| Tdark | Protein very KIND |
RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence (PubMed:24788352).
The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endothelial cells partially reversed the senescence, showing that this gene could potentially be targeted by anti-aging therapies. [provided by RefSeq, Dec 2016]
The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endothelial cells partially reversed the senescence, showing that this gene could potentially be targeted by anti-aging therapies. [provided by RefSeq, Dec 2016]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| oligodendroglioma | 2850 | 5.1e-14 |
| astrocytoma | 1146 | 3.1e-12 |
| glioblastoma | 5792 | 1.2e-11 |
| atypical teratoid / rhabdoid tumor | 5112 | 2.3e-09 |
| medulloblastoma, large-cell | 6241 | 9.9e-09 |
| group 3 medulloblastoma | 4104 | 1.1e-08 |
| Astrocytoma, Pilocytic | 3081 | 2.7e-08 |
| posterior fossa group A ependymoma | 468 | 1.9e-07 |
| adult high grade glioma | 3801 | 2.1e-07 |
| primitive neuroectodermal tumor | 3035 | 1.6e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -2.200 | 2.1e-07 |
| astrocytoma | -1.100 | 3.1e-12 |
| Astrocytoma, Pilocytic | -2.800 | 2.7e-08 |
| atypical teratoid / rhabdoid tumor | -2.600 | 2.3e-09 |
| glioblastoma | -2.500 | 1.2e-11 |
| group 3 medulloblastoma | -3.800 | 1.1e-08 |
| medulloblastoma, large-cell | -3.400 | 9.9e-09 |
| oligodendroglioma | -1.300 | 5.1e-14 |
| posterior fossa group A ependymoma | -1.300 | 1.9e-07 |
| primitive neuroectodermal tumor | -1.900 | 1.6e-02 |
MQAMDPAAADLYEEDGKDLDFYDFEPLPTLPEDEENVSLADILSLRDRGLSEQEAWAVCLECSLSMRSVA 1 - 70 HAAIFQSLCITPDTLAFNTSGNVCFMEQLSDDPEGAFVPPEFDVTGNTFEAHIYSLGATLKAALEYVAEP 71 - 140 TLEPRLSQDLEALLSRMQAEDPGDRPDLESIIALCEEKLQLTSSCRVCRSLSAVGRRVLSIESFGALQDV 141 - 210 SESSWRERPAPGNAGPRRPPGDPSTDPEVLPTPEGPESETSRGPRASPTKALLSTPVRNGESHSREGLAG 211 - 280 LVLDAERTLGELDRDALRRSRLRKVQTFPRLLSDSPEATLCLPLTRGKSQLPISELFSPDPRKAFLDRKN 281 - 350 GLSSFQAQPKCRLWPEQEPEHQLGRVPCAGRSTDRGPGVPGSPGQPETSHPSQGPAEAPADPRDASGEAQ 351 - 420 TPRDDERIPEGARQLESAAAEQWVSLQDLLSQLGRPFREYELWALCLACLRALQTRPEHPAYLCLDSVLV 421 - 490 AEDGAVLFQPPPANGSYDSFFLAPELAEERLVTEKASVYCVAAVLWTAAKFSVPRNHKLALPRRLKTLLL 491 - 560 DMARRSAPERPSAAEAIKVCGSYLLQRGMDSRKILAHLRASICQVYQEEETISLQNAFSVVELKPSVAPA 561 - 630 PEPSPGFLPVNSDTGLVAVPGPVPGQHPCGEEATQLPAAFTSEATHFKPIVLAQNASVARDQPALAQEES 631 - 700 EERGGQREGEGEEKLSLEAHAGSPSLKTPDGPVPGPGPQGAAPEPLGASVQRDSAQGRPCPPPQAPANQP 701 - 770 EGASSAAPGSPVPAPPTKASALPVEQGPAEPIPPGVASGGLRPDALGPTTAHHGPRHPPKPPRSKATERP 771 - 840 GQEPEGPGATPAGERDDQSPDSVPERPRPADRRLCLPCVDASPLPGRTACPSLQEATRLIQEEFAFDGYL 841 - 910 DNGLEALIMGEYIFALKDLTFATFCGAISEKFCDLYWDEKLLQNLFKVVNGQASPSPSTAEEAGSQLEGS 911 - 980 QSPRSPSSKRPSLHRLGKEKPAMARTSSRAPCSPTSVSDVDSDALSRGNFEVGFRPQRSVKAERAQQPEA 981 - 1050 GEDRRPAGGASDVEAVTRLARSKGVGPALSPGPAGFQSCSPGWCSAFYEADCFGADVHNYVKDLGRQQAD 1051 - 1120 GALPDAQSPELEQQLMMEKRNYRKTLKFYQKLLQKEKRNKGSDVKTMLSKLKGQLEEMKSRVQFLSLVKK 1121 - 1190 YLQVMYAERWGLEPCTLPVIVNIAAAPCDTLDFSPLDESSSLIFYNVNKHPGGRQKARILQAGTPLGLMA 1191 - 1260 YLYSSDAFLEGYVQQFLYTFRYFCTPHDFLHFLLDRINSTLTRAHQDPTSTFTKIYRRSLCVLQAWVEDC 1261 - 1330 YAVDFPRNSGLLGKLEDFISSKILPLDGSAKHLLGLLEVGMDRRAEGNPRGTDLENPREAEEDARPFNAL 1331 - 1400 CKRLSEDGISRKSFPWRLPRGNGLVLPPHKERPYTIAAALPKPCFLEDFYGPCAKTSEKGPYFLTEYSTH 1401 - 1470 QLFSQLTLLQQELFQKCHPVHFLNSRALGVMDKSTAIPKASSSESLSAKTCSLFLPNYVQDKYLLQLLRN 1471 - 1540 ADDVSTWVAAEIVTSHTSKLQVNLLSKFLLIAKSCYEQRNFATAMQILSGLEHLAVRQSPAWRILPAKIA 1541 - 1610 EVMEELKAVEVFLKSDSLCLMEGRRFRAQPTLPSAHLLAMHIQQLETGGFTMTNGAHRWSKLRNIAKVVS 1611 - 1680 QVHAFQENPYTFSPDPKLQSYLKQRIARFSGADISTLAADSRANFHQVSSEKHSRKIQDKLRRMKATFQ 1681 - 1749 //
