Tbio PLXND1 Plexin-D1

Protein Summary

Description

Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in response to SEMA3E.

Uniprot Accession IDs

• Q9Y4D7
• A7E2C6
• C9JPZ6
• Q6PJS9
• Q8IZJ2
• Q9BTQ2

Gene Name

• PLXND1

Ensembl ID

• ENST00000324093
• ENSP00000317128
• ENSG00000004399

Symbol

• KIAA0620
• PLEXD1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
transcription factor perturbation	0.94
disease perturbation	0.83
PubMedID	0.8
gene perturbation	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.77   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 233   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.77   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0