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  6. DNA polymerase alpha subunit B

Tbio DNA polymerase alpha subunit B

May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery.

 Comments

Property Summary

NCBI Gene PubMed Count 22
PubMed Score 3.76
PubTator Score 2.61

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count P-value
non-small cell lung cancer 2799 1.8e-17
osteosarcoma 7766 2.0e-06
malignant mesothelioma 3135 3.2e-06
medulloblastoma, large-cell 6086 1.2e-04
Disease Target Count Z-score Confidence
Ovarian serous carcinoma 5 3.325 1.7

Expression

  Differential Expression (4)

Disease log2 FC p
malignant mesothelioma 1.400 3.2e-06
medulloblastoma, large-cell 1.200 1.2e-04
non-small cell lung cancer 1.083 1.8e-17
osteosarcoma -1.329 2.0e-06

Synonym

Accession Q14181 B4DNB4 Q9BPV3
Symbols

Gene

POLA2

PANTHER Protein Class (3)

PDB

5EXR   4Y97   2KEB   4E2I  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (8)

 GO Function (3)

 GO Component (3)

 GO Process (5)

 Compartment GO Term (41)

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 IMPC Phenotype (6)

 MGI Phenotype (2)

 HCA RNA Cell Line (56)

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Pathway (32)

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Protein-protein Interaction (1)

PRIM2  

Gene RIF (6)

AA Sequence 

MSASAQQLAEELQIFGLDCEEALIEKLVELCVQYGQNEEGMVGELIAFCTSTHKVGLTSEILNSFEHEFL      1 - 70
SKRLSKARHSTCKDSGHAGARDIVSIQELIEVEEEEEILLNSYTTPSKGSQKRAISTPETPLTKRSVSTR     71 - 140
SPHQLLSPSSFSPSATPSQKYNSRSNRGEVVTSFGLAQGVSWSGRGGAGNISLKVLGCPEALTGSYKSMF    141 - 210
QKLPDIREVLTCKIEELGSELKEHYKIEAFTPLLAPAQEPVTLLGQIGCDSNGKLNNKSVILEGDREHSS    211 - 280
GAQIPVDLSELKEYSLFPGQVVIMEGINTTGRKLVATKLYEGVPLPFYQPTEEDADFEQSMVLVACGPYT    281 - 350
TSDSITYDPLLDLIAVINHDRPDVCILFGPFLDAKHEQVENCLLTSPFEDIFKQCLRTIIEGTRSSGSHL    351 - 420
VFVPSLRDVHHEPVYPQPPFSYSDLSREDKKQVQFVSEPCSLSINGVIFGLTSTDLLFHLGAEEISSSSG    421 - 490
TSDRFSRILKHILTQRSYYPLYPPQEDMAIDYESFYVYAQLPVTPDVLIIPSELRYFVKDVLGCVCVNPG    491 - 560
RLTKGQVGGTFARLYLRRPAADGAERQSPCIAVQVVRI                                    561 - 598
//

Text Mined References (30)

PMID Year Title