| Tdark | Centrosomal protein of 85 kDa |
Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856).
This gene encodes a protein that belongs to the centrosome-associated family of proteins. The centrosome is a subcellular organelle in the animal cell that functions as a microtubule organizing center and is involved in cell-cycle progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
This gene encodes a protein that belongs to the centrosome-associated family of proteins. The centrosome is a subcellular organelle in the animal cell that functions as a microtubule organizing center and is involved in cell-cycle progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Comments
| Disease | Z-score | Confidence |
|---|---|---|
| Endometriosis 535 | 3.034 | 1.5 |
| lung cancer 4,466 | ||
| malignant mesothelioma 3,162 | ||
| medulloblastoma, large-cell 6,234 | ||
| osteosarcoma 7,933 |
| Disease | log2 FC | p |
|---|---|---|
| malignant mesothelioma | 1.700 | 0.000 |
| osteosarcoma | 1.150 | 0.003 |
| medulloblastoma, large-cell | 1.300 | 0.000 |
| lung cancer | 1.200 | 0.010 |
| PMID | Text |
|---|---|
| 26220856 | Cep85 is a bona fide Nek2A-binding partner that surrounds the proximal ends of centrioles where it cooperates with PP1gamma (also known as PPP1CC) to antagonize Nek2A |
| 19460752 | Knockdown of centrosomal protein 85kDa (CEP85) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells |
MAMQEKYPTEGISHVTSPSSDVIQKGSSLGTEWQTPVISEPFRSRFSRCSSVADSGDTAIGTSCSDIAED 1 - 70 FCSSSGSPPFQPIKSHVTIPTAHVMPSTLGTSPAKPNSTPVGPSSSKLPLSGLAESVGMTRNGDLGAMKH 71 - 140 SPGLSRDLMYFSGATGENGIEQSWFPAVGHERQEEARKFDIPSMESTLNQSAMMETLYSDPHHRVRFHNP 141 - 210 RTSTSKELYRVLPEAKKAPGSGAVFERNGPHSNSSGVLPLGLQPAPGLSKPLPSQVWQPSPDTWHPREQS 211 - 280 CELSTCRQQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEKELLIDKQRKH 281 - 350 ISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASE 351 - 420 VEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLE 421 - 490 DHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEET 491 - 560 SGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRT 561 - 630 AVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQDLQAVCSIVTQRAQGHDP 631 - 700 NLSLLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQLRRDIEDLRTTMSDRYAQDMGENCVTQ 701 - 762 //
| PMID | Year | Title |
|---|---|---|
| 26471995 | 2015 | Characterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction. |
| 26220856 | 2015 | Characterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction. |
| 23251661 | 2012 | Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
| 21399614 | 2011 | Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. |
| 21044950 | 2011 | Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. |
| 20068231 | 2010 | Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. |
| 18985028 | 2008 | Hepatitis C virus infection protein network. |
| 18669648 | 2008 | A quantitative atlas of mitotic phosphorylation. |
| 17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. |
| More... |
