| Tbio | Cyclin-dependent kinase 5 activator 2 |
Activator of CDK5/TPKII.
The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| glioblastoma | 5792 | 1.6e-11 |
| Astrocytoma, Pilocytic | 3081 | 1.2e-10 |
| atypical teratoid / rhabdoid tumor | 5112 | 8.1e-08 |
| adult high grade glioma | 3801 | 1.2e-05 |
| primitive neuroectodermal tumor | 3035 | 3.1e-04 |
| Down syndrome | 499 | 7.4e-04 |
| medulloblastoma, large-cell | 6241 | 9.5e-04 |
| astrocytic glioma | 2597 | 1.2e-03 |
| ependymoma | 4679 | 2.5e-03 |
| oligodendroglioma | 2850 | 5.0e-03 |
| group 4 medulloblastoma | 1855 | 7.5e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Rectum adenocarcinoma | 8 | 3.036 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -3.000 | 1.2e-05 |
| astrocytic glioma | -2.200 | 1.2e-03 |
| Astrocytoma, Pilocytic | -3.400 | 1.2e-10 |
| atypical teratoid / rhabdoid tumor | -3.100 | 8.1e-08 |
| Down syndrome | -1.300 | 7.4e-04 |
| ependymoma | -2.700 | 2.5e-03 |
| glioblastoma | -2.800 | 1.6e-11 |
| group 4 medulloblastoma | -1.300 | 7.5e-03 |
| medulloblastoma, large-cell | -1.500 | 9.5e-04 |
| oligodendroglioma | -1.700 | 5.0e-03 |
| primitive neuroectodermal tumor | -2.400 | 3.1e-04 |
| Accession | Q13319 Q4ZFW6 CDK5 activator 2 |
| Symbols |
P39 NCK5AI p39nck5ai |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG |
MGTVLSLSPASSAKGRRPGGLPEEKKKAPPAGDEALGGYGAPPVGKGGKGESRLKRPSVLISALTWKRLV 1 - 70 AASAKKKKGSKKVTPKPASTGPDPLVQQRNRENLLRKGRDPPDGGGTAKPLAVPVPTVPAAAATCEPPSG 71 - 140 GSAAAQPPGSGGGKPPPPPPPAPQVAPPVPGGSPRRVIVQASTGELLRCLGDFVCRRCYRLKELSPGELV 141 - 210 GWFRGVDRSLLLQGWQDQAFITPANLVFVYLLCRESLRGDELASAAELQAAFLTCLYLAYSYMGNEISYP 211 - 280 LKPFLVEPDKERFWQRCLRLIQRLSPQMLRLNADPHFFTQVFQDLKNEGEAAASGGGPPSGGAPAASSAA 281 - 350 RDSCAAGTKHWTMNLDR 351 - 367 //
