| Disease | Target Count |
|---|---|
| Colonic Neoplasms | 126 |
| Disease | Target Count | P-value |
|---|---|---|
| ulcerative colitis | 2087 | 4.24125977581977E-6 |
| colon cancer | 1475 | 2.13240805391641E-4 |
| active Crohn's disease | 918 | 0.0104526199589054 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2988 | 0.0259162698576924 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Dentin dysplasia | 19 | 3.37 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| intraductal papillary-mucinous carcinoma... | 2.900 | 0.026 |
| colon cancer | -2.400 | 0.000 |
| active Crohn's disease | -1.441 | 0.010 |
| ulcerative colitis | -2.200 | 0.000 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA EggNOG Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Horse | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG |
| Pig | OMA EggNOG Inparanoid |
| Opossum | OMA EggNOG Inparanoid |
| Platypus | OMA EggNOG |
| Anole lizard | OMA EggNOG Inparanoid |
| Xenopus | OMA EggNOG Inparanoid |
| Zebrafish | OMA Inparanoid |
| PMID | Text |
|---|---|
| 24474695 | Meprin metalloproteases A and B inactivate interleukin 6 |
| 24388959 | Variants rs17468190 (G/T) in the MEP1A gene are associated with glucose and insulin metabolism in overweight/obese central European women with polycystic ovary syndrome. |
| 22923609 | Proteolytically active meprinalpha leads to an increase in EGFR and ERK1/2 phosphorylation and subsequently enhances cell proliferation and migration |
| 22326557 | The present results indicate that a TNF-alpha-mediated down-regulation of CDX2 can be related to suppressed expression of MEP1A during intestinal inflammation. |
| 22096485 | Meprin-alpha activity is regulated differently in primary tumors and metastases of colorectal cancer. By virtue of its pro-migratory and pro-angiogenic activity, meprin-alpha may promote tumor progression in colorectal cancer. |
| 20806899 | Cystatin C was an inhibitor for human meprin alpha(K(i) = 8.5 x 10(-6) M) but, interestingly, not for meprin beta. |
| 20631730 | meprins could be important players in several remodeling processes involving collagen fiber deposition |
| 19262505 | MEP1A is a UC susceptibility gene and indicate that decreased meprin-alpha expression is associated with intestinal inflammation in IBD patients and in a mouse experimental model of IBD. |
| 19262505 | Observational study of gene-disease association. (HuGE Navigator) |
| 17195012 | Mephrin beta induced a dramatic change in cell morphology and reduced the cell number, indicating a function in terminal differentiation, whereas meprin alpha did not affect cell viability, and may play a role in basal keratinocyte proliferation. |
| More... |
MAWIRSTCILFFTLLFAHIAAVPIKYLPEENVHDADFGEQKDISEINLAAGLDLFQGDILLQKSRNGLRD 1 - 70 PNTRWTFPIPYILADNLGLNAKGAILYAFEMFRLKSCVDFKPYEGESSYIIFQQFDGCWSEVGDQHVGQN 71 - 140 ISIGQGCAYKAIIEHEILHALGFYHEQSRTDRDDYVNIWWDQILSGYQHNFDTYDDSLITDLNTPYDYES 141 - 210 LMHYQPFSFNKNASVPTITAKIPEFNSIIGQRLDFSAIDLERLNRMYNCTTTHTLLDHCTFEKANICGMI 211 - 280 QGTRDDTDWAHQDSAQAGEVDHTLLGQCTGAGYFMQFSTSSGSAEEAALLESRILYPKRKQQCLQFFYKM 281 - 350 TGSPSDRLVVWVRRDDSTGNVRKLVKVQTFQGDDDHNWKIAHVVLKEEQKFRYLFQGTKGDPQNSTGGIY 351 - 420 LDDITLTETPCPTGVWTVRNFSQVLENTSKGDKLQSPRFYNSEGYGFGVTLYPNSRESSGYLRLAFHVCS 421 - 490 GENDAILEWPVENRQVIITILDQEPDVRNRMSSSMVFTTSKSHTSPAINDTVIWDRPSRVGTYHTDCNCF 491 - 560 RSIDLGWSGFISHQMLKRRSFLKNDDLIIFVDFEDITHLSQTEVPTKGKRLSPQGLILQGQEQQVSEEGS 561 - 630 GKAMLEEALPVSLSQGQPSRQKRSVENTGPLEDHNWPQYFRDPCDPNPCQNDGICVNVKGMASCRCISGH 631 - 700 AFFYTGERCQAVQVHGSVLGMVIGGTAGVIFLTFSIIAILSQRPRK 701 - 746 //
| PMID | Year | Title |
|---|---|---|
| 24474695 | 2014 | Meprin metalloproteases inactivate interleukin 6. |
| 24388959 | 2014 | Association of MEP1A gene variants with insulin metabolism in central European women with polycystic ovary syndrome. |
| 23123160 | 2012 | Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3. |
| 22923609 | 2012 | Meprin? transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migration. |
| 22326557 | 2012 | TNF-?-induced down-regulation of CDX2 suppresses MEP1A expression in colitis. |
| 22096485 | 2011 | Enhanced activity of meprin-?, a pro-migratory and pro-angiogenic protease, in colorectal cancer. |
| 20806899 | 2010 | Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases. |
| 20631730 | 2010 | Processing of procollagen III by meprins: new players in extracellular matrix assembly? |
| 19262505 | 2009 | MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease. |
| 17976009 | 2007 | Human and mouse homo-oligomeric meprin A metalloendopeptidase: substrate and inhibitor specificities. |
| More... |
