Tbio DOK6 Docking protein 6

Protein Summary

Description

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance. DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q6PKX4
• A6NNG3
• Q4V9S3
• Q8WUZ8
• Q96HI2
• Q96LU2

Gene Name

• DOK6

Ensembl ID

• ENST00000382713
• ENSP00000372160
• ENSG00000206052

Symbol

• DOK5L
• DOK5L
• HsT3226

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.86
microRNA	0.65
tissue sample	0.65
phenotype	0.63
disease	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.34   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 153   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.34   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0