Tbio | Early activation antigen CD69 |
Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.
This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011]
This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011]
Comments
Disease | Target Count |
---|---|
Arthritis | 248 |
Arthritis, Experimental | 39 |
Diabetes Mellitus, Insulin-Dependent | 77 |
Spontaneous abortion | 108 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Type 1 diabetes mellitus | 104 | 0.0 | 2.0 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Cancer | 2346 | 4.498 | 2.2 |
Hypersensitivity reaction type II disease | 235 | 4.398 | 2.2 |
Human immunodeficiency virus infectious disease | 129 | 4.243 | 2.1 |
Asthma | 349 | 3.869 | 1.9 |
Lymphopenia | 35 | 3.85 | 1.9 |
tuberculosis | 1563 | 3.624 | 1.8 |
Influenza | 142 | 3.608 | 1.8 |
Tetanus | 66 | 3.284 | 1.6 |
Dermatitis | 141 | 3.165 | 1.6 |
Hepatitis | 61 | 3.16 | 1.6 |
Allergic hypersensitivity disease | 123 | 3.012 | 1.5 |
Disease | log2 FC | p |
---|---|---|
hepatocellular carcinoma | -1.100 | 0.009 |
interstitial lung disease | -2.500 | 0.042 |
Waldenstrons macroglobulinemia | 2.133 | 0.034 |
cutaneous lupus erythematosus | 3.700 | 0.000 |
osteosarcoma | -4.007 | 0.000 |
posterior fossa group A ependymoma | 1.700 | 0.000 |
glioblastoma | 1.900 | 0.003 |
astrocytoma | 1.300 | 0.029 |
non-small cell lung cancer | -2.752 | 0.000 |
intraductal papillary-mucinous carcinoma... | -2.400 | 0.003 |
intraductal papillary-mucinous neoplasm ... | -1.800 | 0.033 |
lung cancer | -6.100 | 0.000 |
interstitial cystitis | 1.300 | 0.021 |
lung adenocarcinoma | -2.074 | 0.000 |
adult high grade glioma | 2.000 | 0.000 |
pilocytic astrocytoma | 2.700 | 0.000 |
primary Sjogren syndrome | 2.600 | 0.000 |
aldosterone-producing adenoma | -1.057 | 0.041 |
psoriasis | -1.600 | 0.000 |
inflammatory breast cancer | -1.100 | 0.000 |
lung carcinoma | -3.200 | 0.000 |
invasive ductal carcinoma | 1.600 | 0.032 |
acute myeloid leukemia | 2.100 | 0.003 |
ulcerative colitis | 2.700 | 0.000 |
Accession | Q07108 |
Symbols |
AIM EA1 MLR-3 CLEC2C GP32/28 BL-AC/P26 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG Inparanoid |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA Inparanoid |
Dog | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Pig | OMA EggNOG Inparanoid |
Opossum | OMA EggNOG Inparanoid |
PMID | Text |
---|---|
26296369 | results demonstrate the functional and mechanistic interplays between CD69 and S100A8/S100A9 in supporting Treg-cell differentiation |
24975965 | Elevated expression of CD69 and CD161 on NK cells can be considered as immunological risk markers in RSA and IVF failure. |
24752896 | these findings identify CD69 and galectin-1 to be a novel regulatory receptor-ligand pair that modulates Th17 effector cell differentiation and function. |
24668348 | Human tumor-infiltrating CD4+CD69+ T cells suppress T cell proliferation via membarene -bound TGF-beta1. |
24495362 | Cells expressing HIV-1 Nef from long-term non-progressors and progressive infection patients induce higher surface levels of CD69 and CD25 than cells producing HIV-2 or SIV Nef |
24341794 | Cells expressing HIV-1 Nef from long-term non-progressors and progressive infection patients induce higher surface levels of CD69 and CD25 than cells producing HIV-2 or SIV Nef |
24044963 | Following coculture with GTKO/CD46 pig mesenchymal stromal cells, it is possible that upregulation of CD69 on human T cells initiates signaling events that would regulate CD4+ and CD8+ T cell activation and differentiation. |
23954168 | REVIEW: CD69 exerts a complex immunoregulatory role in humans, and that it could be considered as a target molecule for the therapy of immune-mediated diseases |
23758320 | CD69 is induced by integrin alpha4beta1 outside-in signalling and T-cell receptor signalling. |
23546309 | This is the first report of the regulation of CD69 expression by LMP-1, and this novel finding may, thus, represent an important link between the EBV oncoprotein LMP-1 and its critical role in the development of EBV-associated diseases. |
More... |
PMID | Year | Title |
---|---|---|
26296369 | 2015 | Glycosylation-dependent interaction between CD69 and S100A8/S100A9 complex is required for regulatory T-cell differentiation. |
25416956 | 2014 | A proteome-scale map of the human interactome network. |
24975965 | 2014 | Increase of CD69, CD161 and CD94 on NK cells in women with recurrent spontaneous abortion and in vitro fertilization failure. |
24752896 | 2014 | The leukocyte activation receptor CD69 controls T cell differentiation through its interaction with galectin-1. |
24668348 | 2014 | Human hepatocellular carcinoma-infiltrating CD4?CD69?Foxp3? regulatory T cell suppresses T cell response via membrane-bound TGF-?1. |
24044963 | Human T cells upregulate CD69 after coculture with xenogeneic genetically-modified pig mesenchymal stromal cells. | |
23954168 | 2013 | Is CD69 an effective brake to control inflammatory diseases? |
23758320 | 2013 | CD25 and CD69 induction by ?4?1 outside-in signalling requires TCR early signalling complex proteins. |
23546309 | 2013 | Epstein-Barr virus latent membrane protein 1 induces CD69 expression through activation of nuclear factor-?B. |
23507197 | 2013 | CD69 overexpression by human T-cell leukemia virus type 1 Tax transactivation. |
More... |