Property Summary

NCBI Gene PubMed Count 7
PubMed Score 0.00
PubTator Score 1.60

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
psoriasis 6685 5.73956438261316E-133
lung carcinoma 2844 3.10554631529697E-22
non-small cell lung cancer 2798 2.79876898491088E-15
adrenocortical carcinoma 1427 1.29312215053561E-10
inflammatory breast cancer 404 1.13646015388275E-7
atypical teratoid/rhabdoid tumor 1095 1.84098170031332E-7
intraductal papillary-mucinous carcinoma (IPMC) 2988 9.03890115428694E-5
invasive ductal carcinoma 2950 1.04995397592415E-4
sonic hedgehog group medulloblastoma 1482 3.97588151583308E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00123016148756832
pancreatic ductal adenocarcinoma liver metastasis 1795 0.00526757681722369
interstitial cystitis 2299 0.00807987320198459
subependymal giant cell astrocytoma 2287 0.012980939162792
gastric carcinoma 832 0.0268426734404236
Disease Target Count Z-score Confidence
Lewy body dementia 2 3.297 1.6

Expression

Gene

PANTHER Protein Class (1)

PDB

2OPW   3OBZ  

  Ortholog (11)

Gene RIF (1)

PMID Text
21530488 PHYHD1A has the double-stranded beta-helix fold and Fe(II) and cosubstrate binding residues characteristic of the 2-oxoglutarate dependent oxygenases and catalyzes the conversion of 2-oxoglutarate to succinate and CO(2) in an iron-dependent manner.

AA Sequence

MACLSPSQLQKFQQDGFLVLEGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYF      1 - 70
LSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAHDPVFKSITHSFKVQTLARSLGLQMPVVVQS     71 - 140
MYIFKQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSA    141 - 210
PGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAYTFHLMEASGTTWSPENWLQP    211 - 280
TAELPFPQLYT                                                               281 - 291
//

Text Mined References (11)

PMID Year Title
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
21530488 2011 Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase.
21044950 2011 Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
17567994 2007 Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions.
17525332 2007 ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15164053 2004 DNA sequence and analysis of human chromosome 9.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
More...