1. Home
  2. Targets
  3. isomerase
  4. Peptidyl-prolyl cis-trans isomerase-like 6

Tdark Peptidyl-prolyl cis-trans isomerase-like 6

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

 Comments

Property Summary

NCBI Gene PubMed Count 5
PubMed Score 0.20
PubTator Score 3.93

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (1)

Disease Target Count P-value
lung adenocarcinoma 2714 1.1e-10
posterior fossa group B ependymoma 1530 7.3e-10

Expression

  Differential Expression (2)

Disease log2 FC p
posterior fossa group B ependymoma 2.100 7.3e-10
lung adenocarcinoma -1.800 1.1e-10

Synonym

Accession Q8IXY8 A9NIU0 A9NIU9 E7EX15 PPIase
Symbols PPIase
RSPH12
bA425D10.6
dJ919F19.1

Gene

PPIL6

PANTHER Protein Class (1)

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (6)

 GO Function (1)

 GO Process (1)

 Compartment GO Term (3)

 GWAS Trait (1)

 HCA RNA Cell Line (56)

See all...

AA Sequence 

MARPQPCGPPHARCGSPSLPERPLQVKVVGLFSCPNFQIAKSAAENLKNNHPSKFEDPILVPLQEFAWHQ      1 - 70
YLQEKKRELKNETWEYSSSVISFVNGQFLGDALDLQKWAHEVWDIVDIKPSALYDALTEDFSAKFLRDTK     71 - 140
HDFVFLDICIDSSPIGRLIFELYCDVCPKTCKNFQVLCTGKAGFSQRGIRLHYKNSIFHRIVQNGWIQGG    141 - 210
DIVYGKGDNGESIYGPTFEDENFSVPHNKRGVLGMANKGRHSNGSQFYITLQATPYLDRKFVAFGQLIEG    211 - 280
TEVLKQLELVPTQNERPIHMCRITDSGDPYA                                           281 - 311
//

Text Mined References (5)

PMID Year Title
18391951 2008 Many sequence variants affecting diversity of adult human height.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14574404 2003 The DNA sequence and analysis of human chromosome 6.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.