| Tchem | Phylloquinone omega-hydroxylase CYP4F2 |
Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:19297519, PubMed:24138531). Also shows arachidonic acid omega-hydroxylase activity in kidney, by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), possibly influencing blood pressure control (PubMed:10660572, PubMed:17341693, PubMed:18574070). Also acts as a leukotriene-B(4) omega-hydroxylase by mediating conversion of leukotriene-B(4) (LTB4) to its omega-hydroxylated metabolite 20-hydroxyleukotriene-B(4) (20-OH LTB4) (PubMed:8026587, PubMed:9799565).
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away. [provided by RefSeq, Jul 2008]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| Ligand Count | 1 |
| NCBI Gene PubMed Count | 120 |
| PubMed Score | 145.54 |
| PubTator Score | 169.48 |
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 3.9e-08 |
| osteosarcoma | 7950 | 1.1e-05 |
| lung cancer | 4740 | 3.8e-05 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 2.5e-02 |
| active Crohn's disease | 922 | 2.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Inflammatory bowel disease 6 | 6 | 3.892 | 1.9 |
| Atrial Fibrillation | 124 | 3.591 | 1.8 |
| Hypertension | 396 | 3.289 | 1.6 |
| Cerebrovascular disease | 238 | 3.113 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| active Crohn's disease | -2.216 | 2.8e-02 |
| lung cancer | 2.300 | 3.8e-05 |
| osteosarcoma | -2.217 | 1.1e-05 |
| ovarian cancer | 1.100 | 3.9e-08 |
| pancreatic ductal adenocarcinoma liver m... | -1.785 | 2.5e-02 |
MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPT 1 - 70 EEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSA 71 - 140 GDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSF 141 - 210 DSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPS 211 - 280 QGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEY 281 - 350 QERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIIC 351 - 420 LISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFR 421 - 490 VLPDHTEPRRKPELVLRAEGGLWLRVEPLS 491 - 520 //
