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Tdark UPF0505 protein C16orf62

Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability (PubMed:25355947).

 Comments

Property Summary

NCBI Gene PubMed Count 12
PubMed Score 0.72
PubTator Score 0.77

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count P-value
osteosarcoma 7950 1.6e-07
malignant mesothelioma 3232 4.8e-07
ovarian cancer 8520 5.6e-06
tuberculosis 2010 1.5e-05
medulloblastoma, large-cell 6241 3.6e-05
colon cancer 1478 1.5e-04
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 1.0
Liver cancer 604 0.0 0.6

Expression

  Differential Expression (6)

Disease log2 FC p
colon cancer -1.300 1.5e-04
malignant mesothelioma -1.400 4.8e-07
medulloblastoma, large-cell -1.100 3.6e-05
osteosarcoma -1.712 1.6e-07
ovarian cancer -1.100 5.6e-06
tuberculosis 1.100 1.5e-05

Synonym

Accession Q7Z3J2 A8K2M1 O43329 Q69YI1 Q6PDA0 Q7L371 Q86W66 Q8WXA5 Q9H0L7 Q9H7C8
Symbols C16orf62

Gene

VPS35L

  Ortholog (12)

Species Source Disease
Inparanoid OMA EggNOG
Inparanoid OMA
OMA EggNOG
OMA EggNOG
OMA EggNOG
OMA EggNOG
Inparanoid OMA
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
OMA EggNOG

 UniProt Keyword (11)

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 GO Component (4)

 GO Process (3)

 Compartment GO Term (38)

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 HCA RNA Cell Line (56)

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Gene RIF (5)

AA Sequence 

MAVFPWHSRNRNYKAEFASCRLEAVPLEFGDYHPLKPITVTESKTKKVNRKGSTSSTSSSSSSSVVDPLS      1 - 70
SVLDGTDPLSMFAATADPAALAAAMDSSRRKRDRDDNSVVGSDFEPWTNKRGEILARYTTTEKLSINLFM     71 - 140
GSEKGKAGTATLAMSEKVRTRLEELDDFEEGSQKELLNLTQQDYVNRIEELNQSLKDAWASDQKVKALKI    141 - 210
VIQCSKLLSDTSVIQFYPSKFVLITDILDTFGKLVYERIFSMCVDSRSVLPDHFSPENANDTAKETCLNW    211 - 280
FFKIASIRELIPRFYVEASILKCNKFLSKTGISECLPRLTCMIRGIGDPLVSVYARAYLCRVGMEVAPHL    281 - 350
KETLNKNFFDFLLTFKQIHGDTVQNQLVVQGVELPSYLPLYPPAMDWIFQCISYHAPEALLTEMMERCKK    351 - 420
LGNNALLLNSVMSAFRAEFIATRSMDFIGMIKECDESGFPKHLLFRSLGLNLALADPPESDRLQILNEAW    421 - 490
KVITKLKNPQDYINCAEVWVEYTCKHFTKREVNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDF    491 - 560
SVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQQEPTKDPVILNALLHVCKTMHDSVNALTLEDEK    561 - 630
RMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHSVNRLAMETRKVMKGNHSRKTAAF    631 - 700
VRACVAYCFITIPSLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSES    701 - 770
FLLEFLCNFFSTLLIVPDHPEHGVLFLVRELLNVIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHI    771 - 840
DKVDSNDSLYGGDSKFLAENNKLCETVMAQILEHLKTLAKDEALKRQSSLGLSFFNSILAHGDLRNNKLN    841 - 910
QLSVNLWHLAQRHGCADTRTMVKTLEYIKKQSKQPDMTHLTELALRLPLQTRT                     911 - 963
//

Text Mined References (17)

PMID Year Title