Property Summary

NCBI Gene PubMed Count 33
Grant Count 12
R01 Count 7
Funding $546,856.66
PubMed Score 16.77
PubTator Score 30.34

Knowledge Summary

Patent

No data available

Expression

 GO Function (1)

Gene RIF (33)

PMID Text
26790954 Rab11-FIP1A associates with and regulates trafficking at an early step in the process of membrane recycling
26152716 GTPase Rab11, but not Rab4, is involved in the recycling of hERG channels.
26034275 Second-site reversion mutation in theHIV-1 gp41 cytoplasmic tail is required to restore HIV-1 Env incorporation in YW795SL gp41 mutant in all cell types
26034275 Second-site reversion mutation in theHIV-1 gp41 cytoplasmic tail is required to restore HIV-1 Env incorporation in YW795SL gp41 mutant in all cell types
26034275 Second-site reversion mutation in theHIV-1 gp41 cytoplasmic tail is required to restore HIV-1 Env incorporation in YW795SL gp41 mutant in all cell types
26034275 Second-site reversion mutation in theHIV-1 gp41 cytoplasmic tail is required to restore HIV-1 Env incorporation in YW795SL gp41 mutant in all cell types
26032412 We find that Rab14 indeed binds to RCP, albeit with reduced affinity relative to conventional Rab11-FIP and Rab25-FIP complexes. However, in vivo, Rab11 recruits RCP onto biological membranes.
24302731 Mitochondrial remodeling was associated with increased proximity between Rab11a and mitochondrial membranes, changes in fusion-fission dynamics, and mitochondrial relocalization of the Drp1, which was regulated by the Rab11a effector protein FIP1/RCP.
24040321 rab11 effector protein FIP1 regulates adiponectin trafficking and secretion
23592992 findings support a model for HIV-1 Env incorporation in which specific targeting to the particle assembly microdomain on the plasma membrane is mediated by FIP1C and Rab14
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AA Sequence

MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEA      1 - 70
TFELPSLLSSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKERG     71 - 140
EIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGKNKDSGSDTASAIIPSTTPSVDSDDESVVKD    141 - 210
KKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSASDVMSHKRTAS    211 - 280
TDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFR    281 - 350
KKHLFSSTENLAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEAT    351 - 420
KEAKESKKPESRRSSLLSLMTGKKDVAKGSEGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKD    421 - 490
TAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKPRLEVSPEAQPTARLPSPTDS    491 - 560
PSSLPPLPSSSGQASVPSELGHGADTQSSESPSVFSSLSSPIAAPISTSTPIESWPLVDRGQAKSEGPPL    561 - 630
LPKAELQTESLTPVPNSGSSALGSLFKQPSFPANKGTEDSLMGRTRETGTEKNTSSLELEESLPEQPETG    631 - 700
RQEEELPRFPCKKQDYSPSSGEAQEVPFALSLSSDGAVSPVGELAAGGDRDLESQAGSLVESKARDAAEE    701 - 770
VAPPLPMGASVPSIDSMMRKLEEMGLNLRKDQKKTKKRVSFSEQLFTEEAVAGAALLVEGHSSCPQELNP    771 - 840
AWSVAGNASDGEPPESPHAEDSERESVTTPGPATCGAPASPADHLLLPSQEESFSEVPMSEASSAKDTPL    841 - 910
FRMEGEDALVTQYQSKASDHEGLLSDPLSDLQLVSDFKSPIMADLNLSLPSIPEVASDDERIDQVEDDGD    911 - 980
QVEDDGETAKSSTLDIGALSLGLVVPCPERGKGPSGEADRLVLGEGLCDFRLQAPQASVTAPSEQTTEFG    981 - 1050
IHKPHLGKSSSLDKQLPGPSGGEEEKPMGNGSPSPPPGTSLDNPVPSPSPSEIFPVTHSFPSSAHSDTHH   1051 - 1120
TSTAESQKKATAEGSAGRVENFGKRKPLLQAWVSPSETHPVSAQPGAGTGSAKHRLHPVKPMNAMATKVA   1121 - 1190
NCSLGTATIISENLNNEVMMKKYSPSDPAFAYAQLTHDELIQLVLKQKETISKKEFQVRELEDYIDNLLV   1191 - 1260
RVMEETPNILRIPTQVGKKAGKM                                                  1261 - 1283
//

Text Mined References (43)

PMID Year Title
26790954 2016 Rab11-FIP1A regulates early trafficking into the recycling endosomes.
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
26152716 2015 Rab11-dependent Recycling of the Human Ether-a-go-go-related Gene (hERG) Channel.
26032412 2015 Structure-Function Analyses of the Interactions between Rab11 and Rab14 Small GTPases with Their Shared Effector Rab Coupling Protein (RCP).
24302731 2014 A functional interplay between the small GTPase Rab11a and mitochondria-shaping proteins regulates mitochondrial positioning and polarization of the actin cytoskeleton downstream of Src family kinases.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24144296 2013 Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
24040321 2013 The rab11 effector protein FIP1 regulates adiponectin trafficking and secretion.
23592992 2013 Rab11-FIP1C and Rab14 direct plasma membrane sorting and particle incorporation of the HIV-1 envelope glycoprotein complex.
23283983 2013 Rab11-family interacting proteins define spatially and temporally distinct regions within the dynamic Rab11a-dependent recycling system.
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