Tdark | Centrosomal protein of 85 kDa |
Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856).
This gene encodes a protein that belongs to the centrosome-associated family of proteins. The centrosome is a subcellular organelle in the animal cell that functions as a microtubule organizing center and is involved in cell-cycle progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
This gene encodes a protein that belongs to the centrosome-associated family of proteins. The centrosome is a subcellular organelle in the animal cell that functions as a microtubule organizing center and is involved in cell-cycle progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Comments
Disease | Target Count | P-value |
---|---|---|
malignant mesothelioma | 3163 | 1.6243068806391E-6 |
medulloblastoma, large-cell | 6234 | 6.24375109458948E-6 |
osteosarcoma | 7933 | 0.00250940779140678 |
lung cancer | 4473 | 0.00953817957809318 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Endometriosis | 535 | 3.034 | 1.5 |
Disease | log2 FC | p |
---|---|---|
malignant mesothelioma | 1.700 | 0.000 |
osteosarcoma | 1.150 | 0.003 |
medulloblastoma, large-cell | 1.300 | 0.000 |
lung cancer | 1.200 | 0.010 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG Inparanoid |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA Inparanoid |
Dog | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Opossum | OMA EggNOG Inparanoid |
Platypus | OMA EggNOG |
Anole lizard | OMA Inparanoid |
Xenopus | OMA EggNOG Inparanoid |
PMID | Text |
---|---|
26220856 | Cep85 is a bona fide Nek2A-binding partner that surrounds the proximal ends of centrioles where it cooperates with PP1gamma (also known as PPP1CC) to antagonize Nek2A |
19460752 | Knockdown of centrosomal protein 85kDa (CEP85) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells |
MAMQEKYPTEGISHVTSPSSDVIQKGSSLGTEWQTPVISEPFRSRFSRCSSVADSGDTAIGTSCSDIAED 1 - 70 FCSSSGSPPFQPIKSHVTIPTAHVMPSTLGTSPAKPNSTPVGPSSSKLPLSGLAESVGMTRNGDLGAMKH 71 - 140 SPGLSRDLMYFSGATGENGIEQSWFPAVGHERQEEARKFDIPSMESTLNQSAMMETLYSDPHHRVRFHNP 141 - 210 RTSTSKELYRVLPEAKKAPGSGAVFERNGPHSNSSGVLPLGLQPAPGLSKPLPSQVWQPSPDTWHPREQS 211 - 280 CELSTCRQQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEKELLIDKQRKH 281 - 350 ISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASE 351 - 420 VEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLE 421 - 490 DHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEET 491 - 560 SGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRT 561 - 630 AVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQDLQAVCSIVTQRAQGHDP 631 - 700 NLSLLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQLRRDIEDLRTTMSDRYAQDMGENCVTQ 701 - 762 //
PMID | Year | Title |
---|---|---|
26471995 | 2015 | Characterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction. |
26220856 | 2015 | Characterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction. |
23251661 | 2012 | Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. |
23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
21399614 | 2011 | Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. |
21044950 | 2011 | Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. |
20068231 | 2010 | Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. |
18985028 | 2008 | Hepatitis C virus infection protein network. |
18669648 | 2008 | A quantitative atlas of mitotic phosphorylation. |
17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. |
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