Property Summary

NCBI Gene PubMed Count 19
PubMed Score 2.97
PubTator Score 10.03

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (3)

Disease log2 FC p
primary Sjogren syndrome -1.500 0.003
ductal carcinoma in situ 2.000 0.002
invasive ductal carcinoma 2.100 0.004

Gene RIF (9)

PMID Text
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20179103 Pin1 regulates BPGAP1 function in Rho and Erk signalling, with active Mek2 serving as a novel regulatory scaffold that promotes crosstalk between RhoGAP, Pin1 and Erk in the regulation of cell migration.
19913121 Observational study of gene-disease association. (HuGE Navigator)
15944398 findings reveal a concomitant activation of endocytosis and ERK signaling by BPGAP1 via the coupling of its proline-rich region, which targets EEN and its functional GAP domain
15506981 BPGAP1 is a novel RhoGAP that co-ordinately regulates pseudopodia and cell migration through the interplay of its BNIP-2 and Cdc42GAP homology domains.
15225876 ARHGAP8 expression was up-regulated in the majority of primary colorectal tumors analyzed in this work.
15064355 RhoGAP functionally interacts with cortactin and represents a novel determinant in the regulation of cell dynamics.
12944407 BPGAP1 has a role in regulating cell dynamics with BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of BPGAP1
12559566 This paper compares the protein sequences and genomic structures of human and mouse ARHGAP8.

AA Sequence

MAGQDPALSTSHPFYDVARHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYLKYTLDQYVENDY      1 - 70
TIVYFHYGLNSRNKPSLGWLQSAYKEFDRKDGDLTMWPRLVSNSKLKRSSHLSLPKYWDYRYKKNLKALY     71 - 140
VVHPTSFIKVLWNILKPLISHKFGKKVIYFNYLSELHEHLKYDQLVIPPEVLRYDEKLQSLHEGRTPPPT    141 - 210
KTPPPRPPLPTQQFGVSLQYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQ    211 - 280
GKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLR    281 - 350
YLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGE    351 - 420
HGLAPWEQGSRAAPLQEAVPRTQATGLTKPTLPPSPLMAARRRL                              421 - 464
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Text Mined References (20)

PMID Year Title
24882193 2014 Bipolar disorder with comorbid binge eating history: a genome-wide association study implicates APOB.
22863734 2012 Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.
22554406 2012 Family-based genome-wide association study of frontal ? oscillations identifies potassium channel gene KCNJ6.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20179103 2010 Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migration.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
18217980 Microarray analysis of normal cervix, carcinoma in situ, and invasive cervical cancer: identification of candidate genes in pathogenesis of invasion in cervical cancer.
16555160 2006 [Refined deletion mapping of loss of heterozygosity on 22q13 in sporadic colorectal carcinoma].
15955831 2005 Transcriptional profiling of human hematopoiesis during in vitro lineage-specific differentiation.
15944398 2005 Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain.
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