Property Summary

NCBI Gene PubMed Count 18
PubMed Score 13.26
PubTator Score 9.68

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count P-value
breast carcinoma 1614 1.00368543406726E-28
Breast cancer 3099 4.41237890335478E-9
tuberculosis 1563 6.81295722129788E-9
group 4 medulloblastoma 1875 1.89447062458828E-8
ependymoma 2514 2.99413620874765E-6
primitive neuroectodermal tumor 3031 1.58977184066982E-4
cystic fibrosis 1670 2.72314970327896E-4
psoriasis 6685 4.14292866803907E-4
osteosarcoma 7933 6.4972423929582E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 8.58296566371546E-4
pilocytic astrocytoma 3086 0.00367968184017196
medulloblastoma, large-cell 6234 0.0040708528257169
pediatric high grade glioma 2712 0.00470758122967792
atypical teratoid / rhabdoid tumor 4369 0.00568688308891597
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00868783223301042
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00938693272848689
invasive ductal carcinoma 2950 0.0104726496853248
oligodendroglioma 2849 0.0109789733446633
astrocytic glioma 2241 0.0132483877673511
aldosterone-producing adenoma 664 0.0185403190740568
glioblastoma 5572 0.0282763345178194
subependymal giant cell astrocytoma 2287 0.0361994070266957
Disease Target Count Z-score Confidence
Primary biliary cirrhosis 45 0.0 2.0

Expression

Synonym

Accession Q13506 O75383 O75384 Q6GTU1 Q9UEV1
Symbols

Gene

PDB

2YUF  

  Ortholog (10)

 GWAS Trait (1)

Gene RIF (5)

PMID Text
23935197 These data suggest that type I IFN stimulation induces a rapid recruitment of a repressive Egr3/Nab1 complex that silences transcription from the ifngr1 promoter.
21239760 Data show that the suppressive effect of valproic acid on chondrocytes is not due to reduced expression or recruitment of Egr-1 to the mPGES-1 promoter and involves upregulation of NAB1.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
17853270 Methylation pattern of the corresponding NGFI-A binding site in the human glucocorticoid receptor exon 1-F specific promoter in post mortem hippocampal tissue.
12030330 mutations in the human NABI gene are most likely not involved in the pathogenesis of peripheral neuropathies.

AA Sequence

MAAALPRTLGELQLYRILQKANLLSYFDAFIQQGGDDVQQLCEAGEEEFLEIMALVGMASKPLHVRRLQK      1 - 70
ALRDWVTNPGLFNQPLTSLPVSSIPIYKLPEGSPTWLGISCSSYERSSNAREPHLKIPKCAATTCVQSLG     71 - 140
QGKSDVVGSLALQSVGESRLWQGHHATESEHSLSPADLGSPASPKESSEALDAAAALSVAECVERMAPTL    141 - 210
PKSDLNEVKELLKTNKKLAKMIGHIFEMNDDDPHKEEEIRKYSAIYGRFDSKRKDGKHLTLHELTVNEAA    211 - 280
AQLCVKDNALLTRRDELFALARQISREVTYKYTYRTTKSKCGERDELSPKRIKVEDGFPDFQDSVQTLFQ    281 - 350
QARAKSEELAALSSQQPEKVMAKQMEFLCNQAGYERLQHAERRLSAGLYRQSSEEHSPNGLTSDNSDGQG    351 - 420
ERPLNLRMPNLQNRQPHHFVVDGELSRLYPSEAKSHSSESLGILKDYPHSAFTLEKKVIKTEPEDSR       421 - 487
//

Text Mined References (25)

PMID Year Title
25772364 2015 SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage.
25755297 2015 System-wide Analysis of SUMOylation Dynamics in Response to Replication Stress Reveals Novel Small Ubiquitin-like Modified Target Proteins and Acceptor Lysines Relevant for Genome Stability.
25218447 2014 Uncovering global SUMOylation signaling networks in a site-specific manner.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23935197 2013 Type I IFNs downregulate myeloid cell IFN-? receptor by inducing recruitment of an early growth response 3/NGFI-A binding protein 1 complex that silences ifngr1 transcription.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21836637 2011 The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21399635 2011 Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
21239760 2011 Valproic acid suppresses interleukin-1ß-induced microsomal prostaglandin E2 synthase-1 expression in chondrocytes through upregulation of NAB1.
More...