| Tbio | Early activation antigen CD69 |
Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.
This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011]
This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011]
Comments
Property Summary
| NCBI Gene PubMed Count | 64 |
| Grant Count | 145 |
| R01 Count | 52 |
| Funding | $12,202,068.32 |
| PubMed Score | 1484.95 |
| PubTator Score | 723.86 |
| Disease | log2 FC | p |
|---|---|---|
| hepatocellular carcinoma | -1.100 | 0.009 |
| interstitial lung disease | -2.500 | 0.042 |
| Waldenstrons macroglobulinemia | 2.133 | 0.034 |
| cutaneous lupus erythematosus | 3.700 | 0.000 |
| osteosarcoma | -4.007 | 0.000 |
| posterior fossa group A ependymoma | 1.700 | 0.000 |
| glioblastoma | 1.900 | 0.003 |
| astrocytoma | 1.300 | 0.029 |
| non-small cell lung cancer | -2.752 | 0.000 |
| intraductal papillary-mucinous carcinoma... | -2.400 | 0.003 |
| intraductal papillary-mucinous neoplasm ... | -1.800 | 0.033 |
| lung cancer | -6.100 | 0.000 |
| interstitial cystitis | 1.300 | 0.021 |
| lung adenocarcinoma | -2.074 | 0.000 |
| adult high grade glioma | 2.000 | 0.000 |
| pilocytic astrocytoma | 2.700 | 0.000 |
| primary Sjogren syndrome | 2.600 | 0.000 |
| aldosterone-producing adenoma | -1.057 | 0.041 |
| psoriasis | -1.600 | 0.000 |
| inflammatory breast cancer | -1.100 | 0.000 |
| lung carcinoma | -3.200 | 0.000 |
| invasive ductal carcinoma | 1.600 | 0.032 |
| acute myeloid leukemia | 2.100 | 0.003 |
| ulcerative colitis | 2.700 | 0.000 |
| PMID | Text |
|---|---|
| 26296369 | results demonstrate the functional and mechanistic interplays between CD69 and S100A8/S100A9 in supporting Treg-cell differentiation |
| 24975965 | Elevated expression of CD69 and CD161 on NK cells can be considered as immunological risk markers in RSA and IVF failure. |
| 24752896 | these findings identify CD69 and galectin-1 to be a novel regulatory receptor-ligand pair that modulates Th17 effector cell differentiation and function. |
| 24668348 | Human tumor-infiltrating CD4+CD69+ T cells suppress T cell proliferation via membarene -bound TGF-beta1. |
| 24495362 | Cells expressing HIV-1 Nef from long-term non-progressors and progressive infection patients induce higher surface levels of CD69 and CD25 than cells producing HIV-2 or SIV Nef |
| 24341794 | Cells expressing HIV-1 Nef from long-term non-progressors and progressive infection patients induce higher surface levels of CD69 and CD25 than cells producing HIV-2 or SIV Nef |
| 24044963 | Following coculture with GTKO/CD46 pig mesenchymal stromal cells, it is possible that upregulation of CD69 on human T cells initiates signaling events that would regulate CD4+ and CD8+ T cell activation and differentiation. |
| 23954168 | REVIEW: CD69 exerts a complex immunoregulatory role in humans, and that it could be considered as a target molecule for the therapy of immune-mediated diseases |
| 23758320 | CD69 is induced by integrin alpha4beta1 outside-in signalling and T-cell receptor signalling. |
| 23546309 | This is the first report of the regulation of CD69 expression by LMP-1, and this novel finding may, thus, represent an important link between the EBV oncoprotein LMP-1 and its critical role in the development of EBV-associated diseases. |
| More... |
| PMID | Year | Title |
|---|---|---|
| 26296369 | 2015 | Glycosylation-dependent interaction between CD69 and S100A8/S100A9 complex is required for regulatory T-cell differentiation. |
| 25416956 | 2014 | A proteome-scale map of the human interactome network. |
| 24975965 | 2014 | Increase of CD69, CD161 and CD94 on NK cells in women with recurrent spontaneous abortion and in vitro fertilization failure. |
| 24752896 | 2014 | The leukocyte activation receptor CD69 controls T cell differentiation through its interaction with galectin-1. |
| 24668348 | 2014 | Human hepatocellular carcinoma-infiltrating CD4?CD69?Foxp3? regulatory T cell suppresses T cell response via membrane-bound TGF-?1. |
| 24044963 | Human T cells upregulate CD69 after coculture with xenogeneic genetically-modified pig mesenchymal stromal cells. | |
| 23954168 | 2013 | Is CD69 an effective brake to control inflammatory diseases? |
| 23758320 | 2013 | CD25 and CD69 induction by ?4?1 outside-in signalling requires TCR early signalling complex proteins. |
| 23546309 | 2013 | Epstein-Barr virus latent membrane protein 1 induces CD69 expression through activation of nuclear factor-?B. |
| 23507197 | 2013 | CD69 overexpression by human T-cell leukemia virus type 1 Tax transactivation. |
| More... |
