Property Summary

NCBI Gene PubMed Count 10
PubMed Score 3.16
PubTator Score 2.93

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count P-value
oligodendroglioma 2849 2.02328473373192E-15
ovarian cancer 8492 8.71771185710578E-14
lung adenocarcinoma 2714 2.20241346055964E-13
pituitary cancer 1972 1.87538652779791E-8
adult high grade glioma 2148 1.52857568215176E-7
pilocytic astrocytoma 3086 1.24654807957657E-6
glioblastoma 5572 9.66930320458291E-6
atypical teratoid / rhabdoid tumor 4369 9.24708562609993E-5
interstitial cystitis 2299 6.39610215308165E-4
sonic hedgehog group medulloblastoma 1482 7.96692553471036E-4
medulloblastoma, large-cell 6234 0.0019694451945805
astrocytic glioma 2241 0.00447848742360547
ependymoma 2514 0.00467832105438368
primitive neuroectodermal tumor 3031 0.0240553801189397
subependymal giant cell astrocytoma 2287 0.0360047367331981
Disease Target Count Z-score Confidence
Hemolytic anemia 70 0.0 2.0
Osteoporosis 259 0.0 1.0
Rheumatoid Arthritis 1171 0.0 2.0

Expression

  Differential Expression (15)

Disease log2 FC p
astrocytic glioma -3.000 0.004
ependymoma -2.800 0.005
oligodendroglioma -2.400 0.000
glioblastoma -5.100 0.000
sonic hedgehog group medulloblastoma -2.400 0.001
atypical teratoid / rhabdoid tumor -3.900 0.000
medulloblastoma, large-cell -3.400 0.002
primitive neuroectodermal tumor -2.200 0.024
interstitial cystitis -2.300 0.001
lung adenocarcinoma -2.300 0.000
adult high grade glioma -5.500 0.000
pilocytic astrocytoma -2.900 0.000
subependymal giant cell astrocytoma -2.285 0.036
ovarian cancer -2.000 0.000
pituitary cancer 3.300 0.000

Synonym

Accession Q6PKX4 A6NNG3 Q4V9S3 Q8WUZ8 Q96HI2 Q96LU2
Symbols DOK5L
HsT3226

Gene

  Ortholog (10)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA Inparanoid
Opossum OMA EggNOG
Chicken OMA Inparanoid
Zebrafish OMA Inparanoid

 Compartment GO Term (2)

Gene RIF (4)

PMID Text
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
20210798 DOK-6 is involved in RET signaling with less influence when compared with DOK-1, DOK-4, and SHC.
18187620 Knockdown of docking protein 6 (DOK6) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells
15286081 Dok-6 binds to the phosphorylated Ret Tyr(1062) residue resulting in phosphorylation of tyrosine residue(s) located within the unique C terminus of Dok-6 predominantly through a Src-dependent mechanism

AA Sequence

MASNFNDIVKQGYVKIRSRKLGIFRRCWLVFKKASSKGPRRLEKFPDEKAAYFRNFHKVTELHNIKNITR      1 - 70
LPRETKKHAVAIIFHDETSKTFACESELEAEEWCKHLCMECLGTRLNDISLGEPDLLAAGVQREQNERFN     71 - 140
VYLMPTPNLDIYGECTMQITHENIYLWDIHNAKVKLVMWPLSSLRRYGRDSTWFTFESGRMCDTGEGLFT    141 - 210
FQTREGEMIYQKVHSATLAIAEQHERLMLEMEQKARLQTSLTEPMTLSKSISLPRSAYWHHITRQNSVGE    211 - 280
IYSLQGHGFGSSKMSRAQTFPSYAPEQSEEAQQPLSRSSSYGFSYSSSLIQ                       281 - 331
//

Text Mined References (11)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
24483146 2014 Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
20548944 2010 An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
20210798 2010 Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells.
16273093 2006 A quantitative protein interaction network for the ErbB receptors using protein microarrays.
16177791 2005 DNA sequence and analysis of human chromosome 18.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15286081 2004 Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
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