Ankyrin repeat and SAM domain-containing protein 3

Property Summary

NCBI Gene PubMed Count	8
PubMed Score	3.60

PubTator Score	1.11

Knowledge Summary

Patent

No data available

TINX Plot

Disease (2)

JensenLab Experiment COSMIC
JensenLab Text Mining

Disease	Target Count	Z-score	Confidence
Carcinoma	11493	0.0	0.5

Disease	Target Count	Z-score	Confidence
Nephronophthisis	80	4.497	2.2
Cystic kidney disease	26	3.846	1.9
Autosomal dominant polycystic kidney disease	31	3.007	1.5

Expression

Specificity
Differential

Uterus 17,618

Ovary 17,971

Brain - Cerebellar Hemisphere 18,015

Brain - Cerebellum 17,983

Pituitary 18,147

Prostate 18,213

Thyroid 18,024

Vagina 17,834

Colon - Sigmoid 18,089

Artery - Aorta 17,896

Nerve - Tibial 18,007

Artery - Coronary 17,949

Testis 18,518

Esophagus - Gastroesophageal Junction 18,000

Esophagus - Muscularis 18,017

Spleen 17,614

Artery - Tibial 17,631

Adrenal Gland 18,071

Adipose - Visceral (Omentum) 17,937

Brain - Hypothalamus 18,169

Brain - Frontal Cortex (BA9) 18,069

Brain - Spinal cord (cervical c-1) 17,973

Brain - Cortex 18,039

Breast - Mammary Tissue 18,103

Skin - Not Sun Exposed (Suprapubic) 18,081

Adipose - Subcutaneous 18,110

Esophagus - Mucosa 18,076

Cells - Transformed fibroblasts 17,577

Brain - Nucleus accumbens (basal ganglia... 18,024

Skin - Sun Exposed (Lower leg) 17,968

Brain - Anterior cingulate cortex (BA24) 17,989

Lung 18,057

Stomach 17,879

Minor Salivary Gland 18,005

Brain - Substantia nigra 17,981

Brain - Caudate (basal ganglia) 18,001

Kidney - Cortex 17,329

Small Intestine - Terminal Ileum 17,954

Brain - Hippocampus 18,011

Brain - Putamen (basal ganglia) 17,863

Brain - Amygdala 18,006

Heart - Atrial Appendage 17,896

Cells - EBV-transformed lymphocytes 18,186

Pancreas 18,123

Liver 18,071

Colon - Transverse 17,825

Heart - Left Ventricle 18,006

Muscle - Skeletal 17,778

Whole Blood 17,439

Placenta 6,083

Platelets 6,131

NK Cells 8,475

Adult Lung 6,663

Adult Rectum 8,022

Fetal Liver 8,402

Adult Pancreas 9,168

Adult Liver 9,113

Fetal Gut 8,640

Fetal Brain 7,866

Adult Ovary 10,192

Adult Adrenal 8,475

Adult Colon 7,915

Adult Heart 6,506

Adult Retina 10,115

Adult Frontal Cortex 9,048

Adult Kidney 6,723

Adult Testis 10,836

Monocytes 7,422

B Cells 9,086

CD4 Cells 7,773

Adult Gallbladder 7,612

Adult Spinal Cord 7,594

CD8 Cells 9,840

Adult Urinary Bladder 7,592

Adult Esophagus 4,936

Fetal Heart 9,228

Adult Prostate 8,952

Fetal Testis 7,955

Colon

adipose tissue 15,837

adrenal gland 15,963

appendix 16,247

bone marrow 14,571

breast 16,063

cerebral cortex 16,630

cervix, uterine 15,871

colon 15,959

duodenum 15,975

endometrium 16,349

epididymis 15,863

esophagus 15,898

fallopian tube 16,245

gallbladder 16,333

heart muscle 14,972

kidney 15,917

liver 14,587

lung 16,312

lymph node 15,833

ovary 15,408

pancreas 14,070

parathyroid gland 14,769

placenta 15,937

prostate 16,460

rectum 15,705

salivary gland 14,981

seminal vesicle 15,918

skeletal muscle 14,011

skin 16,206

small intestine 16,154

smooth muscle 15,857

spleen 15,972

stomach 16,099

testis 17,936

thyroid gland 15,959

tonsil 15,400

urinary bladder 15,814

Liver and Pancreas 16,750

Digestive Tract 17,369

Urinary Tract 16,678

Endocrine System 18,159

Blood and immune system 16,909

Respiratory system 16,393

Female tissues 17,400

Male tissues 17,142

Skin and soft tissues 17,230

Nervous System 16,725

Cardiovascular System 15,192

See source...

Hypodermal seam cell 30

See source...

Synonym

Accession	Q6ZW76 B4DWU4 D3DUE2 Q8TF25
Symbols

Gene

ANKS3

Ortholog (14)

Species	Source	Disease
Chimp 14,140	OMA EggNOG
Macaque 12,761	OMA EggNOG
Mouse 16,570	Inparanoid OMA EggNOG
Rat 15,117	Inparanoid OMA EggNOG
Dog 15,073	Inparanoid OMA EggNOG
Horse 14,252	Inparanoid OMA EggNOG
Cow 15,320	Inparanoid OMA EggNOG
Pig 10,168	OMA EggNOG
Opossum 12,230	Inparanoid OMA EggNOG
Platypus 5,703	OMA EggNOG
Chicken 7,827	Inparanoid OMA EggNOG
Anole lizard 10,588	Inparanoid OMA EggNOG
Xenopus 10,468	Inparanoid OMA EggNOG
Zebrafish 9,726	OMA EggNOG

UniProt Keyword (10)

Complete proteome 20,231

Polymorphism 12,194

Reference proteome 20,231

Repeat 4,916

Alternative splicing 10,528

Phosphoprotein 8,216

3D-structure 6,226

Coiled coil 2,153

ANK repeat 258

Hydroxylation 133

Compartment GO Term (2)

Cytosol 6,686

Nucleoplasm 5,077

IMPC Phenotype (1)

preweaning lethality, complete penetranc... 979

HCA RNA Cell Line (56)

A-431 16,131

A549 15,174

AF22 16,160

AN3-CA 15,648

ASC TERT1 14,842

BEWO 16,726

BJ 15,448

BJ hTERT+ 15,353

BJ hTERT+ SV40 Large T+ 15,609

BJ hTERT+ SV40 Large T+ RasG12V 15,493

See all...

PDB (2)

...
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Gene RIF (2)

AA Sequence

MSELSDEASEPELLNRSLSMWHGLGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGW      1 - 70
TPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALF     71 - 140
HCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAK    141 - 210
QYGHMKIVALMDTYSPSLPKSLYRSPEKYEDLSSSDESCPAPQRQRPCRKKGVSIHEGPRALARITGIGL    211 - 280
GGRAPRPRYEQAPPRGYVTFNSSGENPLEEEGLCCRDVTSPINERDVESSSSSSSREEHAFCANLGPVQS    281 - 350
SSSSEGLARAQGLSSEASVESNEDSDHACKSSARKQAKSYMKTKNPDSQWPPRAATDREGFLAESSPQTQ    351 - 420
RAPYSGPQDLAALLEQIGCLKYLQVFEEQDVDLRIFLTLTESDLKEIGITLFGPKRKMTSAIARWHSSAR    421 - 490
PPGDALELAYADRLEAEMQELAIQLHKRCEEVEATRGQVCQEQELRAVVESCLLEQDRAREDLQARLRET    491 - 560
WALARDAALVLDQLRACQAELSSRVRQDQPPGAATLGLAVPPADSKGWQASLQAMSLPELSGALEDRVRE    561 - 630
MGQALCLVTQSLEKLQVLNGKKWRET                                                631 - 656
//

Text Mined References (8)

Summary
Details

	PMID	Year	Title