| Tchem | Tyrosine-protein phosphatase non-receptor type 12 |
Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172).
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ulcerative colitis | 1819 | 1.9e-07 |
| Chronic Lymphocytic Leukemia | 262 | 3.7e-05 |
| pediatric high grade glioma | 1064 | 5.8e-05 |
| primitive neuroectodermal tumor | 3035 | 6.4e-05 |
| pancreatic cancer | 2398 | 1.3e-04 |
| atypical teratoid / rhabdoid tumor | 5112 | 2.4e-04 |
| ovarian cancer | 8520 | 2.5e-04 |
| psoriasis | 6694 | 3.3e-04 |
| group 4 medulloblastoma | 1855 | 1.1e-03 |
| glioblastoma | 5792 | 2.5e-03 |
| osteosarcoma | 7950 | 2.7e-03 |
| primary Sjogren syndrome | 735 | 3.1e-03 |
| primary pancreatic ductal adenocarcinoma | 1109 | 5.7e-03 |
| oligodendroglioma | 2850 | 8.9e-03 |
| medulloblastoma, large-cell | 6241 | 1.1e-02 |
| lung cancer | 4740 | 1.3e-02 |
| Gaucher disease type 1 | 180 | 1.4e-02 |
| ependymoma | 4679 | 2.2e-02 |
| adrenocortical carcinoma | 1428 | 2.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Pyoderma gangrenosum | 9 | 3.448 | 1.7 |
| Disease | Target Count |
|---|---|
| Carcinoma of colon | 32 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical carcinoma | 1.027 | 2.8e-02 |
| atypical teratoid / rhabdoid tumor | 1.700 | 2.4e-04 |
| Chronic Lymphocytic Leukemia | 2.021 | 3.7e-05 |
| ependymoma | 1.100 | 2.2e-02 |
| Gaucher disease type 1 | -2.100 | 1.4e-02 |
| glioblastoma | 1.700 | 2.5e-03 |
| group 4 medulloblastoma | 1.600 | 1.1e-03 |
| lung cancer | -1.500 | 1.3e-02 |
| medulloblastoma, large-cell | 1.200 | 1.1e-02 |
| oligodendroglioma | 1.300 | 8.9e-03 |
| osteosarcoma | 1.567 | 2.7e-03 |
| ovarian cancer | -1.400 | 2.5e-04 |
| pancreatic cancer | 1.200 | 1.3e-04 |
| pediatric high grade glioma | 1.200 | 5.8e-05 |
| primary pancreatic ductal adenocarcinoma | 1.352 | 5.7e-03 |
| primary Sjogren syndrome | 1.200 | 3.1e-03 |
| primitive neuroectodermal tumor | 1.500 | 6.4e-05 |
| psoriasis | -1.200 | 3.3e-04 |
| ulcerative colitis | 1.100 | 1.9e-07 |
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPF 1 - 70 DHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGR 71 - 140 KKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSIL 141 - 210 DMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTK 211 - 280 EQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVNEINTENMVSSIEPEKQDSPPPKPPRTRSCLVEGDAK 281 - 350 EEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSEQHSADLNRNYSKSTELPGKNE 351 - 420 STIEQIDKKLERNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASPCIADKISKPQELSSDLNVGDT 421 - 490 SQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHGPENAIPIPDLSEGNSSDINY 491 - 560 QTRKTVSLTPSPTTQVETPDLVDHDNTSPLFRTPLSFTNPLHSDDSDSDERNSDGAVTQNKTNISTASAT 561 - 630 VSAATSTESISTRKVLPMSIARHNIAGTTHSGAEKDVDVSEDSPPPLPERTPESFVLASEHNTPVRSEWS 631 - 700 ELQSQERSEQKKSEGLITSENEKCDHPAGGIHYEMCIECPPTFSDKREQISENPTEATDIGFGNRCGKPK 701 - 770 GPRDPPSEWT 771 - 780 //
