Tdark | Polypeptide N-acetylgalactosaminyltransferase 18 |
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
Comments
Disease | Target Count | P-value |
---|---|---|
non-small cell lung carcinoma | 413 | 1.38143315517088E-24 |
lung adenocarcinoma | 2714 | 3.45309278058449E-13 |
ovarian cancer | 8492 | 1.03096260131444E-8 |
group 4 medulloblastoma | 1875 | 2.0920357706618E-6 |
pilocytic astrocytoma | 3086 | 4.19009500904337E-6 |
posterior fossa group B ependymoma | 1530 | 1.0612278274037E-5 |
facioscapulohumeral dystrophy | 286 | 1.97469384822204E-5 |
adult high grade glioma | 2148 | 2.56474426290981E-5 |
Breast cancer | 3099 | 4.98397132122164E-5 |
intraductal papillary-mucinous adenoma (IPMA) | 2956 | 1.62017260398298E-4 |
primitive neuroectodermal tumor | 3031 | 2.64238717688545E-4 |
atypical teratoid / rhabdoid tumor | 4369 | 0.0020763663341843 |
astrocytic glioma | 2241 | 0.00443766640497939 |
adrenocortical carcinoma | 1427 | 0.00514661451310124 |
glioblastoma | 5572 | 0.00852054301949895 |
active Crohn's disease | 918 | 0.015563334250685 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Rheumatoid Arthritis | 1171 | 0.0 | 2.0 |
Type 2 diabetes mellitus | 192 | 0.0 | 1.0 |
Disease | log2 FC | p |
---|---|---|
astrocytic glioma | -1.100 | 0.004 |
group 4 medulloblastoma | -2.000 | 0.000 |
atypical teratoid / rhabdoid tumor | -1.100 | 0.002 |
glioblastoma | -1.100 | 0.009 |
primitive neuroectodermal tumor | -1.600 | 0.000 |
adrenocortical carcinoma | 1.277 | 0.005 |
non-small cell lung carcinoma | -1.100 | 0.000 |
intraductal papillary-mucinous adenoma (... | -1.100 | 0.000 |
active Crohn's disease | 1.008 | 0.016 |
lung adenocarcinoma | -2.100 | 0.000 |
adult high grade glioma | -1.600 | 0.000 |
pilocytic astrocytoma | -1.500 | 0.000 |
posterior fossa group B ependymoma | -1.200 | 0.000 |
Breast cancer | 1.200 | 0.000 |
ovarian cancer | -2.100 | 0.000 |
facioscapulohumeral dystrophy | -1.800 | 0.000 |
PMID | Text |
---|---|
20379614 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) |
20080650 | Observational study of gene-disease association. (HuGE Navigator) |
19240061 | Observational study of gene-disease association. (HuGE Navigator) |
18976975 | Knockdown of UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 4 (GALNTL4) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells |
MVCTRKTKTLVSTCVILSGMTNIICLLYVGWVTNYIASVYVRGQEPAPDKKLEEDKGDTLKIIERLDHLE 1 - 70 NVIKQHIQEAPAKPEEAEAEPFTDSSLFAHWGQELSPEGRRVALKQFQYYGYNAYLSDRLPLDRPLPDLR 71 - 140 PSGCRNLSFPDSLPEVSIVFIFVNEALSVLLRSIHSAMERTPPHLLKEIILVDDNSSNEELKEKLTEYVD 141 - 210 KVNSQKPGFIKVVRHSKQEGLIRSRVSGWRAATAPVVALFDAHVEFNVGWAEPVLTRIKENRKRIISPSF 211 - 280 DNIKYDNFEIEEYPLAAQGFDWELWCRYLNPPKAWWKLENSTAPIRSPALIGCFIVDRQYFQEIGLLDEG 281 - 350 MEVYGGENVELGIRVWQCGGSVEVLPCSRIAHIERAHKPYTEDLTAHVRRNALRVAEVWMDEFKSHVYMA 351 - 420 WNIPQEDSGIDIGDITARKALRKQLQCKTFRWYLVSVYPEMRMYSDIIAYGVLQNSLKTDLCLDQGPDTE 421 - 490 NVPIMYICHGMTPQNVYYTSSQQIHVGILSPTVDDDDNRCLVDVNSRPRLIECSYAKAKRMKLHWQFSQG 491 - 560 GPIQNRKSKRCLELQENSDLEFGFQLVLQKCSGQHWSITNVLRSLAS 561 - 607 //
PMID | Year | Title |
---|---|---|
22491018 | 2013 | Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. |
22238593 | 2012 | A genome-wide association search for type 2 diabetes genes in African Americans. |
22186971 | 2012 | UDP-N-acetyl-?-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases: completion of the family tree. |
22171061 | 2012 | Characterization of ppGalNAc-T18, a member of the vertebrate-specific Y subfamily of UDP-N-acetyl-?-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases. |
20379614 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | |
20080650 | 2010 | Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. |
19240061 | 2009 | Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. |
15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
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