Tdark | Protein-lysine N-methyltransferase METTL10 |
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.
Comments
Disease | Target Count | P-value |
---|---|---|
osteosarcoma | 7933 | 6.39410521621155E-6 |
atypical teratoid / rhabdoid tumor | 4369 | 2.00176009105729E-4 |
adult high grade glioma | 2148 | 5.60251263703771E-4 |
medulloblastoma, large-cell | 6234 | 7.3883956521072E-4 |
glioblastoma | 5572 | 0.00129267459882746 |
pituitary cancer | 1972 | 0.00665493584099607 |
Disease | log2 FC | p |
---|---|---|
osteosarcoma | -2.503 | 0.000 |
atypical teratoid / rhabdoid tumor | -1.300 | 0.000 |
glioblastoma | -1.200 | 0.001 |
medulloblastoma, large-cell | -1.500 | 0.001 |
adult high grade glioma | -1.300 | 0.001 |
pituitary cancer | 1.100 | 0.007 |
MSSGADGGGGAAVAARSDKGSPGEDGFVPSALGTREHWDAVYERELQTFREYGDTGEIWFGEESMNRLIR 1 - 70 WMQKHKIPLDASVLDIGTGNGVFLVELAKFGFSNITGIDYSPSAIQLSGSIIEKEGLSNIKLKVEDFLNL 71 - 140 STQLSGFHICIDKGTFDAISLNPDNAIEKRKQYVKSLSRVLKVKGFFLITSCNWTKEELLNEFSEGWSTV 141 - 210 AGFWLTAALTSWAQAIFSTSASRVGGTTGTHHHAWIIFVFLAETRFCHVVQAGLELLGSSDSPTWPPKVL 211 - 280 GLYHARPSLAF 281 - 291 //
PMID | Year | Title |
---|---|---|
25144183 | 2014 | Selenium-based S-adenosylmethionine analog reveals the mammalian seven-beta-strand methyltransferase METTL10 to be an EF1A1 lysine methyltransferase. |
23251661 | 2012 | Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. |
23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
22814378 | 2012 | N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. |
19413330 | 2009 | Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. |
18669648 | 2008 | A quantitative atlas of mitotic phosphorylation. |
17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. |
16385451 | 2006 | A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. |
15164054 | 2004 | The DNA sequence and comparative analysis of human chromosome 10. |
14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
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