Property Summary

NCBI Gene PubMed Count 56
PubMed Score 119.72
PubTator Score 99.06

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count P-value
psoriasis 6685 2.16641468709149E-37
juvenile dermatomyositis 1189 1.28054827320057E-9
interstitial cystitis 2299 1.79381901896992E-6
posterior fossa group A ependymoma 1511 8.14754972271019E-6
lung cancer 4473 2.28610990259723E-5
pilocytic astrocytoma 3086 2.52543467128695E-5
cutaneous lupus erythematosus 1056 3.48177517965497E-5
medulloblastoma, large-cell 6234 2.33773212374306E-4
nasopharyngeal carcinoma 1056 0.00125705487231864
ovarian cancer 8492 0.00182621472391042
adrenocortical carcinoma 1427 0.00318986680287093
adult high grade glioma 2148 0.00350887505700175
glioblastoma 5572 0.0042075150412687
head and neck cancer and chronic obstructive pulmonary disease 237 0.00582372970659856
Breast cancer 3099 0.00920815627682922
aldosterone-producing adenoma 664 0.0107924791623607
tuberculosis and treatment for 6 months 686 0.0115587610209958
atypical teratoid / rhabdoid tumor 4369 0.01365579258839
adrenocortical adenoma 134 0.0222812953346285
colon cancer 1475 0.0260146276270096
invasive ductal carcinoma 2950 0.0355973512795466
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0405868728536409
sarcoidosis 368 0.0415230018419688
ulcerative colitis 2087 0.0421381306638259
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0457498763892548
Disease Target Count Z-score Confidence
Tenosynovitis 15 4.257 2.1
Arthritis 248 3.533 1.8
Synovitis 72 3.331 1.7

Expression

Synonym

Accession P80075 A0AV77 P78388
Symbols HC14
MCP2
MCP-2
SCYA8
SCYA10

Gene

PDB

1ESR  

  Ortholog (7)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA Inparanoid
Rat OMA Inparanoid
Dog OMA Inparanoid
Cow OMA Inparanoid
Pig EggNOG Inparanoid

Gene RIF (41)

PMID Text
26320180 Dermal fibroblast CCL8 promotes melanoma metastasis.
26116899 HIV-1 Vpr upregulates the gene expression of CCL8 in human monocyte-derived dendritic cells
25253336 Authors show that the previously observed downregulation of hsa-miR-92a and upregulation of CCL8 during human cytomegalovirus latent infection of myeloid cells are intimately linked via the latency-associated expression of cytomegalovirus UL111A.
24742347 HIV-1 Vpr upregulates the gene expression of CCL8 in human monocyte-derived dendritic cells
24196705 HIV-1 Vpr upregulates the gene expression of CCL8 in human monocyte-derived dendritic cells
23535064 HIV-1 Vpr upregulates the gene expression of CCL8 in human monocyte-derived dendritic cells
23418602 Results indicate that the induction of MCP-2/CCL8 by mycobacteria is dependent on the activation of TLR2/PI3K/Akt signaling pathway.
23383108 HIV-1 Vpr upregulates the gene expression of CCL8 in human monocyte-derived dendritic cells
22987449 JAK2 and STAT3 activation is not essential for CCL3, CCL5 or CCL8 induced chemotaxis.
21945122 Macrophage Colony Stimulating Factor and Monocyte Chemoattractant Protein are elevated in sera of intrinsic asthmatics compared to normal controls.
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AA Sequence

MKVSAALLCLLLMAATFSPQGLAQPDSVSIPITCCFNVINRKIPIQRLESYTRITNIQCPKEAVIFKTKR      1 - 70
GKEVCADPKERWVRDSMKHLDQIFQNLKP                                              71 - 99
//

Text Mined References (56)

PMID Year Title
26320180 2015 The importance of microenvironment: the role of CCL8 in metastasis formation of melanoma.
25253336 2014 Latency-associated viral interleukin-10 (IL-10) encoded by human cytomegalovirus modulates cellular IL-10 and CCL8 Secretion during latent infection through changes in the cellular microRNA hsa-miR-92a.
23418602 2013 Induction of CCL8/MCP-2 by mycobacteria through the activation of TLR2/PI3K/Akt signaling pathway.
22987449 2013 Janus kinase 2 and signal transducer and activator of transcription 3 activation is not essential for CCL3-, CCL5- or CCL8-induced chemotaxis.
22412388 2012 A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
21945122 2011 Macrophage colony stimulating factor and monocyte chemoattractant protein 2 are elevated in intrinsic asthmatics.
21514686 2011 Polymorphisms of key chemokine genes and survival of non-small cell lung cancer in Chinese.
21220697 2011 Chemokine transcripts as targets of the RNA-binding protein HuR in human airway epithelium.
20503287 2010 Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.
20438785 2010 Polymorphisms in innate immunity genes and risk of childhood leukemia.
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