Property Summary

NCBI Gene PubMed Count 25
Grant Count 30
R01 Count 6
Funding $8,129,812.64
PubMed Score 23.00
PubTator Score 18.69

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (15)

Disease log2 FC p
Rheumatoid Arthritis -1.100 0.007
malignant mesothelioma -2.300 0.000
astrocytic glioma -1.600 0.016
oligodendroglioma -1.200 0.049
psoriasis -1.100 0.001
osteosarcoma -1.728 0.000
glioblastoma -1.100 0.002
atypical teratoid / rhabdoid tumor -1.300 0.003
medulloblastoma, large-cell -1.900 0.000
primitive neuroectodermal tumor -1.900 0.001
group 4 medulloblastoma -1.900 0.000
pilocytic astrocytoma -1.800 0.000
acute myeloid leukemia -1.300 0.034
ovarian cancer -1.400 0.000
pituitary cancer 1.100 0.003

 GO Function (1)

Gene RIF (13)

PMID Text
25254322 LRRC16A plays a role in adult respiratory distress syndrome pathophysiology by interacting with, and being mediated through, platelets.
24318514 shown for the first time that CARMIL/LRRC16A was associated with gout, which could be due to urate transportsome failure
23904264 The results also suggest that the ability of CARMIL1 to inhibit CP in cells may be regulated.
22411988 Data suggest that CARMIL promotes uncapping by binding to a freely accessible site on Capping protein (CP) bound to a filament barbed end and inducing a change in the conformation of the actin-binding surface of CP.
20800603 Observational study of gene-disease association. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
20162743 Observational study of gene-disease association. (HuGE Navigator)
20162742 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19890391 Observational study of gene-disease association. (HuGE Navigator)
19861489 Observational study of gene-disease association. (HuGE Navigator)
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AA Sequence

MTEESSDVPRELIESIKDVIGRKIKISVKKKVKLEVKGDKVENKVLVLTSCRAFLVTARIPTKLELTFSY      1 - 70
LEIHGVVCSKSAQMIVETEKCSISMKMASPEDVSEVLAHIGTCLRKIFPGLSPVRIMKKVSMEPSERLAS     71 - 140
LQALWDSQTVAEQGPCGGFSQMYACVCDWLGFSYREEVQWDVDTIYLTQDTRELNLQDFSHLDHRDLIPI    141 - 210
IAALEYNQWFTKLSSKDLKLSTDVCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNSGLHT    211 - 280
INLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLR    281 - 350
GDDLSHMYNFLAQPNAIVHLDLSNTECSLDMVCGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFF    351 - 420
SSSLALMHINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSLDIS    421 - 490
DNGLESDLSTLIVWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEESPLQSLSLADSKLKTEV    491 - 560
TIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKNYTLR    561 - 630
FMPIPMYDASQALKTNPEKTEDALQKIENYLLRNHETRKYLQEQAYRLQQGIVTSTTQQMIDRICVKVQD    631 - 700
HLNSLRNCGGDAIQEDLKSAERLMRDAKNSKTLLPNLYHVGGASWAGASGLLSSPIQETLESMAGEVTRV    701 - 770
VDEQLKALLESMVDAAENLCPNVMKKAHIRQDLIHASTEKISIPRTFVKNVLLEQSGIDILNKISEVKLT    771 - 840
VASFLSDRIVDEILDALSHCHHKLADHFSRRGKTLPQQESLEIELAEEKPVKRSIITVEELTEIERLEDL    841 - 910
DTCMMTPKSKRKSIHSRMLRPVSRAFEMEFDLDKALEEVPIHIEDPPFPSLRQEKRSSGFISELPSEEGK    911 - 980
KLEHFTKLRPKRNKKQQPTQAAVCAANIVSQDGEQNGLMGRVDEGVDEFFTKKVTKMDSKKWSTRGSESH    981 - 1050
ELNEGGDEKKKRDSRKSSGFLNLIKSRSKSERPPTILMTEEPSSPKGAVRSPPVDCPRKDTKAAEHNGNS   1051 - 1120
ERIEEIKTPDSFEESQGEEIGKVERSDSKSSPQAGRRYGVQVMGSGLLAEMKAKQEKRAACAQKKLGNDA   1121 - 1190
VSQDSSSPALSGVERSDGGGAVPKLHPGLPENRFGLGTPEKNTKAEPKAEAGSRSRSSSSTPTSPKPLLQ   1191 - 1260
SPKPSLAARPVIPQKPRTASRPDDIPDSPSSPKVALLPPVLKKVPSDKERDGQSSPQPSPRTFSQEVSRR   1261 - 1330
SWGQQAQEYQEQKQRSSSKDGHQGSKSNDSGEEAEKEFIFV                                1331 - 1371
//

Text Mined References (36)

PMID Year Title
26578515 2016 Cell Migration and Invadopodia Formation Require a Membrane-binding Domain of CARMIL2.
25254322 2015 Platelet count mediates the contribution of a genetic variant in LRRC16A to ARDS risk.
24318514 2014 Common variant of leucine-rich repeat-containing 16A (LRRC16A) gene is associated with gout susceptibility.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23904264 2013 Physiological role of the interaction between CARMIL1 and capping protein.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
22423221 2012 A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.
22411988 2012 Mechanism for CARMIL protein inhibition of heterodimeric actin-capping protein.
22139419 2011 New gene functions in megakaryopoiesis and platelet formation.
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