Property Summary

NCBI Gene PubMed Count 165
Grant Count 327
R01 Count 209
Funding $42,805,803.52
PubMed Score 587.50
PubTator Score 650.00

Knowledge Summary

Patent

No data available

Expression

Synonym

Accession Q14242 A8K2Y0 B4DQC3 B7Z5C7 J3KMX6 Q12775 Q6GTW7 Q8N7J7 PSGL-1
Symbols CLA
CD162
PSGL1
PSGL-1

Gene

PDB

1G1S  

Gene RIF (152)

PMID Text
26975045 PSGL-1 is a novel receptor for S. pneumoniae that contributes to protection against invasive pneumococcal disease.
26539491 This study provides a better understanding of the biology of P-selectin and PSGL-1 and their roles in dissemination and resensitization of Multiple myeloma treatment.
26124272 E-selectin interactions with glycoprotein ligands (CD44/hematopoietic cell E-/L-selectin ligand and PSGL-1) mediate the initial capturing of cells out of flow.
26115234 The solution structure of CCL19 is reported. It contains a canonical chemokine domain. Chemical shift mapping shows the N-termini of PSGL-1 and CCR7 have overlapping binding sites for CCL19 and binding is competitive.
25445472 CD162 staining and the staining degree, with the other standard immunohistochemical stains, were shown to be beneficial in the diagnosis of multiple myeloma disease.
25428141 Report influence of SELPLG variation on leukocyte-platelet interactions in cardiovascular disease.
25425738 Taken together, these results show that beta-adducin is a pivotal lipid raft-associated protein in PSGL-1-mediated neutrophil rolling on P-selectin.
25405250 expression of P-selectin and P-selectin glycoprotein ligand-1, forming an auto-augmented loop of porcine aortic endothelial cells and platelet activation
25320329 Host membrane protein PSGL-1, CD43, and CD44 association with assembling HIV-1 Gag is driven by polybasic sequences present in the cytoplasmic tails of the membrane proteins and in Gag.
25320329 HIV-1 Vpu downregulates the cell surface expression of selectin P ligand (SELPLG, CD162)
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AA Sequence

MPLQLLLLLILLGPGNSLQLWDTWADEAEKALGPLLARDRRQATEYEYLDYDFLPETEPPEMLRNSTDTT      1 - 70
PLTGPGTPESTTVEPAARRSTGLDAGGAVTELTTELANMGNLSTDSAAMEIQTTQPAATEAQTTQPVPTE     71 - 140
AQTTPLAATEAQTTRLTATEAQTTPLAATEAQTTPPAATEAQTTQPTGLEAQTTAPAAMEAQTTAPAAME    141 - 210
AQTTPPAAMEAQTTQTTAMEAQTTAPEATEAQTTQPTATEAQTTPLAAMEALSTEPSATEALSMEPTTKR    211 - 280
GLFIPFSVSSVTHKGIPMAASNLSVNYPVGAPDHISVKQCLLAILILALVATIFFVCTVVLAVRLSRKGH    281 - 350
MYPVRNYSPTEMVCISSLLPDGGEGPSATANGGLSKAKSPGLTPEPREDREGDDLTLHSFLP            351 - 412
//

Text Mined References (172)

PMID Year Title
26975045 2016 PSGL-1 on Leukocytes is a Critical Component of the Host Immune Response against Invasive Pneumococcal Disease.
26627825 2016 Extracellular Fibrinogen-binding Protein (Efb) from Staphylococcus aureus Inhibits the Formation of Platelet-Leukocyte Complexes.
26539491 2015 Inhibition of P-Selectin and PSGL-1 Using Humanized Monoclonal Antibodies Increases the Sensitivity of Multiple Myeloma Cells to Bortezomib.
26124272 2015 Quantitative Characterization of E-selectin Interaction with Native CD44 and P-selectin Glycoprotein Ligand-1 (PSGL-1) Using a Real Time Immunoprecipitation-based Binding Assay.
26115234 2015 Solution Structure of CCL19 and Identification of Overlapping CCR7 and PSGL-1 Binding Sites.
25445472 2015 Relationship of P-selectin glycoprotein ligand-1 to prognosis in patients with multiple myeloma.
25428141 2015 Impact of variables of the P-selectin - P-selectin glycoprotein ligand-1 axis on leukocyte-platelet interactions in cardiovascular disease.
25425738 2015 Lipid raft-associated ?-adducin is required for PSGL-1-mediated neutrophil rolling on P-selectin.
25405250 Role of P-selectin and P-selectin glycoprotein ligand-1 interaction in the induction of tissue factor expression on human platelets after incubation with porcine aortic endothelial cells.
25320329 2015 Basic motifs target PSGL-1, CD43, and CD44 to plasma membrane sites where HIV-1 assembles.
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