Tbio PRSS56 Serine protease 56

Protein Summary

Description

Serine protease required during eye development. This gene encodes a protein that contains a peptidase S1 domain and possesses trypsin-like serine protease activity. The encoded protein may play a role in eye development, and mutations in this gene are a cause of autosomal recessive posterior microphthalmos. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• P0CW18

Gene Name

• PRSS56

Ensembl ID

• ENST00000617714
• ENSP00000479745
• ENSG00000237412

Symbol

• MCOP6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.62
protein domain	0.58
cellular component	0.55
cell type or tissue	0.46
cell line	0.44

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Serine Protease 56

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Serine Protease 56

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.72   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 51   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.72   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0