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Tdark Protein-lysine N-methyltransferase METTL10

S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.

 Comments

Property Summary

NCBI Gene PubMed Count 5
PubMed Score 1.69
PubTator Score 1.33

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
osteosarcoma 7933 6.39410521621155E-6
atypical teratoid / rhabdoid tumor 4369 2.00176009105729E-4
adult high grade glioma 2148 5.60251263703771E-4
medulloblastoma, large-cell 6234 7.3883956521072E-4
glioblastoma 5572 0.00129267459882746
pituitary cancer 1972 0.00665493584099607

Expression

  Differential Expression (6)

Disease log2 FC p
osteosarcoma -2.503 0.000
atypical teratoid / rhabdoid tumor -1.300 0.000
glioblastoma -1.200 0.001
medulloblastoma, large-cell -1.500 0.001
adult high grade glioma -1.300 0.001
pituitary cancer 1.100 0.007

Synonym

Accession Q5JPI9 A8MPY7
Symbols C10orf138

Gene

METTL10

PANTHER Protein Class (2)

 GO Function (1)

 GO Component (1)

 Compartment GO Term (8)

 HCA RNA Cell Line (56)

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Pathway (4)

 UniProt Keyword (9)

Gene RIF (1)

PMID Text
16385451 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence 

MSSGADGGGGAAVAARSDKGSPGEDGFVPSALGTREHWDAVYERELQTFREYGDTGEIWFGEESMNRLIR      1 - 70
WMQKHKIPLDASVLDIGTGNGVFLVELAKFGFSNITGIDYSPSAIQLSGSIIEKEGLSNIKLKVEDFLNL     71 - 140
STQLSGFHICIDKGTFDAISLNPDNAIEKRKQYVKSLSRVLKVKGFFLITSCNWTKEELLNEFSEGWSTV    141 - 210
AGFWLTAALTSWAQAIFSTSASRVGGTTGTHHHAWIIFVFLAETRFCHVVQAGLELLGSSDSPTWPPKVL    211 - 280
GLYHARPSLAF                                                               281 - 291
//

Text Mined References (11)

PMID Year Title
25144183 2014 Selenium-based S-adenosylmethionine analog reveals the mammalian seven-beta-strand methyltransferase METTL10 to be an EF1A1 lysine methyltransferase.
23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
19413330 2009 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
16385451 2006 A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
15164054 2004 The DNA sequence and comparative analysis of human chromosome 10.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
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