of this protein in transcriptionally inactive haploid spermatids. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is highly similar to cytoplasmic polyadenylation element binding protein (CPEB), an mRNA-binding protein that regulates cytoplasmic polyadenylation of mRNA as a trans factor in oogenesis and spermatogenesis. Studies of the similar gene in mice suggested a possible role of this protein in transcriptionally inactive haploid spermatids. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| NCBI Gene PubMed Count | 10 |
| Grant Count | 1 |
| Funding | $219,576 |
| PubMed Score | 6.14 |
| PubTator Score | 3.81 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | -1.800 | 0.015 |
| medulloblastoma | -1.500 | 0.002 |
| atypical teratoid / rhabdoid tumor | -2.300 | 0.000 |
| glioblastoma | -1.100 | 0.013 |
| medulloblastoma, large-cell | -3.200 | 0.002 |
| Amyotrophic Lateral Sclerosis | 1.300 | 0.000 |
| acute quadriplegic myopathy | 1.483 | 0.000 |
| non-small cell lung cancer | -1.097 | 0.000 |
| intraductal papillary-mucinous neoplasm ... | 1.300 | 0.046 |
| spina bifida | -1.616 | 0.023 |
| Pick disease | -1.100 | 0.000 |
| progressive supranuclear palsy | -1.100 | 0.014 |
| gastric carcinoma | -1.100 | 0.033 |
| mucosa-associated lymphoid tissue lympho... | 1.127 | 0.006 |
| acute myeloid leukemia | 1.400 | 0.042 |
MPPPSPDSENGFYPGLPSSMNPAFFPSFSPVSPHGCTGLSVPTSGGGGGGFGGPFSATAVPPPPPPAMNI 1 - 70 PQQQPPPPAAPQQPQSRRSPVSPQLQQQHQAAAAAFLQQRNSYNHHQPLLKQSPWSNHQSSGWGTGSMSW 71 - 140 GAMHGRDHRRTGNMGIPGTMNQISPLKKPFSGNVIAPPKFTRSTPSLTPKSWIEDNVFRTDNNSNTLLPL 141 - 210 QVRSSLQLPAWGSDSLQDSWCTAAGTSRIDQDRSRMYDSLNMHSLENSLIDIMRAEHDPLKGRLSYPHPG 211 - 280 TDNLLMLNGRSSLFPIDDGLLDDGHSDQVGVLNSPTCYSAHQNGERIERFSRKVFVGGLPPDIDEDEITA 281 - 350 SFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQEESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRP 351 - 420 WNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFS 421 - 490 NQQSYIAAISARFVQLQHGDIDKRVEVKPYVLDDQMCDECQGARCGGKFAPFFCANVTCLQYYCEFCWAN 491 - 560 IHSRAGREFHKPLVKEGADRPRQIHFRWN 561 - 589 //
| PMID | Year | Title |
|---|---|---|
| 26398195 | 2015 | Global Analysis of CPEBs Reveals Sequential and Non-Redundant Functions in Mitotic Cell Cycle. |
| 26304115 | 2015 | The Alternative Splicing of Cytoplasmic Polyadenylation Element Binding Protein 2 Drives Anoikis Resistance and the Metastasis of Triple Negative Breast Cancer. |
| 22681889 | 2012 | The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. |
| 22658674 | 2012 | Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. |
| 20639532 | 2010 | A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neurons. |
| 18752464 | 2009 | Cytoplasmic polyadenylation-element-binding protein (CPEB)1 and 2 bind to the HIF-1alpha mRNA 3'-UTR and modulate HIF-1alpha protein expression. |
| 15815621 | 2005 | Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
| 12672660 | 2003 | CPEB2, a novel putative translational regulator in mouse haploid germ cells. |
| More... |
