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Tdark Ankyrin repeat and SAM domain-containing protein 3


 Comments

Property Summary

NCBI Gene PubMed Count 7
Grant Count 2
R01 Count 2
Funding $115,246.8
PubMed Score 3.28
PubTator Score 1.11

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (3)

Disease Z-score Confidence
Nephronophthisis 74 4.479 2.2
Polycystic kidney disease 54 4.011 2.0
Cystic kidney disease 25 3.882 1.9

Expression

Synonym

Accession Q6ZW76 B4DWU4 D3DUE2 Q8TF25
Symbols

Gene

ANKS3

 Grant Application (2)

PDB

4NJ8   4NL9  

 Compartment GO Term (0)

Pathway (1)

 UniProt Keyword (10)

Gene RIF (1)

PMID Text
24998259 Study finds that ANKS3-SAM polymerizes and ANKS6-SAM can bind to one end of the polymer; study presents crystal structures of both the ANKS3-SAM polymer and the ANKS3-SAM/ANKS6-SAM complex, revealing the molecular details of their association.

AA Sequence 

MSELSDEASEPELLNRSLSMWHGLGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGW      1 - 70
TPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALF     71 - 140
HCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAK    141 - 210
QYGHMKIVALMDTYSPSLPKSLYRSPEKYEDLSSSDESCPAPQRQRPCRKKGVSIHEGPRALARITGIGL    211 - 280
GGRAPRPRYEQAPPRGYVTFNSSGENPLEEEGLCCRDVTSPINERDVESSSSSSSREEHAFCANLGPVQS    281 - 350
SSSSEGLARAQGLSSEASVESNEDSDHACKSSARKQAKSYMKTKNPDSQWPPRAATDREGFLAESSPQTQ    351 - 420
RAPYSGPQDLAALLEQIGCLKYLQVFEEQDVDLRIFLTLTESDLKEIGITLFGPKRKMTSAIARWHSSAR    421 - 490
PPGDALELAYADRLEAEMQELAIQLHKRCEEVEATRGQVCQEQELRAVVESCLLEQDRAREDLQARLRET    491 - 560
WALARDAALVLDQLRACQAELSSRVRQDQPPGAATLGLAVPPADSKGWQASLQAMSLPELSGALEDRVRE    561 - 630
MGQALCLVTQSLEKLQVLNGKKWRET                                                631 - 656
//

Text Mined References (7)

PMID Year Title
24998259 2014 Characterization of the SAM domain of the PKD-related protein ANKS6 and its interaction with ANKS3.
17081983 2006 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
16964243 2006 A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
16713569 2006 A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11853319 2001 Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins.