Property Summary

NCBI Gene PubMed Count 102
PubMed Score 812.76
PubTator Score 510.38

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
adrenocortical carcinoma 1427 2.03151546440774E-11
non-small cell lung cancer 2798 1.39679013682983E-10
ulcerative colitis 2087 5.83049948004084E-8
pituitary cancer 1972 1.03419100449959E-7
lung adenocarcinoma 2714 7.88356894541378E-7
tuberculosis 1563 2.39252862048332E-6
hepatocellular carcinoma 550 2.77998381529671E-5
medulloblastoma, large-cell 6234 1.36113367876357E-4
osteosarcoma 7933 3.90842852209083E-4
medulloblastoma 1524 8.60861901033908E-4
ovarian cancer 8492 0.00115372556230074
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00175423018637192
pancreatic cancer 2300 0.00179154406475994
pancreatic carcinoma 567 0.00179154406475996
cutaneous lupus erythematosus 1056 0.00185516023960208
interstitial cystitis 2299 0.00376307741809692
chronic rhinosinusitis 512 0.00473442074572885
lung cancer 4473 0.00764445019128592
invasive ductal carcinoma 2950 0.0136710209075041
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.013902680924555
colon cancer 1475 0.018394174431122
gastric carcinoma 832 0.0272531072481332
astrocytic glioma 2241 0.0279883049468269
pancreatic ductal adenocarcinoma liver metastasis 1795 0.0306474133936293
oligodendroglioma 2849 0.0317319977943593


  Differential Expression (25)

Gene RIF (69)

26601115 CREMalpha SNPs rs2295415 and rs1057108 may be novel genetic susceptibility factors for SLE, especially at haplotype level.
25401338 overexpressed in the nuclei of hepatocellular carcinoma cells
24943041 These findings indicated that the polymorphisms of CREM gene were associated with nonobstructive azoospermia in the Chinese population and low CREM expression might be involved in the pathogenesis of spermatogenesis maturation arrest.
24672804 Data suggest ICER/CREM plays seminal role in down-regulation of expression/secretion of insulin by pancreatic beta-cell as an adaptive response to factors that promote diabetes; inappropriate induction of ICER leads to beta-cell dysfunction. [REVIEW]
24667640 CaMK4-dependent activation of AKT/mTOR and CREM-alpha underlies autoimmunity-associated Th17 imbalance.
24297179 CREMalpha orchestrates epigenetic remodeling of the CD8A,B through the recruitment of DNA methyltransferase (DNMT) 3a and histone methyltransferase G9a.
24100545 In Alzheimer's brain, we found an increased cellular expression of CREM in dentate gyrus neurons as compared to normal aging brains.
24047902 transcription factor cAMP-responsive element modulator alpha (CREMalpha), which is expressed at increased levels in T cells from systemic lupus erythematosus patients, contributes to transcriptional silencing of CD8A and CD8B.
23929392 Data suggest that cyclic AMP response element modulator-1 (CREM-1) might play an important role in the regulation of tumor metastasis and invasion and serve as a tumor suppressor in esophageal squamous cell carcinoma (ESCC).
23124208 Increased CREMalpha binding to the Notch-1 promoter resulted in significantly reduced Notch-1 promoter activity and gene transcription.

AA Sequence

LKDICSPKTDY                                                               351 - 361

Text Mined References (109)

PMID Year Title
26601115 2015 Cyclic AMP-Responsive Element Modulator ? Polymorphisms Are Potential Genetic Risks for Systemic Lupus Erythematosus.
25401338 2014 Specific genomic and transcriptomic aberrations in tumors induced by partial hepatectomy of a chronically inflamed murine liver.
24943041 2014 CREM variants rs4934540 and rs2295415 conferred susceptibility to nonobstructive azoospermia risk in the Chinese population.
24672804 2014 Decompensation of ?-cells in diabetes: when pancreatic ?-cells are on ICE(R).
24667640 2014 CaMK4-dependent activation of AKT/mTOR and CREM-? underlies autoimmunity-associated Th17 imbalance.
24297179 2014 cAMP responsive element modulator (CREM) ? mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells.
24100545 2013 Wide distribution of CREM immunoreactivity in adult and fetal human brain, with an increased expression in dentate gyrus neurons of Alzheimer's as compared to normal aging brains.
24047902 2013 cAMP-responsive element modulator ? (CREM?) trans-represses the transmembrane glycoprotein CD8 and contributes to the generation of CD3+CD4-CD8- T cells in health and disease.
23929392 2013 Low expression of cyclic AMP response element modulator-1 can increase the migration and invasion of esophageal squamous cell carcinoma.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.