| Tbio | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform |
B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).
Comments
| Disease | Target Count | P-value |
|---|---|---|
| glioblastoma | 5792 | 3.5e-11 |
| Astrocytoma, Pilocytic | 3081 | 1.2e-09 |
| adult high grade glioma | 3801 | 2.2e-08 |
| atypical teratoid / rhabdoid tumor | 5112 | 4.7e-08 |
| medulloblastoma, large-cell | 6241 | 1.7e-06 |
| primitive neuroectodermal tumor | 3035 | 1.2e-04 |
| osteosarcoma | 7950 | 1.3e-04 |
| group 4 medulloblastoma | 1855 | 3.5e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 1.2e-03 |
| astrocytic glioma | 2597 | 3.1e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 3.9e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 7.8e-03 |
| subependymal giant cell astrocytoma | 2287 | 1.8e-02 |
| ependymoma | 4679 | 2.1e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -2.500 | 2.2e-08 |
| astrocytic glioma | -1.200 | 3.1e-03 |
| Astrocytoma, Pilocytic | -1.900 | 1.2e-09 |
| atypical teratoid / rhabdoid tumor | -2.500 | 4.7e-08 |
| ependymoma | -1.400 | 2.1e-02 |
| glioblastoma | -2.200 | 3.5e-11 |
| group 4 medulloblastoma | -1.200 | 3.5e-04 |
| intraductal papillary-mucinous adenoma (... | -1.400 | 1.2e-03 |
| intraductal papillary-mucinous carcinoma... | -1.400 | 3.9e-03 |
| intraductal papillary-mucinous neoplasm ... | -1.700 | 7.8e-03 |
| medulloblastoma, large-cell | -2.500 | 1.7e-06 |
| osteosarcoma | -1.691 | 1.3e-04 |
| primitive neuroectodermal tumor | -1.600 | 1.2e-04 |
| subependymal giant cell astrocytoma | -2.046 | 1.8e-02 |
MAGAGGGGCPAGGNDFQWCFSQVKGAIDEDVAEADIISTVEFNYSGDLLATGDKGGRVVIFQREQENKSR 1 - 70 PHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAHFLLSTNDKTIKLWKISERDKRAEGY 71 - 140 NLKDEDGRLRDPFRITALRVPILKPMDLMVEASPRRIFANAHTYHINSISVNSDHETYLSADDLRINLWH 141 - 210 LEITDRSFNIVDIKPANMEELTEVITAAEFHPHQCNVFVYSSSKGTIRLCDMRSSALCDRHSKFFEEPED 211 - 280 PSSRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKVWDLNMESRPVETHQVHEYLRSKLCSLYENDCIFD 281 - 350 KFECCWNGSDSAIMTGSYNNFFRMFDRDTRRDVTLEASRESSKPRASLKPRKVCTGGKRRKDEISVDSLD 351 - 420 FNKKILHTAWHPVDNVIAVAATNNLYIFQDKIN 421 - 453 //
