| Tbio | Pumilio homolog 3 |
Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress (PubMed:21266351). Binds to double-stranded RNA or DNA without sequence specificity (PubMed:25512524). Involved in development of the eye and of primordial germ cells (By similarity).
Comments
| Disease | Target Count | P-value |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 5112 | 1.5e-05 |
| group 3 medulloblastoma | 4104 | 6.7e-05 |
| medulloblastoma, large-cell | 6241 | 3.0e-04 |
| ovarian cancer | 8520 | 8.7e-04 |
| psoriasis | 6694 | 1.3e-03 |
| subependymal giant cell astrocytoma | 2287 | 3.3e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Alzheimer's disease | 658 | 0.0 | 1.1 |
| Brain infarction | 22 | 0.0 | 0.8 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Dental caries | 164 | 6.014 | 3.0 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 1.300 | 1.5e-05 |
| group 3 medulloblastoma | 1.200 | 6.7e-05 |
| medulloblastoma, large-cell | 1.400 | 3.0e-04 |
| ovarian cancer | 1.200 | 8.7e-04 |
| psoriasis | 1.200 | 1.3e-03 |
| subependymal giant cell astrocytoma | 1.153 | 3.3e-02 |
MEVKGKKQFTGKSTKTAQEKNRFHKNSDSGSSKTFPTRKVAKEGGPKVTSRNFEKSITKLGKKGVKQFKN 1 - 70 KQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQ 71 - 140 MWEILRRKDCDKEKRVKLMSDLQKLIQGKIKTIAFAHDSTRVIQCYIQYGNEEQRKQAFEELRDDLVELS 141 - 210 KAKYSRNIVKKFLMYGSKPQIAEIIRSFKGHVRKMLRHAEASAIVEYAYNDKAILEQRNMLTEELYGNTF 211 - 280 QLYKSADHRTLDKVLEVQPEKLELIMDEMKQILTPMAQKEAVIKHSLVHKVFLDFFTYAPPKLRSEMIEA 281 - 350 IREAVVYLAHTHDGARVAMHCLWHGTPKDRKVIVKTMKTYVEKVANGQYSHLVLLAAFDCIDDTKLVKQI 351 - 420 IISEIISSLPSIVNDKYGRKVLLYLLSPRDPAHTVREIIEVLQKGDGNAHSKKDTEVRRRELLESISPAL 421 - 490 LSYLQEHAQEVVLDKSACVLVSDILGSATGDVQPTMNAIASLAATGLHPGGKDGELHIAEHPAGHLVLKW 491 - 560 LIEQDKKMKENGREGCFAKTLVEHVGMKNLKSWASVNRGAIILSSLLQSCDLEVANKVKAALKSLIPTLE 561 - 630 KTKSTSKGIEILLEKLST 631 - 648 //
