| Tchem | Programmed cell death protein 4 |
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Comments
Property Summary
| Ligand Count | 3 |
| NCBI Gene PubMed Count | 200 |
| PubMed Score | 320.95 |
| PubTator Score | 271.04 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Cell Transformation, Neoplastic | 97 | 0.0 | 0.0 |
| Lung Neoplasms | 232 | 0.0 | 0.0 |
| Neoplasm Invasiveness | 161 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Prevention of Kidney Transplant Rejection | 17 |
| Pulmonary lymphangioleiomyomatosis | 5 |
| Renal Cell Carcinoma | 214 |
| Disease | Target Count | P-value |
|---|---|---|
| tuberculosis | 2010 | 1.6e-08 |
| psoriasis | 6694 | 4.0e-08 |
| ulcerative colitis | 1819 | 2.5e-07 |
| colon cancer | 1478 | 3.1e-06 |
| ovarian cancer | 8520 | 9.1e-06 |
| osteosarcoma | 7950 | 4.3e-05 |
| pancreatic cancer | 2398 | 4.4e-05 |
| ependymoma | 4679 | 3.2e-04 |
| lung adenocarcinoma | 2716 | 1.1e-03 |
| adrenocortical carcinoma | 1428 | 1.3e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 4.4e-03 |
| atypical teratoid / rhabdoid tumor | 5112 | 6.7e-03 |
| primary pancreatic ductal adenocarcinoma | 1109 | 1.3e-02 |
| sonic hedgehog group medulloblastoma | 467 | 2.0e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 2.1e-02 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 3.6e-02 |
| subependymal giant cell astrocytoma | 2287 | 3.7e-02 |
| esophageal adenocarcinoma | 737 | 4.5e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical carcinoma | 1.163 | 1.3e-03 |
| atypical teratoid / rhabdoid tumor | 1.200 | 6.7e-03 |
| colon cancer | -1.500 | 3.1e-06 |
| ependymoma | 1.100 | 3.2e-04 |
| esophageal adenocarcinoma | -1.400 | 4.5e-02 |
| intraductal papillary-mucinous adenoma (... | -1.100 | 3.6e-02 |
| intraductal papillary-mucinous carcinoma... | -1.900 | 4.4e-03 |
| intraductal papillary-mucinous neoplasm ... | -1.800 | 2.1e-02 |
| lung adenocarcinoma | 1.138 | 1.1e-03 |
| osteosarcoma | -2.368 | 4.3e-05 |
| ovarian cancer | -1.700 | 9.1e-06 |
| pancreatic cancer | -1.300 | 4.4e-05 |
| primary pancreatic ductal adenocarcinoma | -1.518 | 1.3e-02 |
| psoriasis | -1.500 | 4.0e-08 |
| sonic hedgehog group medulloblastoma | 1.100 | 2.0e-02 |
| subependymal giant cell astrocytoma | 1.226 | 3.7e-02 |
| tuberculosis | -1.600 | 1.6e-08 |
| ulcerative colitis | -2.300 | 2.5e-07 |
MDVENEQILNVNPADPDNLSDSLFSGDEENAGTEEIKNEINGNWISASSINEARINAKAKRRLRKNSSRD 1 - 70 SGRGDSVSDSGSDALRSGLTVPTSPKGRLLDRRSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKD 71 - 140 PNYDDDQENCVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALE 141 - 210 GKASHREMTSKLLSDLCGTVMSTTDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYID 211 - 280 SYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVKEIDMLLKEYLLSGDISEAEHC 281 - 350 LKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDVP 351 - 420 HSYSVLERFVEECFQAGIISKQLRDLCPSRGRKRFVSEGDGGRLKPESY 421 - 469 //
