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Tdark Coiled-coil and C2 domain-containing protein 1B

Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells.

 Comments

Property Summary

NCBI Gene PubMed Count 10
PubMed Score 0.91
PubTator Score 2.06

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count P-value
osteosarcoma 7950 6.9e-05
ovarian cancer 8520 1.6e-04
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.7

Expression

  Differential Expression (2)

Disease log2 FC p
osteosarcoma -1.041 6.9e-05
ovarian cancer -1.200 1.6e-04

Synonym

Accession Q5T0F9 Q49AE8 Q5T0F8 Q5T0G0 Q6ZNQ1 Q96AP3 Q96I04 Q96JJ1
Symbols

Gene

CC2D1B

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (9)

 GO Function (3)

 GO Component (3)

 GO Process (2)

 Compartment GO Term (23)

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 IMPC Phenotype (3)

 MGI Phenotype (3)

 HCA RNA Cell Line (56)

See all...

Protein-protein Interaction (8)

FAT4   FREM2   GFM2   FAT3   PCDH20   CELSR2   HSPA14   PCDH7  

Gene RIF (3)

AA Sequence 

MMPGPRPRKGPQARGQGVAAAKQMGLFMEFGPEDMLLGMDEAEDDEDLEAELLALTGEAQTTGKKPAPKG      1 - 70
QAPLPMAHIEKLAADCMRDVEEEEEEEGLEEDAELLTELQEVLGVDEETEPLDGDEVADPGGSEEENGLE     71 - 140
DTEPPVQTAVLTASAPAAQAGASQGLHALLEERIHNYREAAASAKEAGEAAKARRCERGLKTLESQLASV    141 - 210
RRGRKINEDEIPPPVALGKRPLAPQEPANRSPETDPPAPPALESDNPSQPETSLPGISAQPVSDLDPDPR    211 - 280
ALLSSRQREYKVAALSAKRAGELDRARELMRIGKRFGAVLEALEKGQPVDLSAMPPAPEDLKPQQASQAP    281 - 350
TAPSVIPPAVERVQPVMAPDVPATPVAPTESQTVLDALQQRLNKYREAGIQARSGGDERKARMHERIAKQ    351 - 420
YQDAIRAHRAGRKVNFAELPVPPGFPPIPGLESTMGVEEDAVAATLAAAEKLASAEDSAPADKDEDEPPG    421 - 490
HLQGEPPAQAPVAKKPARPTVPSSQRLPEPRASSSKESPSPSVREQLALLEARKLQYQRAALQAKRSQDL    491 - 560
EQAKAYLRVAKWLEAQIIQARSGRPVDLSKVPSPLTDEEGDFILIHHEDLRLSQKAEEVYAQLQKMLLEQ    561 - 630
QEKCLLFSKQFMHQGNVAETTRFEKLAQDRKKQLEILQLAQAQGLDPPTHHFELKTFQTVRIFSELNSTE    631 - 700
MHLIIVRGMNLPAPPGVTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKNTNSPEFDQLFKLNINRNHRGFK    701 - 770
RVIQSKGIKFEIFHKGSFFRSDKLVGTAHLKLERLENECEIREIVEVLDGRKPTGGKLEVKVRLREPLSG    771 - 840
QDVQMVTENWLVLEPRGL                                                        841 - 858
//

Text Mined References (15)

PMID Year Title